肿瘤病人服药时期不意见吃西柚
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">肿瘤病人服药<span style="color: black;">时期</span>不<span style="color: black;">意见</span>吃西柚</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">西柚这种<span style="color: black;">果蔬</span>本身一种非常健康的<span style="color: black;">食品</span>，其中<span style="color: black;">有些</span>有效<span style="color: black;">成份</span><span style="color: black;">针对</span>抗癌<span style="color: black;">亦</span>有<span style="color: black;">必定</span>的功效，<span style="color: black;">因此呢</span>西柚本身是一种“健康<span style="color: black;">果蔬</span>”。<span style="color: black;">然则</span><span style="color: black;">针对</span>癌症<span style="color: black;">病人</span><span style="color: black;">来讲</span>，过量食用西柚却很可能使<span style="color: black;">药品</span>治疗的副<span style="color: black;">功效</span><span style="color: black;">明显</span><span style="color: black;">加强</span>、<span style="color: black;">乃至</span><span style="color: black;">引起</span><span style="color: black;">病人</span>死亡!</p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://pic2.zhimg.com/80/v2-7cb3682136c30b1e516c8161f7772f91_720w.webp" style="width: 50%; margin-bottom: 20px;"></div>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">为何</span><span style="color: black;">不可</span>吃西柚？</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">西柚、芹菜，以及一部分的中药(补骨脂、白芷、防风、蛇床子)和香料(花椒)，这些<span style="color: black;">食品</span><span style="color: black;">其中</span>含有一种特殊的物质，这种物质叫呋喃香豆素，而这个呋喃香豆素，正是<span style="color: black;">不可</span>吃西柚的<span style="color: black;">基本</span><span style="color: black;">原由</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">西柚可能<span style="color: black;">引起</span><span style="color: black;">药品</span>不良反应<span style="color: black;">上升</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">呋喃香豆素以及呋喃香豆素的化合物<span style="color: black;">针对</span>CYP3A4有很强的<span style="color: black;">控制</span><span style="color: black;">功效</span>。正常<span style="color: black;">状况</span>下，CYP3A4参与<span style="color: black;">药品</span>的代谢，能够催化将<span style="color: black;">药品</span>排出人体外的反应。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">恰好，这些<span style="color: black;">药品</span>与CYP3A4<span style="color: black;">出现</span><span style="color: black;">功效</span>，进行代谢的位置在小肠，而口服<span style="color: black;">海量</span>的西柚汁<span style="color: black;">或</span>食用西柚，<span style="color: black;">亦</span>会将呋喃香豆素带到人体的这个部位。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">倘若</span>人<span style="color: black;">海量</span>摄入呋喃香豆素，CYP3A4的<span style="color: black;">功效</span>效果被<span style="color: black;">控制</span>，<span style="color: black;">那样</span><span style="color: black;">药品</span>的正常代谢就会受到影响。这<span style="color: black;">寓意</span>着<span style="color: black;">药品</span>会<span style="color: black;">海量</span>囤积在人<span style="color: black;">身体</span>，相当于<span style="color: black;">病人</span><span style="color: black;">连续</span>摄入远超过正常剂量<span style="color: black;">药品</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">亦</span>许会有<span style="color: black;">病人</span>觉得，只是吃<span style="color: black;">有些</span>普通的<span style="color: black;">食品</span>，就能让<span style="color: black;">药品</span>剂量增大，难道不是好事吗?<span style="color: black;">咱们</span>都<span style="color: black;">晓得</span>，<span style="color: black;">药品</span>治疗是有标准的剂量范围的。<span style="color: black;">倘若</span><span style="color: black;">茫然</span>超过这个范围，疗效不<span style="color: black;">必定</span><span style="color: black;">提高</span>，不良反应反倒会非常<span style="color: black;">显著</span>地<span style="color: black;">增多</span>。严重的时候，这种乱用剂量的<span style="color: black;">状况</span>还有可能<span style="color: black;">引起</span><span style="color: black;">病人</span>死亡。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">因此呢</span>，在接受<span style="color: black;">药品</span>治疗的<span style="color: black;">同期</span><span style="color: black;">海量</span>摄入呋喃香豆素，是可能<span style="color: black;">引起</span><span style="color: black;">有些</span>危险的。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">西柚可能降低<span style="color: black;">药品</span>的有效浓度</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">西柚中还含有黄酮类物质，能够<span style="color: black;">控制</span>小肠粘膜上皮细胞的有机阴离子转运肽(OATP)，限制<span style="color: black;">药品</span>的吸收，<span style="color: black;">引起</span><span style="color: black;">身体</span><span style="color: black;">药品</span>浓度减少，疗效变差。这种<span style="color: black;">功效</span>效果，<span style="color: black;">针对</span>非索非那定这类依赖转运的<span style="color: black;">药品</span>的疗效，影响非常大。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">哪部<span style="color: black;">药品</span><span style="color: black;">不可</span>和西柚<span style="color: black;">一块</span>吃</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">按照</span>FDA<span style="color: black;">颁布</span>的信息，在<span style="color: black;">病人</span><span style="color: black;">吃下</span><span style="color: black;">有些</span>口服<span style="color: black;">药品</span>的时候，<span style="color: black;">不可</span>喝西柚汁或吃西柚：</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">●部分镇静催眠药，如地西泮(安定)等;</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">●部分消化系统用药，如奥美拉唑镁肠溶片、多潘立酮片(吗丁啉)等;</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">●部分脑血管药，如尼莫地平片等;</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">●部分抗<span style="color: black;">心率</span>失常药，如盐酸胺碘酮片等;</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">●部分抗组胺药，如非索非那定片等;</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">●部分免疫<span style="color: black;">控制</span>剂，如环孢素软胶囊(新山地明)等。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">●部分降压药，如硝苯地平缓释片、非洛地平缓释片、盐酸维拉帕米缓释片等;</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">●部分降脂药，如辛伐他汀片、阿托伐他汀钙片等;</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">准确<span style="color: black;">来讲</span>，接近50%的临床常用药，都可能会受到呋喃香豆素的影响。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">而<span style="color: black;">针对</span>肿瘤<span style="color: black;">病人</span>，环磷酰胺、异环磷酰胺、他莫昔芬、长春新碱、紫杉醇、多柔比星、克唑替尼、色瑞替尼、埃克替尼、依维莫司、舒尼替尼、拉帕替尼、厄洛替尼、伊马替尼等，<span style="color: black;">非常多</span>治疗肿瘤的常用药都在这个范围内。<span style="color: black;">因此呢</span>，<span style="color: black;">意见</span>肿瘤<span style="color: black;">病人</span>服药<span style="color: black;">时期</span>不要<span style="color: black;">运用</span>西柚，<span style="color: black;">以避免</span>产生更大的<span style="color: black;">药品</span>副<span style="color: black;">功效</span>反应或降低<span style="color: black;">药品</span>有效浓度。不只是西柚，塞维利亚橙、以色列青柚等<span style="color: black;">食品</span><span style="color: black;">由于</span>含有<span style="color: black;">海量</span>呋喃香豆素，<span style="color: black;">亦</span>不<span style="color: black;">意见</span>服药<span style="color: black;">时期</span>食用。</p>
你说得对，我们一起加油，未来可期。 期待楼主的下一次分享！” 回顾历史，我们不难发现：无数先辈用鲜血和生命铺就了中华民族复兴的康庄大道。 你的见解独到，让我受益匪浅，期待更多交流。
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