美国癌协最新信息,新疫苗可让脑癌存活率高达88%!
<span style="color: black;">撰写 Wang | 审核 Rongzi | 排版 Rongzi</span><p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">4月5日至4月10日,美国圣地亚哥举行的美国癌症<span style="color: black;">科研</span>协会(AACR)年会吸引了<span style="color: black;">全世界</span>目光。这是世界上规模最大的癌症<span style="color: black;">科研</span>会议之一,<span style="color: black;">亦</span>是肿瘤学<span style="color: black;">科研</span>和临床<span style="color: black;">发展</span>的<span style="color: black;">全世界</span>交流平台。<span style="color: black;">这次</span>年会以“<span style="color: black;">激励科学、推动进步、革新诊疗</span>”为主题,汇聚了近20000名来自世界各地的癌症<span style="color: black;">科研</span>和治疗<span style="color: black;">行业</span>的专业人士,<span style="color: black;">一起</span>探讨癌症及<span style="color: black;">关联</span>生物医学的最新<span style="color: black;">科研</span>成果。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://mmbiz.qpic.cn/mmbiz_png/mDDbhVdV6GWK1cNWjP0xUYokYvlEuTicdruPfQwIU1CNTibdkZsWPqyB1sYDeVKWcncWHvkZUcqyZAhkDGKZQSgw/640?wx_fmt=png&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">(▲<span style="color: black;">照片</span>来自BIOSPACE官网<span style="color: black;">资讯</span>)</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">在AACR年会上,关于脑肿瘤的<span style="color: black;">科研</span>成果备受关注。<span style="color: black;">始终</span><span style="color: black;">败兴</span>,脑癌都是世界性医学<span style="color: black;">困难</span>,对人来健康构<span style="color: black;">成为了</span>严重威胁。<span style="color: black;">据美国癌症协会统计,在美国,2016年<span style="color: black;">大概</span>23,770人被诊断为脑或脊柱癌,而大约</span><span style="color: black;">16,050人因脑或脊髓肿瘤而不幸<span style="color: black;">逝去</span></span><span style="color: black;">。据中国国家癌症中心2022年数据<span style="color: black;">表示</span>,</span><span style="color: black;">中枢神经系统肿瘤首次进入中国肿瘤<span style="color: black;">病人</span>“发病率最高的十大肿瘤”</span><span style="color: black;">之列,排名第9,死亡率则排名第8。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">在脑癌中,<strong style="color: blue;"><span style="color: black;">胶质母细胞瘤是一种<span style="color: black;">尤其</span><span style="color: black;">拥有</span>侵袭性的脑癌</span></strong>,其携带<strong style="color: blue;"><span style="color: black;">5年<span style="color: black;">存活</span>率极低,仅为10%</span></strong><span style="color: black;">,<span style="color: black;">一般</span><span style="color: black;">病人</span>在确诊之后,<span style="color: black;">存活</span>期较短,大约</span><strong style="color: blue;"><span style="color: black;">存活15至18个月</span></strong><span style="color: black;">。<span style="color: black;">因为</span>其较高的恶性程度和易复发的特性,胶质母</span>细胞瘤的治疗<span style="color: black;">始终</span>是医学界面临的挑战。</p><img src="https://mmbiz.qpic.cn/sz_mmbiz_png/38EGDm9kQCpdl6McKPMvms9wNksAby1DpSZhh24NCXxNTXU6niaDmcuQm7IJxuAcwoTer6zLXUppVVjmKPQShNA/640?wx_fmt=png&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;">
