“铁掠夺”治癌症！广东医科大学：揭示癌症治疗新策略
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="//q9.itc.cn/q_70/images03/20240516/3ea3e37eaa464c7a98ba6a009537c197.jpeg" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">作者：Jerry</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">导读：</strong><span style="color: black;">铁<span style="color: black;">针对</span>细胞DNA的合成和修复至关<span style="color: black;">要紧</span>，但<span style="color: black;">太多</span>的游离铁会<span style="color: black;">引起</span>氧化应激，<span style="color: black;">从而</span><span style="color: black;">引起</span>细胞死亡。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">5月13日，广东医科大学<span style="color: black;">科研</span>团队在期刊《Cell Death&Disease》上<span style="color: black;">发布</span>了<span style="color: black;">科研</span>论文，题为“Iron promotes ovarian cancer malignancy and advances platinum resistance by enhancing DNA repair via FTH1/FTL/POLQ/RAD51 axis”。本<span style="color: black;">科研</span>结果证实了铁在卵巢癌中的促癌<span style="color: black;">功效</span>，并揭示了铁<span style="color: black;">经过</span>FTH1/FTL/POLQ/RAD51途径促进DNA<span style="color: black;">损害</span>修复，从而促进铂类耐药的机制。<strong style="color: blue;">本<span style="color: black;">科研</span>结果强调了铁耗竭疗法的<span style="color: black;">要紧</span>性，为推进卵巢癌治疗<span style="color: black;">供给</span>了有<span style="color: black;">期盼</span>的途径。</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="//q0.itc.cn/q_70/images03/20240516/5993375bf2b34ccaa4b90ba0a23b0bb9.jpeg" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">https://www.nature.com/articles/s41419-024-06688-5#Sec28</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">科研</span>背景</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">01</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">卵巢癌是一种<span style="color: black;">平常</span>的妇科恶性肿瘤，其死亡率在所有此类癌症中居于首位。<span style="color: black;">因为</span>病因和发病机制不<span style="color: black;">知道</span>，缺乏高度<span style="color: black;">敏锐</span>的标志物，卵巢癌被<span style="color: black;">叫作</span>为“沉默的杀手”。<span style="color: black;">日前</span>，铂类为<span style="color: black;">基本</span>的化疗是<span style="color: black;">重点</span>的治疗<span style="color: black;">办法</span>，但许多<span style="color: black;">病人</span>会<span style="color: black;">显现</span>铂类耐药，<span style="color: black;">引起</span>治疗失败。<span style="color: black;">科研</span>卵巢癌及其耐药的分子机制<span style="color: black;">针对</span>探索有效的治疗策略至关<span style="color: black;">要紧</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">铁是一种微量元素，其吸收、利用、储存和循环的动态平衡被<span style="color: black;">叫作</span>为铁稳态。细胞<span style="color: black;">经过</span>与转铁蛋白结合来吸收铁，并<span style="color: black;">经过</span>转铁蛋白受体（TFRC）将其内化。大<span style="color: black;">都数</span>铁与硫结合，用于血红蛋白的合成，而多余的铁则储存在铁蛋白（FTH1/FTL）中。多余的铁<span style="color: black;">经过</span>膜蛋白铁转运蛋白（FPN）从细胞中排出。<span style="color: black;">科研</span><span style="color: black;">显示</span>，铁与肿瘤的发展和复发密切<span style="color: black;">关联</span>。癌细胞<span style="color: black;">一般</span><span style="color: black;">拥有</span>较高的铁水平，<span style="color: black;">加强</span>了恶性特征，但<span style="color: black;">太多</span>的铁会促进芬顿反应，<span style="color: black;">增多</span>自由基的产生，<span style="color: black;">引起</span>肿瘤细胞的DNA<span style="color: black;">损害</span>和铁死亡。虽然卵巢癌组织中的铁水平<span style="color: black;">明显</span>高于正常组织，但其在这一背景下的<span style="color: black;">功效</span>尚不清楚。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;"><span style="color: black;">科研</span><span style="color: black;">发展</span></span></strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">02</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">为了证实卵巢癌对铁的依赖性，并探索消除这种<span style="color: black;">疾患</span>的潜在策略，<span style="color: black;">科研</span>人员进行了<span style="color: black;">运用</span><span style="color: black;">各样</span>铁螯合剂的实验。