nqkk58 发表于 2024-6-24 17:03:20

确诊了肠癌，到底能活多久？


    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">按照</span>最新的美国肿瘤<span style="color: black;">病人</span>的统计数据<span style="color: black;">表示</span>（<span style="color: black;">病人</span>数据为2011-2017年，<span style="color: black;">由于</span>要<span style="color: black;">跟踪</span>5年<span style="color: black;">存活</span>率）：</p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">局限性结直肠癌<span style="color: black;">病人</span>（类似于<span style="color: black;">咱们</span>说的<span style="color: black;">初期</span>），5年<span style="color: black;">存活</span>率大约为91%，<span style="color: black;">亦</span><span style="color: black;">便是</span>说能活过5年的概率大约是91%；</p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">区域性结直肠癌<span style="color: black;">病人</span>（类似于<span style="color: black;">咱们</span>说的中期或局部晚期），5年<span style="color: black;">存活</span>率大约为72%；</p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">而一旦有了远处转移（即晚期或转移性结直肠癌），<span style="color: black;">病人</span>的5年<span style="color: black;">存活</span>率骤降至15%。</p>
    <div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://pic2.zhimg.com/80/v2-8af99b9c0e5dca0311ffd956bec1b5b9_720w.webp" style="width: 50%; margin-bottom: 20px;"></div>数据<span style="color: black;">源自</span>：Cancer statistics, 2022<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">但<span style="color: black;">必须</span><span style="color: black;">尤其</span>指出的是，<span style="color: black;">倘若</span><span style="color: black;">病人</span>仅<span style="color: black;">显现</span>了肝转移或肺转移，且判定为可切除或潜在可切除，<span style="color: black;">病人</span>还是有治愈的机会，预期<span style="color: black;">存活</span>远远好于肠癌肝转移不可切除的<span style="color: black;">病人</span>。</p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">而随着晚期结直肠癌基因分型的<span style="color: black;">精细</span>化，以及新药和新治疗<span style="color: black;">方法</span>的<span style="color: black;">持续</span><span style="color: black;">开发</span>和验证，<span style="color: black;">日前</span>即便是晚期结直肠癌<span style="color: black;">病人</span>，经过标准化且<span style="color: black;">连续</span>性的治疗，<span style="color: black;">亦</span>能达到3年、<span style="color: black;">乃至</span>4年的中位总<span style="color: black;">存活</span>期。</p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">一旦确诊晚期结直肠癌，<span style="color: black;">意见</span>尽快进行基因检测，<span style="color: black;">按照</span>不同病理分型<span style="color: black;">选取</span>不同治疗策略。</p>RAS/BRAF野生型，预期<span style="color: black;">存活</span>好，左半<span style="color: black;">选取</span>西妥昔单抗+化疗，右半<span style="color: black;">选取</span>贝伐+化疗（<span style="color: black;">倘若</span>以缩瘤为目的，<span style="color: black;">亦</span>可选择西妥昔单抗联合化疗）RAS突变型，<span style="color: black;">日前</span>KRAS G12C突变<span style="color: black;">已然</span>有相应的靶向<span style="color: black;">药品</span>可供治疗BRAF V600E 突变型，一线为三药化疗±贝伐，二线双靶联合<span style="color: black;">方法</span>（BRAF<span style="color: black;">控制</span>剂+西妥昔单抗）<span style="color: black;">已然</span><span style="color: black;">作为</span>标准MSI-H或dMMR，<span style="color: black;">能够</span><span style="color: black;">不消</span>化疗了，直接<span style="color: black;">运用</span>免疫治疗（帕博利珠单抗 <span style="color: black;">或</span> 纳武利尤单抗±伊匹木单抗）HER2扩增型，抗HER2双靶治疗 <span style="color: black;">或</span> ADC<span style="color: black;">已然</span>可应用于临床治疗<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://pic2.zhimg.com/80/v2-5b39130c9ad9b26d795c66f4e4b02bbd_720w.webp" style="width: 50%; margin-bottom: 20px;"></div>Biller LH,Schrag D. JAMA. 2021;325(7):669 685.<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://pic3.zhimg.com/80/v2-00f46f720bd63b3ead87965e15f0e2be_720w.webp" style="width: 50%; margin-bottom: 20px;"></div>数据<span style="color: black;">源自</span>：Cancer statistics, 2022<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">正如上图所示，不论是男性还是女性，每年<span style="color: black;">由于</span>结直肠癌而死亡的<span style="color: black;">病人</span>人数呈逐年下降的趋势，不仅得益于外科技术和<span style="color: black;">精细</span>治疗从理念转化为真正临床治疗实践的进步，还得益于肠镜等筛查手段的推广和普及。</p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">想<span style="color: black;">认识</span><span style="color: black;">更加多</span>晚期结直肠癌的<span style="color: black;">精细</span>治疗么？</p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">请关注ACEoncology的知乎/<span style="color: black;">微X</span>号，<span style="color: black;">更加多</span>肿瘤<span style="color: black;">关联</span>知识与您分享！</p>
    <div style="color: black; text-align: left; margin-bottom: 10px;"><a style="color: black;"><span style="color: black;"><span style="color: black;">亚太学习班-海外大咖说：RAS 野生型转移性结直肠癌最新诊疗策略 | 文末附幻灯下载~</span><span style="color: black;"><span style="color: black;">​</span>mp</span></span></a>.weixin.qq.com/s?__biz=Mzg5OTY1Njg0Mg==&amp;mid=2247488174&amp;idx=1&amp;sn=81675279ebdd42d057e997c0e7ce1377&amp;chksm=c04eaf4bf739265db55a9884ca93e2ec97b481d85bd4f4f8a5147663b1c41df95841c13db781&amp;token=370079622&amp;lang=zh_CN#rd<span style="color: black;"><img src="https://pic1.zhimg.com/v2-d30d77618dcc7c9352e87b734ea90ccc_180x120.jpg" style="width: 50%; margin-bottom: 20px;"></span></div>
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    <div style="color: black; text-align: left; margin-bottom: 10px;"><a style="color: black;"><span style="color: black;"><span style="color: black;">亚太学习班-海外大咖说：BRAF突变型转移性结直肠癌的最新<span style="color: black;">发展</span> | 文末附幻灯下载​</span><span style="color: black;"><span style="color: black;">​</span>mp.weixin.qq.com/s?__biz=Mzg5OTY1Njg0Mg==&amp;mid=2247488378&amp;idx=1&amp;sn=b11c8bb1fa61544635118e9841162b67&amp;c</span></span></a>hksm=c04eae9ff7392789b0128dc50413774ce506234b01cceef87c590c30c607f894e36675f331d5&amp;token=370079622&amp;lang=zh_CN#rd<span style="color: black;"><img src="https://pic1.zhimg.com/v2-11fce79c6f5d7f0aa5a4568a91880b80_180x120.jpg" style="width: 50%; margin-bottom: 20px;"></span></div>




张露zhang 发表于 2024-8-31 05:15:16

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7wu1wm0 发表于 2024-9-7 09:16:19

你说得对，我们一起加油，未来可期。
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