同样是肺癌靶向药，有人一吃十几年，有人两月耐药，原由在这
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">癌症<span style="color: black;">没</span>法治愈的<span style="color: black;">重要</span>在于，<span style="color: black;">日前</span>已有的<span style="color: black;">药品</span>中，就算疗效再好都会有<span style="color: black;">药品</span>耐药性的<span style="color: black;">显现</span>。尽管<span style="color: black;">药品</span>不可避免地会<span style="color: black;">显现</span>耐药，但<span style="color: black;">咱们</span>仍会<span style="color: black;">发掘</span>，<span style="color: black;">一样</span>是EGFR突变的<span style="color: black;">病人</span>，<span style="color: black;">吃下</span>同一种靶向<span style="color: black;">药品</span>，<span style="color: black;">显现</span>耐药的时间却不同。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">觅健社区的<span style="color: black;">第1</span>位抗癌明星，在2012年确诊肺癌后，<span style="color: black;">吃下</span>靶向药<span style="color: black;">迄今</span><span style="color: black;">已然</span>有12年时间！但有一部分<span style="color: black;">病人</span>在用药短短几个月后就会有<span style="color: black;">疾患</span><span style="color: black;">发展</span>，<span style="color: black;">药品</span><span style="color: black;">没</span>法再<span style="color: black;">掌控</span>癌细胞的侵袭。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">为何</span>这些抗癌药用在一部分<span style="color: black;">病人</span>身上<span style="color: black;">能够</span></span><span style="color: black;"><strong style="color: blue;">“<span style="color: black;">长时间</span>有效”</strong></span><span style="color: black;"><span style="color: black;"><strong style="color: blue;">，</strong></span><span style="color: black;">而还有一部分<span style="color: black;">病人</span>用着用着就会</span></span><span style="color: black;"><strong style="color: blue;">“失效”</strong></span><span style="color: black;">，起不到任何抗肿瘤<span style="color: black;">功效</span>了呢？</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">01 </span></strong></span></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">多个基因突变共存，一种靶向药抗癌难</span></strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">咱们</span>都<span style="color: black;">晓得</span>，癌症<span style="color: black;">病人</span>在确诊之后<span style="color: black;">必须</span>做基因检测，来<span style="color: black;">知道</span>驱动基因突变。</span><span style="color: black;"><strong style="color: blue;">驱动基因</strong></span><span style="color: black;">，顾名思义，<span style="color: black;">便是</span>在肿瘤的<span style="color: black;">出现</span>发展中起<span style="color: black;">重要</span><span style="color: black;">功效</span>的基因变异。这些基因的特异性改变，是肿瘤产生的<span style="color: black;">原由</span>，<span style="color: black;">亦</span>可能是在抗癌治疗后，<span style="color: black;">引起</span>肿瘤的耐药和<span style="color: black;">发展</span>。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">日前</span>，EGFR、ALK是肺癌<span style="color: black;">行业</span><span style="color: black;">科研</span>最为透彻的驱动基因，由此<span style="color: black;">专家</span>们<span style="color: black;">研发</span>了一系列的TKI靶向药，其他如RET、MET、KRAS等驱动基因的面纱近几年<span style="color: black;">亦</span>被<span style="color: black;">逐步</span>揭开，越来越多罕见靶点<span style="color: black;">药品</span>上市。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">但越来越多的<span style="color: black;">科研</span><span style="color: black;">发掘</span>，</span><span style="color: black;"><strong style="color: blue;">EGFR驱动基因突变“不单纯”</strong></span><span style="color: black;">，除了<span style="color: black;">平常</span>的EGFR突变之外，还合并着其他突变基因。</span><span style="color: black;"><strong style="color: blue;">简单的说<span style="color: black;">便是</span>有些EGFR驱动基因并不是单个<span style="color: black;">显现</span>，特殊<span style="color: black;">状况</span>下会有两个或两个以上的突变位点<span style="color: black;">同期</span><span style="color: black;">显现</span></strong></span><span style="color: black;"><span style="color: black;"><strong style="color: blue;">。