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">胶质母细胞瘤的治疗</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">胶质母细胞瘤(GBM),是星形细胞肿瘤中恶性程度最高的一类胶质瘤。<span style="color: black;">平常</span>于</span><span style="color: black;">50至60岁的人群,其在神经上皮肿瘤中的占比高达22.3%</span><span style="color: black;">。该肿瘤<span style="color: black;">重点</span><span style="color: black;">位置于</span>皮质下,<span style="color: black;">平常</span>于大脑半球的各个区域,其生长方式多为浸润性,易侵犯多个脑叶<span style="color: black;">乃至</span>深部结构,额叶尤为<span style="color: black;">平常</span>。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">GBM治疗的<span style="color: black;">重要</span><span style="color: black;">阻碍</span>是化疗<span style="color: black;">药品</span>或其他抗癌<span style="color: black;">药品</span><span style="color: black;">因为</span>血脑肿瘤屏障(BBTB)而<span style="color: black;">没</span>法到达脑肿瘤,<span style="color: black;">引起</span>细胞毒活性弱和耐药性。<span style="color: black;">另外</span>,<span style="color: black;">因为</span> GBM 肿瘤的异质性,临床<span style="color: black;">准许</span>的抗癌<span style="color: black;">药品</span>数量有限。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">日前</span>,FDA<span style="color: black;">准许</span>可用于治疗 GBM的<span style="color: black;">药品</span>有</span><strong style="color: blue;"><span style="color: black;">替莫唑胺、洛莫司汀、卡莫司汀和贝伐珠单抗</span></strong><span style="color: black;">。</span><span style="color: black;">这些<span style="color: black;">药品</span><span style="color: black;">重点</span>用于治疗复发性高级别神经胶质瘤及其症状。</span><span style="color: black;">遗憾的是,尽管过去 60 年来人们<span style="color: black;">始终</span>在<span style="color: black;">奋斗</span>治疗 GBM,但在延长该<span style="color: black;">疾患</span><span style="color: black;">病人</span>的总<span style="color: black;">存活</span>期 (OS) 方面尚未取得重大<span style="color: black;">发展</span>。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">实质</span>上,关于治疗<span style="color: black;">脑肿瘤</span><span style="color: black;">药品</span>的<span style="color: black;">开发</span>从未停止。在<span style="color: black;">近期</span>的AACR年会上,关于</span><span style="color: black;"><span style="color: black;">脑肿瘤</span><span style="color: black;">病人</span>中的<span style="color: black;">科研</span>成果引人瞩目。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">由Diakonos Oncology<span style="color: black;">开发</span>的</span><span style="color: black;"><strong style="color: blue;">树突状细胞疫苗</strong></span><span style="color: black;">在胶质母细胞瘤<span style="color: black;">病人</span>中的I期<span style="color: black;">科研</span>结果<span style="color: black;">表示</span>出了令人振奋的疗效,数据<span style="color: black;">表示</span>接受该疫苗治疗的<span style="color: black;">病人</span>在</span><strong style="color: blue;"><span style="color: black;">一年后仍有88%的存活率</span></strong><span style="color: black;">!</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://mmbiz.qpic.cn/mmbiz_png/mDDbhVdV6GWK1cNWjP0xUYokYvlEuTicdquUCOBdWAz6eJWaIHfBIBPQ8T8J4gOCx6ibXh5w9eNDhRjtGHYFBAtA/640?wx_fmt=png&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">树突状细胞疫苗<span style="color: black;">做为</span>一种免疫治疗手段,<span style="color: black;">经过</span>激活<span style="color: black;">病人</span><span style="color: black;">自己</span>的免疫系统来攻击肿瘤细胞,<span style="color: black;">拥有</span>独特的<span style="color: black;">优良</span>。</span><span style="color: black;">它不仅<span style="color: black;">能够</span></span><span style="color: black;">针对特定的肿瘤抗原进行精确的打击,<span style="color: black;">还<span style="color: black;">能够</span></span>避免对正常细胞的<span style="color: black;">损害</span>,<span style="color: black;">从而</span>减少副<span style="color: black;">功效</span>的<span style="color: black;">出现</span></span><span style="color: black;">。