伊立珠单抗初期临床积极；肿瘤疫苗联合Bevacizumab的结直肠癌临床积极
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="//q2.itc.cn/q_70/images01/20240403/9d9a2422f5f74397a5289a123d942cca.jpeg" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">重要</span>词</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">卡介苗 动力蛋白 溶酶体衔接蛋白SARS-CoV-2 木瓜样蛋白酶 记忆B细胞 ACSL4<span style="color: black;">控制</span>剂 铁死亡 转运蛋白 Raf激酶<span style="color: black;">控制</span>蛋白 贝伐珠单抗(Bevacizumab) 信迪利单抗（Sintilimab） 呋喹替尼（Fruquintinib）伊立珠单抗(Itolizumab)</p>
<h1 style="color: black; text-align: left; margin-bottom: 10px;"><strong style="color: blue;">#今日行业热点#</strong></h1>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">①Science：BCG vaccination reduces bovine tuberculosis transmission, improving prospects for elimination</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">接种卡介苗可<span style="color: black;">经过</span>减少牛结核病的传播而<span style="color: black;">加强</span><span style="color: black;">疾患</span>消除的可能性</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">DOI: 10.1126/science.adl3962</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">②Science：Molecular mechanism of dynein-dynactin complex assembly by LIS1</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">LIS1组装动力蛋白-动力蛋白激活蛋白复合体的分子机制</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">DOI: 10.1126/science.adk8544</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">③Science：Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">基于小鼠模型设计的<span style="color: black;">拥有</span>抗病毒<span style="color: black;">功效</span>的SARS-CoV-2木瓜样蛋白酶<span style="color: black;">控制</span>剂</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">DOI: 10.1126/science.adm9724</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">④Science Advances：Anti-viral memory B cells exhibit enhanced innate immune response facilitated by epigenetic memory</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">表观遗传记忆<span style="color: black;">帮忙</span>了记忆B细胞<span style="color: black;">加强</span>天然免疫反应</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">DOI: 10.1126/sciadv.adk0858</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">⑤Science Advances：Identification of a targeted ACSL4 inhibitor to treat ferroptosis-related diseases</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">靶向ACSL4<span style="color: black;">控制</span>剂用于铁死亡<span style="color: black;">关联</span><span style="color: black;">疾患</span>的鉴定</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">DOI: 10.1126/sciadv.adk1200</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">⑥Science Advances：Cryo-EM structures of the human NaS1 and NaDC1 transporters revealed the elevator transport and allosteric regulation mechanism</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">NaS1和NaDC1转运蛋白结构揭示了电解质在<span style="color: black;">身体</span>的传输和变构调节机制</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">DOI: 10.1126/sciadv.adl3685</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">⑦新一代广谱RAF<span style="color: black;">控制</span>剂XP-102获国家药监局<span style="color: black;">准许</span>开展Ⅰ期临床，拟<span style="color: black;">评定</span>用于治疗BRAF V600突变阳性的晚期实体瘤</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">⑧个体化癌症疫苗GRANITE联合免疫<span style="color: black;">检测</span>点<span style="color: black;">控制</span>剂及氟嘧啶/贝伐珠单抗(Bevacizumab)用于转移性微卫星稳定性结直肠癌<span style="color: black;">病人</span>的Ⅱ/Ⅲ期临床结果积极</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">⑨信迪利单抗（Sintilimab）联合呋喹替尼（Fruquintinib）用于晚期子宫内膜癌<span style="color: black;">病人</span>的新药上市申请已获中国国家<span style="color: black;">药物</span>监督管理局（NMPA）受理并予以优先审评</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">⑩靶向CD6的单克隆抗体伊立珠单抗(Itolizumab)用于狼疮性肾炎<span style="color: black;">病人</span>的Ⅰb期临床EQUALIZE结果积极</p>
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