<span style="color: black;">首要</span>，<span style="color: black;">科研</span>人员<span style="color: black;">评定</span>了不同铁螯合剂，<span style="color: black;">包含</span>DFO、M2亚基<span style="color: black;">控制</span>剂和Dp44mT，对细胞存活的<span style="color: black;">控制</span><span style="color: black;">功效</span>。数据清楚地<span style="color: black;">显示</span>，三种铁螯合剂均<span style="color: black;">明显</span>降低了卵巢癌细胞的存活能力。为了确认铁螯合剂的抗癌<span style="color: black;">功效</span>，<span style="color: black;">科研</span>人员<span style="color: black;">评定</span>了卵巢癌细胞的克隆形成和迁移能力。结果<span style="color: black;">显示</span>，已进入临床II期<span style="color: black;">实验</span>的铁螯合剂M2亚基<span style="color: black;">控制</span>剂<span style="color: black;">能够</span>有效降低癌细胞的肿瘤<span style="color: black;">出现</span>能力并减缓其迁移速度。值得<span style="color: black;">重视</span>的是，这些抗癌<span style="color: black;">功效</span>可被铁<span style="color: black;">弥补</span>剂抵消。<span style="color: black;">另外</span>，<span style="color: black;">科研</span>人员进行了细胞周期分析，以<span style="color: black;">科研</span>M2亚基<span style="color: black;">控制</span>剂对卵巢癌细胞的影响。<span style="color: black;">科研</span>结果<span style="color: black;">显示</span>，M2亚基<span style="color: black;">控制</span>剂<span style="color: black;">能够</span><span style="color: black;">增多</span>卵巢癌细胞<span style="color: black;">处在</span>G0/G1期的细胞比例，这<span style="color: black;">显示</span>它可能会影响卵巢癌细胞的DNA复制，<span style="color: black;">引起</span>G0/G1期停滞。<span style="color: black;">另一</span>，细胞凋亡检测<span style="color: black;">表示</span>，M2亚基<span style="color: black;">控制</span>剂治疗<span style="color: black;">明显</span><span style="color: black;">增多</span>了凋亡细胞的数量。<span style="color: black;">况且</span>，铁<span style="color: black;">弥补</span>剂<span style="color: black;">能够</span>减少M2亚基<span style="color: black;">控制</span>剂<span style="color: black;">导致</span>的细胞周期停滞和细胞凋亡<strong style="color: blue;">。这些<span style="color: black;">发掘</span>有力地证实了铁在卵巢癌恶性转化中的促进<span style="color: black;">功效</span>。<span style="color: black;">另外</span>，观察到铁螯合剂<span style="color: black;">能够</span>减缓或<span style="color: black;">控制</span>癌细胞的恶性转化，这<span style="color: black;">显示</span>它们<span style="color: black;">拥有</span><span style="color: black;">做为</span>治疗<span style="color: black;">干涉</span>的<span style="color: black;">潜能</span>。</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="//q7.itc.cn/q_70/images03/20240516/05c9785cc59e45e8bbbfb90cb21e00fa.jpeg" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">铁<span style="color: black;">掠夺</span><span style="color: black;">控制</span>卵巢癌的恶性<span style="color: black;">行径</span> </p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">科研</span>结论</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">03</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">本<span style="color: black;">科研</span>强调了卵巢癌的“铁成瘾”特征以及铁在癌症恶性特性中的促癌<span style="color: black;">功效</span>。<span style="color: black;">另外</span>，铁可降低卵巢癌对铂的<span style="color: black;">敏锐</span>性，而铁螯合剂可<span style="color: black;">加强</span>铂治疗的有效性。从机制上讲，铁<span style="color: black;">经过</span>降低POLQ表达来缓解POLQ对RAD51的<span style="color: black;">控制</span>，促进铂诱导的DNA<span style="color: black;">损害</span>修复。FTH1和FTL调控的铁稳态对铁介导的DNA<span style="color: black;">损害</span>修复至关<span style="color: black;">要紧</span>。基于这些<span style="color: black;">发掘</span>，<span style="color: black;">科研</span>人员提出铁耗竭疗法是消除晚期和铂耐药卵巢癌的一种有<span style="color: black;">期盼</span>的策略。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">参考资料：</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">https://www.nature.com/articles/s41419-024-06688-5#Sec28</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">注：本文旨在介绍医学<span style="color: black;">科研</span><span style="color: black;">发展</span>，<span style="color: black;">不可</span><span style="color: black;">做为</span>治疗<span style="color: black;">方法</span>参考。如需<span style="color: black;">得到</span>健康<span style="color: black;">指点</span>，请至正规医院就诊。</span></p>
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