30天病灶消失,安徽首例“120万抗癌药”在中国科大附一院完成治疗
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">面对癌症,超<span style="color: black;">太多</span>少钱,你会放弃治疗?</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">10万?50万?100万?</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">山东大学老龄科学团队曾经做过一项,<span style="color: black;">发掘</span>10%的癌症<span style="color: black;">病人</span><span style="color: black;">由于</span>缺钱不得不含泪放弃<span style="color: black;">有些</span>治疗,高达52%的癌症<span style="color: black;">病人</span>有经济<span style="color: black;">危险</span>。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">自从去年六月,售价高达120万元的CAR-T<span style="color: black;">制品</span>——阿基伦塞注射液上市<span style="color: black;">败兴</span>,网上<span style="color: black;">非常多</span>人直呼用不起,<span style="color: black;">日前</span>该药还未进<span style="color: black;">医疗保险</span>,还属于纯自费抗癌<span style="color: black;">药品</span>,<span style="color: black;">不外</span>还是有<span style="color: black;">非常多</span>人付出了昂贵的治疗<span style="color: black;">花费</span>用药,<span style="color: black;">已然</span>超过100位。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><img src="https://mmbiz.qpic.cn/mmbiz_png/dzWr4YTic5MAbg9VgOrA0IrOArJKQdGZotaialch9kXEg10Pt7icoJSqUYxY6RicWxTQXpfxGyhzT4ZfKTdwJSpLmQ/640?wx_fmt=png&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;"></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">1、</span>30天病灶消失,安徽首例“120万抗癌药”治疗成功</strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">近期,据新安晚报<span style="color: black;">报告</span>,七年前,57岁的安徽蚌埠的苏阿姨(化名)<span style="color: black;">由于</span>卵巢占位接受了双侧卵巢子宫附件全切手术,术后病理结果<span style="color: black;">表示</span>弥漫大B细胞淋巴瘤。在确诊后的几年时间里,苏阿姨辗转<span style="color: black;">省内外多家医院进行多轮治疗</span>,但效果都不太理想,病情<span style="color: black;">始终</span>反反复复<span style="color: black;">爆发</span>。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">2022年2月,苏阿姨来到中国科大附一院南区血液内科进行治疗。</span><strong style="color: blue;"><span style="color: black;">入院时苏阿姨面部肿胀<span style="color: black;">病痛</span><span style="color: black;">显著</span>、<span style="color: black;">左侧有一个拳头<span style="color: black;">体积</span>的包块,且<span style="color: black;">呼气</span>不畅,<span style="color: black;">没</span>法躺平<span style="color: black;">休憩</span></span>。</span></strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;"><img src="https://mmbiz.qpic.cn/mmbiz_png/dzWr4YTic5MAbg9VgOrA0IrOArJKQdGZocrOsPFZm588chIpiaM4NClsu4R1nm5wGujjL9G2coNiccDEyW79flg7A/640?wx_fmt=png&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;"></span></strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">治疗前苏阿姨左侧面部肿胀<span style="color: black;">显著</span></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">王兴兵教授介绍,“弥漫大B细胞淋巴瘤是最<span style="color: black;">平常</span>的一种恶性血液肿瘤,是淋巴瘤中最<span style="color: black;">平常</span>的亚型,它在淋巴结中<span style="color: black;">快速</span>生长,常累及脾、肝、骨髓和其他器官,<span style="color: black;">平常</span>症状<span style="color: black;">包含</span>发烧、严重盗汗、体重减轻等。”专家团队<span style="color: black;">思虑</span>到苏阿姨既往多线化疗联合新药及靶向治疗,均未使<span style="color: black;">疾患</span>得到<span style="color: black;">掌控</span>,常规治疗效果极差,经科室讨论,并与苏阿姨及家属积极沟通后,决定进行CAR-T细胞治疗。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><a style="color: black;"><span style="color: black;"><span style="color: black;"><img src="https://mmbiz.qpic.cn/mmbiz_png/dzWr4YTic5MAbg9VgOrA0IrOArJKQdGZoMzlZdYQoEQb7EZMt6u7wF2MGjJUPl7icejkrqzuee2vXQvV3F3l1Ovw/640?wx_fmt=png&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;"></span></span></a></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">外周血白细胞采集前,王兴兵教授再次向苏阿姨讲解治疗流程。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">经过细致的前期准备,2月11日,王兴兵教授团队为苏阿姨进行了外周血白细胞采集术,成功采集白细胞108ml。