【高尚病例】甲状腺乳头状癌伴淋巴结转移一例
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="//q6.itc.cn/images01/20240522/4412e24a10de46a98c3c82b5bd0d8192.jpeg" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">病史摘要</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">16岁<span style="color: black;">青年</span>女性,3年前<span style="color: black;">发掘</span>右颈部肿块,呈渐进性增大,<span style="color: black;">没</span>发热、<span style="color: black;">没</span>压痛,肿块质硬。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">检测</span>图像</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="//q7.itc.cn/images01/20240522/f586e8a105a04817a1ce20bab7ec2d08.png" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">冠状位融合图</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="//q1.itc.cn/images01/20240522/ae00fc6d821c4e8185f2cef8cb867f72.png" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">轴位融合:甲状腺右叶<span style="color: black;">显著</span>增大、密度不均,糖代谢不均匀轻度<span style="color: black;">升高</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="//q6.itc.cn/images01/20240522/29b6c6e2e52944b984d069af7f49845d.jpeg" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">颈部淋巴结转移</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="//q5.itc.cn/images01/20240522/40f2efeccec243259bcb1acf01f92a87.jpeg" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">肺内多发转移</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="//q6.itc.cn/images01/20240522/573f538576074f649e720986ce4bf229.jpeg" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">肺内多发转移</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="//q2.itc.cn/images01/20240522/5fc3eacc697642bd9a87081c2901603a.jpeg" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">肺内多发转移</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">影像表现</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">a.甲状腺右侧叶、峡部及部分甲状腺左侧叶体积增大,边界模糊,密度不均伴局部钙化,糖代谢不均匀<span style="color: black;">升高</span>,<span style="color: black;">思虑</span>恶性病变;</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">b.双颈多发代谢<span style="color: black;">升高</span>淋巴结,<span style="color: black;">思虑</span>转移;</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">c.双肺多发<span style="color: black;">体积</span>不等结节影,糖代谢<span style="color: black;">升高</span>,<span style="color: black;">思虑</span>肺内多发转移;</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">d.颈部及肋间少许棕色脂肪生理性糖代谢<span style="color: black;">升高</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">病理结果</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="//q2.itc.cn/images01/20240522/ed202664077b43b2bdc9f08772102276.jpeg" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="//q2.itc.cn/images01/20240522/9d14b6a6dd4a43ff9564a1e9727649d1.jpeg" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">核内假包涵体</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">病理结果:甲状腺乳头状癌,淋巴结转移。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">病症概述</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">甲状腺乳头状癌(papillary thyroid carcinoma,PTC)为最<span style="color: black;">平常</span>的甲状腺癌,恶性度较低。约占甲状腺癌的85%,多见于儿童或<span style="color: black;">青年</span>(40岁前)女性。肿瘤生长缓慢,可在甲状腺内局限数年,PTC<span style="color: black;">能够</span>出<span style="color: black;">此刻</span>甲状腺的任何部位,<span style="color: black;">没</span>论是正常部位还是异位部位。<span style="color: black;">亦</span>可能<span style="color: black;">出现</span>在甲状舌管囊肿和畸胎瘤中,<span style="color: black;">包含</span>卵巢甲状腺肿中。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">临床表现</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">该病在<span style="color: black;">初期</span><span style="color: black;">无</span><span style="color: black;">显著</span>症状,到中晚期影响<span style="color: black;">周边</span>或远处<span style="color: black;">要紧</span>器官时,可<span style="color: black;">导致</span>声音嘶哑、<span style="color: black;">呼气</span>困难、吞咽困难等症状 。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">鉴别诊断</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">(1)甲状腺腺瘤:</strong>特征性表现为类圆形低密度或混杂密度肿块,包膜完整,边缘清楚,环状强化和瘤内结节强化。延迟扫描强化范围扩大或等密度强化,高功能腺瘤<span style="color: black;">一般</span>代谢为均匀<span style="color: black;">升高</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">(2)结节性甲状腺肿:</strong>多为类圆形多发低密度结节,包膜完整,边界清晰,密度均匀,<span style="color: black;">加强</span>扫描轻度强化,糖代谢不高。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">治疗与预后</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">手术是治疗的首选方式。<span style="color: black;">初期</span>的甲状腺乳头状癌可做腺叶切除术或甲状腺全切术,中晚期时在全切甲状腺的<span style="color: black;">同期</span>,还需<span style="color: black;">思虑</span><span style="color: black;">周边</span>器官的<span style="color: black;">损害</span>修复问题。<span style="color: black;">针对</span>某些<span style="color: black;">病人</span>,术后还需接受放射性碘131治疗,清除残余甲状腺或手术<span style="color: black;">没</span>法切除的残留病灶,以期降低复发风险、<span style="color: black;">加强</span><span style="color: black;">存活</span>率。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">参考文献等<span style="color: black;">关联</span>资料:</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">1. 临床病理诊断与鉴别诊断.内分泌系统<span style="color: black;">疾患</span>/陈杰主编.一北京:人民卫生出版社,2020.</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2. 王敬敏,李潜,黎海亮.超声引导下细针穿刺细胞学、弹性<span style="color: black;">影像</span>及MRI在诊断甲状腺癌中的应用比较.中国CT和MRI杂志,2018,16(12):37-40.</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">3. 朱长雨, 顾梅, 党受涛, 赵京阳, 李新宇, & 施奕君. (2019). 甲状腺乳头状癌临床病理学特征与braf~(v600e)基因突变<span style="color: black;">关联</span>性<span style="color: black;">科研</span>. 中国实用外科杂志.</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">4. 李宁, 阚艳敏, 李晓松, 王艺桦, 张曼, & 孟健等. (2021). 基于多模态超声的甲状腺乳头状癌决策树模型的构建及其诊断效能<span style="color: black;">评定</span>. 中国全科医学, 24(30), 7.</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">5. ZHOUYueyuan, WANGXian, & HUShudong. (2019). 动态对比<span style="color: black;">加强</span>磁共振<span style="color: black;">影像</span>在甲状腺腺瘤与甲状腺乳头状癌鉴别中的应用. 实用放射学杂志, 35(5), 4.</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">6. 王睿,万海涛,徐鹏.PET/CT在甲状腺乳头状癌术前淋巴转移诊断中的临床<span style="color: black;">科研</span>.航空航天医学杂志, 2014, 025(009):1247-1248.DOI:10.3969/j.issn.2095-1434.2014.09.037.<a style="color: black;"><span style="color: black;">返回<span style="color: black;">外链论坛:http://www.fok120.com/</span>,查看<span style="color: black;">更加多</span></span></a></p>
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