相比之下,接受标准治疗<span style="color: black;">方法</span>的<span style="color: black;">病人</span>中这一比例仅为53%。这一<span style="color: black;">明显</span>结果为胶质母细胞瘤的治疗带来了新的<span style="color: black;">期盼</span>。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">除此之外,还有多种<span style="color: black;">处在</span>临床<span style="color: black;">科研</span><span style="color: black;">周期</span>的对抗多形性胶质母细胞瘤候选<span style="color: black;">药品</span>。例如,美国马萨诸塞州总医院<span style="color: black;">开发</span>的</span><span style="color: black;"><strong style="color: blue;"><span style="color: black;">CARv3-TEAM-ET细胞</span></strong></span><span style="color: black;">。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">CARv3-TEAM-ET细胞由人体<span style="color: black;">自己</span>收集的免疫细胞(T细胞)制成,这些细胞经过基因改变,<span style="color: black;">传送</span>回<span style="color: black;">身体</span>以杀死癌细胞</span><span style="color: black;">。<span style="color: black;">不外</span>,该项<span style="color: black;">药品</span>尚未<span style="color: black;">得到</span>美国食品和<span style="color: black;">药品</span>管理局 (FDA)<span style="color: black;">准许</span>。在不久的将来,CARv3-TEAM-ET细胞或将<span style="color: black;">作为</span>被FDA认证的用于治疗GBM的最新<span style="color: black;">药品</span>。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://mmbiz.qpic.cn/mmbiz_png/mDDbhVdV6GWK1cNWjP0xUYokYvlEuTicdicdHMM7gSWe0rPeJoXQca7mzbGYUw4FINKvpRrYLAELyNOnuHFWVCVw/640?wx_fmt=png&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">值得<span style="color: black;">重视</span>的是,<span style="color: black;">日前</span>马萨诸塞州总医院针对新型药剂<span style="color: black;">科研</span>正在招募志愿者,这对GBM<span style="color: black;">病人</span>来讲,或许是有效治疗的新机遇。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">倘若</span>您或您的亲人在人生的道路上,</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">没</span>意中碰上了肿瘤癌症、疑难<span style="color: black;">严重</span><span style="color: black;">疾患</span>等,</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">必须</span>向国际医学专家求助的话,<span style="color: black;">意见</span>您联系</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">——</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;">MORE Health(爱医传递)</strong></span></p><img src="https://mmbiz.qpic.cn/mmbiz_jpg/mDDbhVdV6GWB8CAzvfnIcoZiccJZuiaEuibF8xatm73k5Shpf1WYsHxOAnhOZgHgiaeTRDToQdsFtI31mRlibxxeDicQ/640?wx_fmt=other&wxfrom=5&wx_lazy=1&wx_co=1&tp=webp" style="width: 50%; margin-bottom: 20px;"><span style="color: black;"><strong style="color: blue;">拓展阅读:</strong></span><span style="color: black;"><a style="color: black;">FDA<span style="color: black;">准许</span>口服药Duvyzat治疗杜氏肌营养不良症!</a></span><span style="color: black;"><a style="color: black;">这项运动强心肺还防癌,简单</a>易行,越早<span style="color: black;">起始</span>越好!</span><span style="color: black;"><a style="color: black;">这些生活方式与降低全因死亡率及癌症死亡率<span style="color: black;">关联</span>!</a></span><span style="color: black;"><a style="color: black;">新药速递 | 美国FDA在3月<span style="color: black;">准许</span>了<span style="color: black;">那些</span>肿瘤新疗法?</a></span><span style="color: black;"><a style="color: black;">吃素有益健康?这2种“荤食”适量吃,<span style="color: black;">提高</span>免疫还抗癌</a></span>
论坛是一个舞台,让我们在这里尽情的释放自己。 说得好啊!我在外链论坛打滚这么多年,所谓阅人无数,就算没有见过猪走路,也总明白猪肉是啥味道的。 楼主的文章非常有意义,提升了我的知识水平。
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