120万一支的抗癌神药，你认识吗？
<img src="https://mmbiz.qpic.cn/mmbiz_png/7aOnNMtZQQskXk3wQnpTWoXJlNRLLNMFMibmS0V3eaeTsc3UsSiavfxIgyzoArqgBQciatLQEIeFNkIvjxuNZOdibg/640?wx_fmt=png&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;"><p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">120万</span></strong><span style="color: black;">一支的</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"> <strong style="color: blue;">抗癌神药</strong></span>，</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">你<span style="color: black;">认识</span>吗？</span></p><img src="https://mmbiz.qpic.cn/mmbiz_svg/4QtDCkraacPEcZDepeADvS0DWKseK7n3hiboJH1COhLKAe8GICjwDr6NbMtJlaiaj6ticUzicqDHts2OYDCbuSmZjVIzGV10uicpG/640?wx_fmt=svg&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;">
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">今天有一位<span style="color: black;">病人</span>在门诊中问我：“<span style="color: black;">大夫</span>，我听说<span style="color: black;">此刻</span>有一种价格高达120万一支的抗癌神药，<span style="color: black;">据述</span>非常神奇，只需<span style="color: black;">运用</span>一次就能完全清除肿瘤，您认为这种神药适用于治疗我的肺癌吗？” </p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">下面我给<span style="color: black;">大众</span>科普一下被喻为“抗癌神药”的CAR-T细胞疗法吧。</p><img src="https://mmbiz.qpic.cn/mmbiz_png/7aOnNMtZQQskXk3wQnpTWoXJlNRLLNMFliay03Qo7upRJKBN9zHxY1DzhS1ZVAX9TeRkKDzMGckzB2MMiaXGAuLA/640?wx_fmt=png&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;"><img src="https://mmbiz.qpic.cn/mmbiz_png/7aOnNMtZQQskXk3wQnpTWoXJlNRLLNMFAnCvaC98Ww09BdoTtx0qoT1wMvoFQibMvs5CHuJy9FzeZQ5O691R4jw/640?wx_fmt=png&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;">
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">什么是CAR-T疗法？</strong></p><img src="https://mmbiz.qpic.cn/mmbiz_jpg/7aOnNMtZQQskXk3wQnpTWoXJlNRLLNMFN2dPXmLOeYMJ9ICEIoUzMlPwJ301R3zNULRt8icmNlG3Boyk4fUztDg/640?wx_fmt=jpeg&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;">
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">CAR-T疗法是嵌合抗原受体T细胞免疫疗法<span style="color: black;">（Chimeric Antigen Receptor T-Cell Immunotherapy）</span>的简<span style="color: black;">叫作</span>。这种新型细胞免疫治疗，其基本原理是利用<span style="color: black;">病人</span><span style="color: black;">自己</span>的免疫细胞来清除<span style="color: black;">身体</span>的癌细胞。</p><img src="https://mmbiz.qpic.cn/mmbiz_png/7aOnNMtZQQskXk3wQnpTWoXJlNRLLNMFAnCvaC98Ww09BdoTtx0qoT1wMvoFQibMvs5CHuJy9FzeZQ5O691R4jw/640?wx_fmt=png&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;">
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">CAR-T疗法</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"> 用的抗癌神药是药吗？</strong></p><img src="https://mmbiz.qpic.cn/mmbiz_png/7aOnNMtZQQskXk3wQnpTWoXJlNRLLNMFYJtv9a9sH2KLrABfNmhOITjYibLaFK8WlheeefF5OianbhLmeInSiaHiaQ/640?wx_fmt=png&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;">
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">CAR-T疗法所用的<span style="color: black;">药品</span>并非常规<span style="color: black;">道理</span>上的化学<span style="color: black;">药品</span>，而是把<span style="color: black;">病人</span>的免疫T细胞采集出来，经过体外加工改造、扩增形成的数量巨大的细胞群，是一种私人定制的“<span style="color: black;">药物</span>”。</p><img src="https://mmbiz.qpic.cn/mmbiz_png/7aOnNMtZQQskXk3wQnpTWoXJlNRLLNMFAnCvaC98Ww09BdoTtx0qoT1wMvoFQibMvs5CHuJy9FzeZQ5O691R4jw/640?wx_fmt=png&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;">
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">CAR-T疗法</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"> 适用于什么样的<span style="color: black;">病人</span>呢？</strong></p><img src="https://mmbiz.qpic.cn/mmbiz_png/7aOnNMtZQQskXk3wQnpTWoXJlNRLLNMF86ypRL3U4f3c8ibOOZ64eLQrxzAzEDRgCwk8pwM8B5r6MLtMFsOkGsQ/640?wx_fmt=png&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;">
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">CAR-T疗法适用人群<span style="color: black;">特别有</span>限，<span style="color: black;">日前</span>仅适用于系统性治疗后复发或难治性某些类型的淋巴瘤<span style="color: black;">病人</span>，<span style="color: black;">况且</span>这些<span style="color: black;">病人</span><span style="color: black;">身体</span>的癌细胞表面<span style="color: black;">必要</span>有CD19表达的临床特征。CAR-T疗法并不适用于胃癌，肺癌，肝癌等<span style="color: black;">平常</span>癌症。</p><img src="https://mmbiz.qpic.cn/mmbiz_png/7aOnNMtZQQskXk3wQnpTWoXJlNRLLNMFAnCvaC98Ww09BdoTtx0qoT1wMvoFQibMvs5CHuJy9FzeZQ5O691R4jw/640?wx_fmt=png&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;">
