来自23万乳腺癌病人的随访科研，16种非癌症药物影响了病人的预后！
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">乳腺癌是女性最为<span style="color: black;">平常</span>的癌症，<span style="color: black;">亦</span>是<span style="color: black;">全世界</span>女性癌症死亡的<span style="color: black;">重点</span><span style="color: black;">原由</span>，乳腺癌的发病率随着年龄的增长而<span style="color: black;">增多</span>。乳腺癌<span style="color: black;">病人</span>有很<span style="color: black;">大都是</span>内分泌受体阳性的<span style="color: black;">状况</span>，<span style="color: black;">能够</span><span style="color: black;">长时间</span><span style="color: black;">运用</span>内分泌治疗<span style="color: black;">药品</span>。<span style="color: black;">然则</span><span style="color: black;">非常多</span><span style="color: black;">病人</span><span style="color: black;">亦</span><span style="color: black;">拥有</span>慢性<span style="color: black;">疾患</span>，<span style="color: black;">例如</span>高血压、糖尿病和血脂<span style="color: black;">反常</span>，<span style="color: black;"><strong style="color: blue;">大概30%到70%的乳腺癌<span style="color: black;">病人</span>在确诊的时候<span style="color: black;">身患</span>其他慢性病，并且一半<span style="color: black;">病人</span><span style="color: black;">已然</span>在服用<span style="color: black;">药品</span>（非癌症治疗<span style="color: black;">药品</span>）</strong></span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">咱们</span>都<span style="color: black;">晓得</span><span style="color: black;">药品</span>之间可能会有相互<span style="color: black;">功效</span>，有几项<span style="color: black;">科研</span>报告了<span style="color: black;">关联</span>的流行病学证据，证明阿司匹林或</span><span style="color: black;">非甾体抗炎药</span><span style="color: black;"><span style="color: black;">等非癌症治疗<span style="color: black;">药品</span>，与较低的乳腺癌<span style="color: black;">危害</span>之间存在<span style="color: black;">相关</span>。其他的<span style="color: black;">药品</span>，如</span><span style="color: black;">他汀类</span><span style="color: black;">、β-受体阻滞剂、二甲双胍等则与较低的乳腺癌复发率或较高的<span style="color: black;">存活</span>率<span style="color: black;">关联</span>。<span style="color: black;">亦</span>有几种<span style="color: black;">药品</span>被证明会<span style="color: black;">增多</span>乳腺癌的<span style="color: black;">危害</span>，或与<span style="color: black;">关联</span><span style="color: black;">药品</span>存在相互<span style="color: black;">功效</span>。下面是一项刊登著名学术期刊的<span style="color: black;">科研</span>，统计了法国235368名非转移性乳腺癌女性病人，<span style="color: black;">经过</span><span style="color: black;">关联</span>的分析<span style="color: black;">科研</span><span style="color: black;">那些</span><span style="color: black;">药品</span>与癌症治疗有影响。</span></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://q7.itc.cn/q_70/images03/20240509/9481a6bbe3c642fd88fd3374b07a6319.png" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">参考文献刊例示意图</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">1、</span>记牢影响治疗的16种<span style="color: black;">药品</span></strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">上面说到，这个<span style="color: black;">科研</span>共计纳入了23万名乳腺癌<span style="color: black;">病人</span>，这些<span style="color: black;">病人</span>有12.1%复发或去世，其中6.6%的<span style="color: black;">病人</span>在随访<span style="color: black;">时期</span>去世。中位总<span style="color: black;">存活</span>期是54.6个月，这些<span style="color: black;">病人</span>确诊时的中位年龄是60岁。大<span style="color: black;">都数</span><span style="color: black;">病人</span>确诊时淋巴结都是未转移状态，有85.3%的<span style="color: black;">病人</span>接受了放疗，70.4%的<span style="color: black;">病人</span>接受了内分泌治疗，38.3%的<span style="color: black;">病人</span>接受了化疗。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://q9.itc.cn/q_70/images03/20240509/8c3b8afa9e554242ae7975f82ff60198.png" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">确诊乳腺癌时的合并<span style="color: black;">疾患</span></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">47%的<span style="color: black;">病人</span>确诊时<span style="color: black;">最少</span>存在一种合并症，上面的图示<span style="color: black;">表示</span>了<span style="color: black;">详细</span>的<span style="color: black;">疾患</span>和比例，其中心血管<span style="color: black;">疾患</span>是最为<span style="color: black;">平常</span>的，其次是内分泌和代谢<span style="color: black;">疾患</span>、精神<span style="color: black;">疾患</span>。