</strong></span><span style="color: black;">数据<span style="color: black;">表示</span>，在亚洲<span style="color: black;">病人</span>中，20%的EGFR驱动基因存在着“合并突变”。</span></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;">“合并突变”</strong></span><span style="color: black;">的<span style="color: black;">显现</span>，将会给肺癌<span style="color: black;">病人</span>的治疗带来很大的困难。一种靶向<span style="color: black;">药品</span><span style="color: black;">能够</span><span style="color: black;">精细</span>打击一个突变位点。本来，查明单个驱动基因，<span style="color: black;">而后</span><span style="color: black;">运用</span>相应的靶向药就好了。存在“合并突变”的<span style="color: black;">状况</span>下，一种<span style="color: black;">药品</span>可能就<span style="color: black;">没</span>法发挥出疗效。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="//q4.itc.cn/q_70/images03/20240307/5568f5fca0d247fa8b664c3ef8f323f5.jpeg" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">照片</span><span style="color: black;">源自</span>：摄图网</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">如</span>TP53突变 <span style="color: black;">可影响EGFR突变肺癌接受靶向药治疗后的<span style="color: black;">存活</span>预后。<span style="color: black;">针对</span>EGFR突变阳性晚期非小细胞肺癌一线靶向药治疗的<span style="color: black;">病人</span><span style="color: black;">来讲</span>，存在TP53突变<span style="color: black;">引起</span>更低的<span style="color: black;">没</span><span style="color: black;">发展</span><span style="color: black;">存活</span>期(PFS)，预后更差。</span><span style="color: black;"><strong style="color: blue;">在接受一代EGFR靶向药治疗，6个月内<span style="color: black;">出现</span><span style="color: black;">发展</span>的<span style="color: black;">病人</span>相比24个月后<span style="color: black;">出现</span><span style="color: black;">发展</span>的<span style="color: black;">病人</span>，TP53突变的频率更高。</strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;">存在共突变的人群，有天然的耐药<span style="color: black;">原因</span>，只<span style="color: black;">运用</span>一种<span style="color: black;">药品</span>可能<span style="color: black;">没</span>法有效抗癌。</strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">02 </span></strong></span></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">慢性病拖垮免疫功能</span></strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;">慢性病属于病程长且<span style="color: black;">一般</span><span style="color: black;">状况</span>下发展缓慢的<span style="color: black;">疾患</span>，</strong></span><span style="color: black;">如心脏病、中风、高血压、高血脂、慢性<span style="color: black;">呼气</span>系统<span style="color: black;">疾患</span>、慢性肾脏<span style="color: black;">疾患</span>和糖尿病等为<span style="color: black;">平常</span>的慢性病类型。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">做为</span>人体”代谢废物“的过滤器，肾脏器官的<span style="color: black;">要紧</span>性<span style="color: black;">不问可知</span>。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">肿瘤<span style="color: black;">病人</span>接受全身综合治疗过程中，<span style="color: black;">许多</span><span style="color: black;">药品</span>均从肾脏清除、对肾脏功能有<span style="color: black;">必定</span>的影响，<span style="color: black;">包含</span>细胞毒<span style="color: black;">药品</span>、<span style="color: black;">止疼</span>药、抗生素、造影剂、骨<span style="color: black;">守护</span>剂等，例如<span style="color: black;">止疼</span>药和草药肾毒素诱发慢性间质性肾炎和尿路上皮癌。<span style="color: black;">药品</span><span style="color: black;">导致</span>的肾<span style="color: black;">损害</span><span style="color: black;">出现</span>率高达18.3%，其中抗生素肾损害的<span style="color: black;">出现</span>率达36%。