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">CAR-T疗法</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"> 价格<span style="color: black;">为何</span>如此昂贵呢？</strong></p><img src="https://mmbiz.qpic.cn/mmbiz_png/7aOnNMtZQQskXk3wQnpTWoXJlNRLLNMF1Zwhs9iaDDtGibkibvy3s8vnDbn80tGWesR2Z3dem3QM0wdqXKSYf9Edg/640?wx_fmt=png&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;">
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">首要</span>，CAR-T疗法用的“神药”是一种“私人定制”而非批量生产的<span style="color: black;">制品</span>，成本很高；其次，生产过程<span style="color: black;">繁杂</span>，<span style="color: black;">必须</span>先采集<span style="color: black;">病人</span><span style="color: black;">身体</span>的免疫T细胞，<span style="color: black;">而后</span>对其进行体外改造、加工、扩增，时间成本高；第三，这种活的细胞，在人体外进行扩增达到<span style="color: black;">必定</span>的数量，在生产技术及生产设备上投入很大；第四，CAR-T输入<span style="color: black;">病人</span><span style="color: black;">身体</span>后，可能激发严重的细胞因子风暴即细胞因子释放<span style="color: black;">综合症</span>，<span style="color: black;">必须</span>密切观察、<span style="color: black;">即时</span>处理，对医疗<span style="color: black;">公司</span>及医务人员有<span style="color: black;">必定</span><span style="color: black;">需求</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">综上所述，CAR-T疗法价格就<span style="color: black;">不方便</span>宜了。</p><img src="https://mmbiz.qpic.cn/mmbiz_png/7aOnNMtZQQskXk3wQnpTWoXJlNRLLNMFAnCvaC98Ww09BdoTtx0qoT1wMvoFQibMvs5CHuJy9FzeZQ5O691R4jw/640?wx_fmt=png&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;">
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">CAR-T疗法的疗程要多久？</strong></p><img src="https://mmbiz.qpic.cn/mmbiz_png/7aOnNMtZQQskXk3wQnpTWoXJlNRLLNMFeH6GuH1PlChNAsaotd49eWj7gOZWf4vCQWic7TRwfr3SIiaeBia3ibAzAA/640?wx_fmt=png&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;">
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">CAR-T细胞能特异地识别和杀灭人<span style="color: black;">身体</span>表达CD19的癌细胞，经扩增达到<span style="color: black;">必定</span>数量后，注入<span style="color: black;">病人</span><span style="color: black;">身体</span>后，去消灭<span style="color: black;">乃至</span>清除<span style="color: black;">身体</span>的癌细胞，<span style="color: black;">拥有</span><span style="color: black;">长时间</span>治疗效果。<span style="color: black;">通常</span><span style="color: black;">来讲</span>，只需治疗1次。</p><img src="https://mmbiz.qpic.cn/mmbiz_png/7aOnNMtZQQskXk3wQnpTWoXJlNRLLNMFAnCvaC98Ww09BdoTtx0qoT1wMvoFQibMvs5CHuJy9FzeZQ5O691R4jw/640?wx_fmt=png&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;">
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">CAR-T疗法</strong><strong style="color: blue;">副<span style="color: black;">功效</span>大吗？</strong></p><img src="https://mmbiz.qpic.cn/mmbiz_png/7aOnNMtZQQskXk3wQnpTWoXJlNRLLNMFPSWwbjzkMTosToLCaBzz6wtK85bkjlicBALmZGuTkVGVSOADdWKjUMQ/640?wx_fmt=png&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;">
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">价格这么高的CAR-T疗法<span style="color: black;">亦</span>是不完美的，<span style="color: black;">病人</span>接受CAR-T疗法最大的副<span style="color: black;">功效</span><span style="color: black;">便是</span>细胞因子释放<span style="color: black;">综合症</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">数目巨大的CAR-T细胞在快速有效杀死癌细胞时释放超<span style="color: black;">海量</span>的细胞因子，从而激活更多的免疫细胞来<span style="color: black;">一块</span>对抗这些癌细胞，<span style="color: black;">导致</span>惊人的免疫反应即细胞因子风暴。临床表现为<span style="color: black;">病人</span>高热不退，<span style="color: black;">倘若</span>不密切监测、不<span style="color: black;">即时</span><span style="color: black;">干涉</span>，可能会有生命危险。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">因此</span>说CAR-T疗法<span style="color: black;">必定</span>要在有经验的医疗<span style="color: black;">公司</span>进行，治疗时要严密监护<span style="color: black;">病人</span>。</p><img src="https://mmbiz.qpic.cn/mmbiz_png/7aOnNMtZQQskXk3wQnpTWoXJlNRLLNMFAnCvaC98Ww09BdoTtx0qoT1wMvoFQibMvs5CHuJy9FzeZQ5O691R4jw/640?wx_fmt=png&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;">