随后,采集白细胞在2-8摄氏度低温<span style="color: black;">守护</span>下送至生物实验室,T细胞被基因转染及扩增培养成功并经过质量检测合格后送回医院。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">经过预处理,3月7日,团队为苏阿姨回输CAR-T细胞阿基仑赛注射液68ml,输注过程顺利,<span style="color: black;">无</span><span style="color: black;">显现</span>血压降低、血氧饱和度下降等不适。</span><a style="color: black;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">回输10天后,苏阿姨面部包块<span style="color: black;">逐步</span>消失;30天后复查PET-CT提示<span style="color: black;">疾患</span>达到完全缓解(所有<span style="color: black;">目的</span>病灶消失,<span style="color: black;">没</span>新病灶<span style="color: black;">显现</span>,且肿瘤标志物正常,<span style="color: black;">最少</span>维持4周),<span style="color: black;">日前</span>苏阿姨生活逐步恢复如常。</span></strong></span></a></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://mmbiz.qpic.cn/mmbiz_png/dzWr4YTic5MAbg9VgOrA0IrOArJKQdGZoRATkQHOytiaGf4rwn5ZDqKG96WqMiaZZyMZILIJEH4aOPdR7fibiaAqiagA/640?wx_fmt=png&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">治疗后,苏阿姨左侧面部肿胀消退</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">苏阿姨在辗转<span style="color: black;">数年</span>未愈的前提下,竟然“打一针”就治好了癌症?疗效这么好的<span style="color: black;">办法</span>到底是什么?</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">2、</span>一针下去杀死癌细胞,传说中的“CAR-T”疗法<span style="color: black;">到底</span>是啥?</strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">CAR-T疗法是<span style="color: black;">日前</span>最火热的免疫疗法,<span style="color: black;">指的是</span>在<strong style="color: blue;">体外利用基因工程的<span style="color: black;">办法</span>修饰<span style="color: black;">病人</span>外周血T细胞,将T细胞进行改造</strong>,让其<span style="color: black;">持有</span>识别肿瘤细胞表面抗原的特性,在体外进行扩散培养后回输至<span style="color: black;">病人</span><span style="color: black;">身体</span>,以此来起到杀灭癌细胞的效果。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">CAR-T(Chimericantigen receptor T-cell,嵌合抗原受体T细胞)</span></strong><span style="color: black;">并不是流水线批量生产的<span style="color: black;">药品</span>,而是<span style="color: black;">必须</span>针对<span style="color: black;">病人</span><span style="color: black;">状况</span>个性化“定制”的“活的免疫细胞”。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">在实验室,技术人员<span style="color: black;">经过</span>基因工程技术,将在<span style="color: black;">咱们</span><span style="color: black;">身体</span>发挥着免疫<span style="color: black;">功效</span>的T细胞激活,并装上“</span><strong style="color: blue;"><span style="color: black;">定位导航器”CAR(肿瘤嵌合抗原受体)</span></strong><span style="color: black;">,<span style="color: black;">此时</span>的T细胞就<span style="color: black;">再也不</span>是对肿瘤细胞视而不见的“路人”了,而是被升级改<span style="color: black;">导致</span>为超级战士——CAR-T细胞。<span style="color: black;">同期</span></span><span style="color: black;">,</span><span style="color: black;">将备制好的CAR-T细胞在实验室进行扩增后,<span style="color: black;">能够</span>使</span><span style="color: black;">其</span><strong style="color: blue;"><span style="color: black;">从“单兵”变身<span style="color: black;">作为</span>“超级军团”。</span></strong><span style="color: black;"><span style="color: black;">她们</span><span style="color: black;">能够</span><span style="color: black;">精细</span>识别<span style="color: black;">身体</span>肿瘤细胞,并<span style="color: black;">经过</span>免疫<span style="color: black;">功效</span>释放<span style="color: black;">海量</span>的多种效应因子,从而<span style="color: black;">有效</span>地杀灭肿瘤细胞,达到治疗恶性肿瘤的目的。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">王兴兵教授介绍,CAR-T细胞治疗给身处绝境的血液肿瘤<span style="color: black;">病人</span>打开了一扇<span style="color: black;">期盼</span>之门。<span style="color: black;">日前</span>CAR-T<span style="color: black;">重点</span>用于治疗淋巴瘤、白血病、多发性骨髓瘤,随着医学的<span style="color: black;">持续</span>探索,<span style="color: black;">将来</span>有望治疗<span style="color: black;">更加多</span><span style="color: black;">疾患</span>。