</span><span style="color: black;"><strong style="color: blue;">靶向<span style="color: black;">药品</span><span style="color: black;">亦</span>不例外，其肾毒性的<span style="color: black;">出现</span>率、程度、肾损机制因<span style="color: black;">药品</span>而各不相同。</strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="//q1.itc.cn/q_70/images03/20240307/455679b864844b8ea07e2395f893c20f.jpeg" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">照片</span><span style="color: black;">源自</span>：摄图网</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;"><span style="color: black;">倘若</span>有慢性肾脏<span style="color: black;">疾患</span>的<span style="color: black;">显现</span>，<span style="color: black;">首要</span>身体免疫功能将受到很大的<span style="color: black;">损害</span>。尿毒症状态、<span style="color: black;">长时间</span>的透析治疗等<span style="color: black;">引起</span>机体抗氧化防御机制受损，且反应性氧自由基形成<span style="color: black;">增加</span></span><span style="color: black;"><strong style="color: blue;">，</strong></span></span><span style="color: black;"><strong style="color: blue;"><span style="color: black;">引起</span>机体<span style="color: black;">长时间</span><span style="color: black;">处在</span>氧化应激状态，促进肿瘤的<span style="color: black;">出现</span>和<span style="color: black;">发展</span>。</strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">慢性阻塞性肺<span style="color: black;">疾患</span>与肺癌在病因学上<span style="color: black;">拥有</span><span style="color: black;">有些</span><span style="color: black;">一起</span>的危险<span style="color: black;">原因</span>，如吸烟、男性、高龄、遗传易感性、职业和环境<span style="color: black;">原因</span>等，<span style="color: black;">平常</span>于肺癌术后的<span style="color: black;">病人</span>。</span><span style="color: black;"><strong style="color: blue;">有<span style="color: black;">科研</span><span style="color: black;">显示</span>，肺癌合并慢阻肺的<span style="color: black;">病人</span>的死亡<span style="color: black;">危害</span>和<span style="color: black;">疾患</span><span style="color: black;">发展</span><span style="color: black;">危害</span>均显着<span style="color: black;">增多</span>。</strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">03</span></strong></span></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">并发症：肺癌不是一种<span style="color: black;">疾患</span>，而是一类<span style="color: black;">疾患</span></span></strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">肺癌晚期癌细胞发展<span style="color: black;">快速</span>，对人体消耗大，<span style="color: black;">引起</span>大部分<span style="color: black;">病人</span>都比较消瘦，免疫力低下。<span style="color: black;">因此呢</span></span><span style="color: black;"><strong style="color: blue;">晚期肺癌<span style="color: black;">病人</span>常常会<span style="color: black;">显现</span><span style="color: black;">有些</span>并发症，如恶性胸腔积液、感染、血栓、<span style="color: black;">病痛</span>等问题。</strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">恶性胸腔积液是肺癌晚期<span style="color: black;">病人</span>最<span style="color: black;">平常</span>的并发症之一，<span style="color: black;">咱们</span><span style="color: black;">叫作</span>之为</span>“胸水” <span style="color: black;">。约一半以上的肺癌<span style="color: black;">病人</span>都会<span style="color: black;">显现</span>不同程度的胸水，<span style="color: black;">显现</span>胸水的<span style="color: black;">原由</span><span style="color: black;">重点</span>有肺癌<span style="color: black;">出现</span>胸膜转移、结核性胸膜炎或低蛋白血症、肺癌术后等。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">肺癌合并恶性胸水<span style="color: black;">不可</span>完全治愈，不少病人胸水在短期内会反复产生，<span style="color: black;">况且</span><span style="color: black;">逐步</span><span style="color: black;">显现</span>包裹性积液而引流困难，肺部因<span style="color: black;">没</span>法复张，病人可能会<span style="color: black;">显现</span>胸闷、<span style="color: black;">呼气</span>困难。