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">CAR-T疗法</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"> 治疗时要<span style="color: black;">重视</span>什么？</strong></p><img src="https://mmbiz.qpic.cn/mmbiz_png/7aOnNMtZQQskXk3wQnpTWoXJlNRLLNMFzuXgHediaaYGgbkJjCMSGSVKd1T6RXcqDa0EQHh1via2Lma0YdHrWImg/640?wx_fmt=png&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;"><img src="https://mmbiz.qpic.cn/mmbiz_png/7aOnNMtZQQskXk3wQnpTWoXJlNRLLNMFByOYTJop5WmoqfSOT5go2Y8Q339tTScUwzC0Ribia17fZa1ics5Cwqia9A/640?wx_fmt=png&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;"><img src="https://mmbiz.qpic.cn/mmbiz_png/7aOnNMtZQQskXk3wQnpTWoXJlNRLLNMFMaakMVLR9SBI4Vtd7AZUoaD3sM16AokLXxef8Zgu6lULZQB2oOekCQ/640?wx_fmt=png&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;">
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">CAR-T疗法仅供<span style="color: black;">病人</span>自体<span style="color: black;">运用</span>，<span style="color: black;">因此呢</span>注射前务必认真核对<span style="color: black;">病人</span>身份信息；其次输注中及输注后可能<span style="color: black;">显现</span>严重炎性反应，故输注前<span style="color: black;">保证</span>备有完善的监测系统及急救设备、<span style="color: black;">药物</span>等。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">好了，科普了这么多CAR-T疗法的知识点，这个门诊肺癌<span style="color: black;">病人</span>的问题自然就有了答案：依据<span style="color: black;">日前</span>的<span style="color: black;">科研</span>结果，<strong style="color: blue;">CAR-T疗法仅限于系统性治疗后复发或难治的某些淋巴瘤<span style="color: black;">病人</span></strong>，<strong style="color: blue;">并不适用于肺癌<span style="color: black;">病人</span>。</strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">文 / 肿瘤内科 刘宁红</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">作者介绍</strong></p><img src="https://mmbiz.qpic.cn/mmbiz_jpg/7aOnNMtZQQskXk3wQnpTWoXJlNRLLNMFDMUiczuTicfCZj6A6aeYelEeficrzQgcveylCwXQmBCIvCicREx2931KBw/640?wx_fmt=jpeg&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;">
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"> 刘宁红</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">专家</span>医师</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">北京老年医院 肿瘤内科<span style="color: black;">专家</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">北京抗癌协会早癌筛查青委会委员</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">北京医师协会老年医学专科医师分会理事</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">北京医师协会<span style="color: black;">安定</span>疗护专业专家委员会委员</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">北京医学会老年医学分会第八届</p>缓和医疗学组委员
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">北京市海淀区肿瘤治疗质量<span style="color: black;">掌控</span>和改进</p>专家组专家委员
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">中国老年医学学会舒缓分会常委</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">北京医学伦理学会<span style="color: black;">安定</span>疗护<span style="color: black;">科研</span>分会委员</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">北京市健康科普专家等</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">从事老年肿瘤内科工作19年，<span style="color: black;">善于</span>老年恶性肿瘤的内科治疗（<span style="color: black;">包含</span>化疗、靶向及免疫治疗等）及终末期的<span style="color: black;">安定</span>疗护。<span style="color: black;">参与<span style="color: black;">发布</span>SCI<span style="color: black;">文案</span>3篇，<span style="color: black;">发布</span>核心期刊<span style="color: black;">文案</span>十余篇，参编《临终关怀与缓和医疗》、《老年医学实践技能进阶培训教程》等书籍。</span></p><img src="https://mmbiz.qpic.cn/mmbiz_png/7aOnNMtZQQskXk3wQnpTWoXJlNRLLNMFIMhtKIaRQkVpFL6creiccZ9EhzUushSw7Pqswu0cTsul312nfzd5lAg/640?wx_fmt=png&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;">
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">出诊地点：</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">门诊大厅一层 肿瘤内科门诊</span></p><img src="https://mmbiz.qpic.cn/mmbiz_png/7aOnNMtZQQskXk3wQnpTWoXJlNRLLNMFXtsWvmricsKExicialQcX7Og3TCYQe4cDqrG7nsEMCw3D7HjWTAxnRWgw/640?wx_fmt=png&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;">
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">出诊时间：</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">周<span style="color: black;">2、</span><span style="color: black;">3、</span>周四上午（普通诊）</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">周五上午（专家诊）</p><a style="color: black;">
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">北京老年医院预约挂号“新攻略”</strong></p>
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<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">点击链接，攻略在手</p>
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