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">举荐</span>阅读:<a style="color: black;">术后<span style="color: black;">弥补</span>免疫细胞,可重建免疫系统,预防癌症转移复发!</a></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">3、</span>CAR-T细胞治疗不等同于能够治愈癌症</strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">CAR-T细胞治疗真的只是“打一针”<span style="color: black;">那样</span>简单?<span style="color: black;">据说</span>,CAR-T的治疗方式,不是重复吃药、打针,只<span style="color: black;">必须</span>一次静脉输注。看上去简单,<span style="color: black;">然则</span><span style="color: black;">全部</span>过程<span style="color: black;">必须</span>经过白细胞采集、T细胞分选、培养、激活、转导、扩增、收获、<span style="color: black;">制品</span>检测,以及储存、运输、回输等一系列严格<span style="color: black;">繁杂</span>的流程。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">“CAR-T细胞在杀灭肿瘤细胞的过程中,会释放<span style="color: black;">非常多</span>细胞因子,<span style="color: black;">导致</span>发热、肌痛、低血压等炎症反应,<span style="color: black;">必须</span>专业医护人员严密监测和<span style="color: black;">即时</span>处理。”王兴兵教授介绍,<span style="color: black;">日前</span>CAR-T细胞治疗的对象比较小众,<span style="color: black;">通常</span><span style="color: black;">来讲</span>,<span style="color: black;">针对</span>癌症<span style="color: black;">病人</span>,还是优先<span style="color: black;">根据</span>传统常规诊疗<span style="color: black;">办法</span>治疗,当所有常规治疗都已尝试仍旧<span style="color: black;">没</span>效、<span style="color: black;">没</span>法再继续治疗时,才会<span style="color: black;">思虑</span>CAR-T治疗,<span style="color: black;">是不是</span>能够<span style="color: black;">运用</span>这种治疗<span style="color: black;">办法</span>,<span style="color: black;">必须</span><span style="color: black;">大夫</span>进行专业的<span style="color: black;">评定</span>。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">必须</span><span style="color: black;">重视</span>的是,CAR-T细胞治疗<span style="color: black;">能够</span>清除癌细胞,但并不等同于<span style="color: black;">必定</span>能够治愈癌症。<span style="color: black;">科研</span><span style="color: black;">显示</span>,CAR-T治疗对80%的<span style="color: black;">病人</span>有效,50%<span style="color: black;">上下</span>有<span style="color: black;">长时间</span>缓解<span style="color: black;">乃至</span>治愈的机会。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">日前</span>市面上除了120万元的阿基伦塞注射液外,上市的<span style="color: black;">重点</span><span style="color: black;">制品</span>有7款,分别为:</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;">1、Kymirah:47.5万美元</strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">用于治疗滤泡性淋巴瘤,总缓解率86.2%、完全缓解率69.1%.</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><a style="color: black;"><span style="color: black;"><img src="data:image/svg+xml,%3C%3Fxml version=1.0 encoding=UTF-8%3F%3E%3Csvg width=1px height=1px viewBox=0 0 1 1 version=1.1 xmlns=http://www.w3.org/2000/svg xmlns:xlink=http://www.w3.org/1999/xlink%3E%3Ctitle%3E%3C/title%3E%3Cg stroke=none stroke-width=1 fill=none fill-rule=evenodd fill-opacity=0%3E%3Cg transform=translate(-249.000000, -126.000000) fill=%23FFFFFF%3E%3Crect x=249 y=126 width=1 height=1%3E%3C/rect%3E%3C/g%3E%3C/g%3E%3C/svg%3E" style="width: 50%; margin-bottom: 20px;"></span></a></p><span style="color: black;"><span style="color: black;">全世界</span>首款CAR-T<span style="color: black;">制品</span>——诺华Kymriah</span>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;">2、Carvykti(西达基奥仑赛注射液):293万人民币</strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">用于治疗多发性骨髓瘤,总缓解率98%、完全缓解率78%</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;">3、Abecma:43.79万美元</strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">用于治疗多发性骨髓瘤,总缓解率72%、完全缓解率28%</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;">4、Breyanzi:41.03万美元</strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">用于治疗大B细胞淋巴瘤,总缓解率73%、完全缓解率54%</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;">5、Tecartus:39.3万美元</strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">用于治疗复发或难治性套细胞淋巴瘤,总缓解率93%、完全缓解率67%</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;">6、Yescarta:37.3万美元</strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">用于治疗大B细胞淋巴瘤,总缓解率83%、完全缓解解率65%</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;">7、Relma-cel(瑞基奥仑赛注射液):129万人民币</strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">用于治疗大B细胞淋巴瘤,总缓解率75.9%、完全缓解率51.7%</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">大众</span>有<span