排在前面三位的合并症为高血压（20.5%）、糖尿病（8.3%）、<span style="color: black;">肥壮</span>（8.2%）。53%的<span style="color: black;">病人</span><span style="color: black;">无</span><span style="color: black;">发掘</span>合并症，其中<span style="color: black;">有些</span><span style="color: black;">病人</span>正在<span style="color: black;">吃下</span>非特异性<span style="color: black;">药品</span>，如维生素、<span style="color: black;">止疼</span>药或性激素、生殖系统调节剂。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">最后在整体的运算和分析后，在288种<span style="color: black;">药品</span>里<span style="color: black;">发掘</span>了32种<span style="color: black;">药品</span>与总<span style="color: black;">存活</span>期和<span style="color: black;">没</span><span style="color: black;">发展</span><span style="color: black;">存活</span>期<span style="color: black;">明显</span><span style="color: black;">关联</span>，其中16种<span style="color: black;">药品</span>与总<span style="color: black;">存活</span>期和<span style="color: black;">没</span><span style="color: black;">发展</span><span style="color: black;">存活</span>期均<span style="color: black;">关联</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">1、八种与总<span style="color: black;">存活</span>期和<span style="color: black;">没</span>病<span style="color: black;">存活</span>期</span><span style="color: black;"><strong style="color: blue;"><span style="color: black;">正<span style="color: black;">关联</span>的<span style="color: black;">药品</span>是：雷贝拉唑、</span><span style="color: black;">阿尔维林</span><span style="color: black;">、阿替洛尔、辛伐他汀、瑞舒伐他汀、雌三醇（阴道或经粘膜）、诺美孕酮和羟丙甲纤维素</span></strong></span>；</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">2、八种与总<span style="color: black;">存活</span>期和<span style="color: black;">没</span>病<span style="color: black;">存活</span>期</span><strong style="color: blue;"><span style="color: black;"><span style="color: black;">负<span style="color: black;">关联</span>的<span style="color: black;">药品</span>是：</span><span style="color: black;">富马酸亚铁</span><span style="color: black;">、泼尼松龙、卡比马唑、普那霉素、奥沙西泮、阿普唑仑、羟嗪和米安舍林</span></span></strong>；</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">重视</span>，<span style="color: black;">这儿</span>正<span style="color: black;">关联</span><span style="color: black;">显示</span>是<span style="color: black;">药品</span>对肿瘤治疗有好的影响，而负<span style="color: black;">关联</span>则是<span style="color: black;">有害</span>的影响，<span style="color: black;">然则</span><span style="color: black;">详细</span>影响的程度，以及能<span style="color: black;">不可</span>继续吃则是<span style="color: black;">必须</span>咨询您的主治<span style="color: black;">大夫</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="//q3.itc.cn/q_70/images03/20240509/bd905d88f32c49ea8d640f6763171446.jpeg" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">源自</span>：摄图网</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">2、</span>结语</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">尽管这个结论是<span style="color: black;">知道</span>的，<span style="color: black;">然则</span><span style="color: black;">亦</span>不是说非癌症<span style="color: black;">药品</span>就<span style="color: black;">不可</span>吃，而是<span style="color: black;">必须</span><span style="color: black;">按照</span><span style="color: black;">状况</span><span style="color: black;">瞧瞧</span>能<span style="color: black;">不可</span><span style="color: black;">选取</span>替代药物，以及是不是间隔一下<span style="color: black;">药品</span><span style="color: black;">吃下</span>时间，<span style="color: black;">尽可能</span>避免不同种类<span style="color: black;">药品</span>的相互影响。这些问题，<span style="color: black;">大众</span><span style="color: black;">能够</span><span style="color: black;">仔细</span>咨询药剂师。以<span style="color: black;">尽可能</span>避免<span style="color: black;">药品</span>相互<span style="color: black;">功效</span>的<span style="color: black;">有害</span>影响。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">参考文献：</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">Elise Dumas, et al., Concomitant medication, comorbidity and survival in patients with breast cancer, Nature Communications, (2024).</p>
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