</span><span style="color: black;"><strong style="color: blue;">反复<span style="color: black;">显现</span>的胸水不仅<span style="color: black;">熬煎</span>着癌症<span style="color: black;">病人</span>的身体，<span style="color: black;">亦</span>会大大<span style="color: black;">增多</span><span style="color: black;">病人</span>的心里<span style="color: black;">包袱</span>，<span style="color: black;">乃至</span>可能会降低<span style="color: black;">病人</span>的<span style="color: black;">存活</span>质量及<span style="color: black;">存活</span>期。</strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">04 </span></strong></span></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">心理压力加速病情恶化</span></strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">癌症治疗<span style="color: black;">包含</span>手术、化疗、放疗以及靶向治疗、免疫治疗。它们或<span style="color: black;">经过</span>减少恶性肿瘤细胞的增殖来<span style="color: black;">控制</span>细胞生长，或<span style="color: black;">经过</span>细胞毒性来激活细胞死亡程序，<span style="color: black;">目的</span><span style="color: black;">仅有</span>一个，那<span style="color: black;">便是</span>彻底消除癌细胞。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;">但在癌症治疗的过程中，家属和<span style="color: black;">大夫</span><span style="color: black;">常常</span>会忽略一点：癌症<span style="color: black;">病人</span>在承受着巨大的心理压力。</strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">有<span style="color: black;">科研</span><span style="color: black;">显示</span>，<span style="color: black;">长时间</span><span style="color: black;">处在</span>高压的状态下，<span style="color: black;">常常</span>会使病情恶化，而病情恶化<span style="color: black;">常常</span>会带来更大的压力从而产生了恶性循环，影响癌症<span style="color: black;">病人</span>的治疗效果。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">一项<span style="color: black;">发布</span>在《科学》子刊《Science Translational Medicine》的<span style="color: black;">科研</span><span style="color: black;">表示</span>，来自MD安德森癌症中心的<span style="color: black;">专家</span>们<span style="color: black;">发掘</span>：</span><span style="color: black;"><strong style="color: blue;">压力会<span style="color: black;">增多</span>肺癌的耐药性，并促进癌细胞的生长。</strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">发布</span>在《Nature Medicine》上的<span style="color: black;">科研</span><span style="color: black;">一样</span>验证了上面的观点，精神压力<span style="color: black;">能够</span><span style="color: black;">引起</span>压力激素以及神经递质的分泌<span style="color: black;">错乱</span>，从而影响到抗肿瘤免疫应答，<span style="color: black;">最后</span><span style="color: black;">引起</span>化疗和免疫治疗的效果变差。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">科研</span>人员<span style="color: black;">经过</span>重复社交挫折模型（SD）使小鼠产生精神应激，<span style="color: black;">显现</span><span style="color: black;">长时间</span>焦虑和抑郁的状态。在致癌物诱导的非小细胞肺癌和结直肠癌小鼠模型中，<span style="color: black;">科研</span>人员<span style="color: black;">发掘</span>，与对照组相比，</span><span style="color: black;"><strong style="color: blue;">焦虑和抑郁的状态<span style="color: black;">能够</span>使肿瘤数量<span style="color: black;">增多</span>，阻碍化疗和免疫治疗的效果。</strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">05 </span></strong></span></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">你真的会吃药吗？</span></strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">靶向药<span style="color: black;">由于</span>存在不良反应，尽管<span style="color: black;">一般</span>不严重，但<span style="color: black;">亦</span>让<span style="color: black;">病人</span>饱受<span style="color: black;">熬煎</span>。每到这种时候，都有<span style="color: black;">病人</span>疑问：</span><span style="color: black;"><strong style="color: blue;">暂停服药<span style="color: black;">或</span>少吃一点<span style="color: black;">能够</span>吗？</strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;">当然不<span style="color: black;">能够</span>。</strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">靶向<span style="color: black;">药品</span>的<span style="color: black;">吃下</span>次数和剂量都是经过反复多次的动物以及临床<span style="color: black;">实验</span>才得出的结论，<span style="color: black;">仅有</span>按时按量的<span style="color: black;">吃下</span><span style="color: black;">才可</span>达到稳定的血药浓度，发挥最佳的治疗效果。<span style="color: black;">忽然</span>的增量或<span style="color: black;">减少</span>都会<span style="color: black;">引起</span>血药浓度产生波动，影响药效不说，还会<span style="color: black;">引起</span>耐药性的提早<span style="color: black;">显现</span>，<span style="color: black;">乃至</span>产生严重的<span style="color: black;">药品</span>不良反应。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">按时</span>定量<span style="color: black;">需求</span><span style="color: black;">病人</span>在<span style="color: black;">每日</span>固定的时间，遵医嘱按量<span style="color: black;">吃下</span><span style="color: black;">药品</span>。</strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">除此之外，还需<span style="color: black;">重视</span><span style="color: black;">吃下</span>靶向<span style="color: black;">药品</span><span style="color: black;">时期</span>的<span style="color: black;">膳食</span><span style="color: black;">药品</span>禁忌，如西柚、石榴、杨桃中的柚苷、呋喃香豆素类和类黄酮化合物柑桔素等<span style="color: black;">成份</span>，能<span style="color: black;">控制</span>CYP3A4酶的活性，从而干扰人体对靶向药的吸收利用，影响药效。<span style="color: black;">因此呢</span>吃靶向药<span style="color: black;">时期</span><span style="color: black;">不可</span>同服这些<span style="color: black;">果蔬</span>。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">而<span style="color: black;">有些</span><span style="color: black;">药品</span>如糖皮质激素、利福平、异烟肼、苯妥英、卡马西平、巴比妥类、圣约翰草等则会影响靶向药代谢速度，<span style="color: black;">药品</span>在<span style="color: black;">身体</span>停留的时间过短、浓度过低，靶向药还没来得及对肿瘤产生抗癌<span style="color: black;">功效</span>，就被代谢掉了，使得靶向药的疗效大打折扣。<span style="color: black;">因此呢</span><span style="color: black;">吃下</span>靶向<span style="color: black;">药品</span><span style="color: black;">时期</span>，<span style="color: black;">尽可能</span>避免同服以上<span style="color: black;">药品</span>。若确实<span style="color: black;">必须</span>以上用药，则<span style="color: black;">意见</span>两药的<span style="color: black;">吃下</span>时间<span style="color: black;">最少</span>间隔2小时。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;">结语</strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;"><span style="color: black;">为何</span>有些人用靶向药<span style="color: black;">能够</span><span style="color: black;">长时间</span>不耐药，从基因层面<span style="color: black;">来讲</span>，<span style="color: black;">病人</span></span><span style="color: black;">携带的合并突变越少，则靶向<span style="color: black;">药品</span>就越有效。</span><span style="color: black;">当然，基因的变化<span style="color: black;">咱们</span><span style="color: black;">不可</span>掌控，但做好以下几个方面<span style="color: black;">亦</span>将事半功倍。</span></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;"><span style="color: black;">保持</span>规范化的治疗</span>是<span style="color: black;">第1</span>步，<span style="color: black;">仅有</span>谨遵医嘱按时服药<span style="color: black;">才可</span>有效抗癌。而<span style="color: black;">在<span style="color: black;">恢复</span>治疗方面，<span style="color: black;">无</span>慢性病、并发症的<span style="color: black;">显现</span>会大大减轻<span style="color: black;">病人</span>肉体上的痛苦，降低癌症复发<span style="color: black;">发展</span>的<span style="color: black;">危害</span>。最<span style="color: black;">要紧</span>的一点是保持<span style="color: black;">阳光</span>的<span style="color: black;">心理</span>是抗击癌症最强大的免疫力。</span></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">- 点击关注，<span style="color: black;">更加多</span>抗癌<span style="color: black;">信息</span>在<span style="color: black;">这儿</span> -</span></strong></span></p>
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