style="color: black;">无</span><span style="color: black;">发掘</span>以上的<span style="color: black;">制品</span>基本都是针对血液肿瘤的治疗,<span style="color: black;">无</span>实体肿瘤?这正是CAR-T疗法发展的难点,比起“小众”的血液肿瘤,实体肿瘤才是癌症治疗的大头。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">4、</span>向实体瘤进攻,中国专家升级“CAR-T”疗法</strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">CAT-T对实体瘤最大的难点之一<span style="color: black;">便是</span>缺乏有效靶点,实体瘤的抗原在正常组织内<span style="color: black;">亦</span>有表达,<span style="color: black;">拥有</span>很大的脱靶<span style="color: black;">危害</span>,让CAR-T疗法的安全性难以<span style="color: black;">保准</span>。临床上所有的肿瘤中实体瘤占90%,<span style="color: black;">日前</span><span style="color: black;">无</span>任何一款针对实体瘤的CAR-T<span style="color: black;">制品</span>上市。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">5月9日,北京大学肿瘤医院副院长沈琳和合作者<span style="color: black;">颁布</span>了一项临床<span style="color: black;">实验</span>结果,<span style="color: black;">表示</span>出一种新型的疗法——CLDN18.2特异性CAR-T细胞疗法在消化道肿瘤中有巨大的<span style="color: black;">潜能</span>。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">科研</span>共<span style="color: black;">选择</span>了37名癌症<span style="color: black;">病人</span>的数据,其中28名<span style="color: black;">病患</span>胃癌/食管胃结合部腺癌、5名<span style="color: black;">病患</span>胰腺癌,这些<span style="color: black;">病人</span><span style="color: black;">身体</span>均有CLDN18.2蛋白中高度表达。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">首次对这些<span style="color: black;">病人</span>进行CAR-T细胞注射后,观察到的安全性是可接受的,<strong style="color: blue;">接受治疗的<span style="color: black;">病人</span>总缓解率达到了48.6%、<span style="color: black;">疾患</span><span style="color: black;">掌控</span>率达到了73%,胃癌<span style="color: black;">病人</span>中分别为57.1%和75%。</strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">虽然说</span>CAR-T疗法<span style="color: black;">针对</span>部分癌症<span style="color: black;">病人</span>而言是“救命稻草”般的存在,但如此“天价”的<span style="color: black;">药品</span>,<span style="color: black;">非常多</span><span style="color: black;">病人</span>面临着适合却治不起的困境,<span style="color: black;">为何</span>国家还不将CAR-T<span style="color: black;">制品</span>纳入<span style="color: black;">医疗保险</span>?让老<span style="color: black;">大众</span>有药可医的<span style="color: black;">同期</span>用得起药?</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">举荐</span>阅读:<a style="color: black;">抗癌四大法宝:CIK细胞、DC细胞、NK细胞、CTL/TCR,你分得清吗?</a></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">5、</span>如此昂贵的CAR-T<span style="color: black;">制品</span>,<span style="color: black;">为何</span><span style="color: black;">不可</span>进<span style="color: black;">医疗保险</span>?</strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">天价抗癌药进不了<span style="color: black;">医疗保险</span>的<span style="color: black;">原由</span>很现实,<span style="color: black;">亦</span>是太贵了!国家<span style="color: black;">医疗保险</span>DRG付费技术<span style="color: black;">指点</span>组组长郑杰<span style="color: black;">回复</span>指出,高达120万元的抗癌药,<strong style="color: blue;">价格</strong><strong style="color: blue;">远超<span style="color: black;">医疗保险</span>基金承受能力和老<span style="color: black;">大众</span><span style="color: black;">包袱</span>水平,不具备经济性。</strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">说到底就一个字:贵!<span style="color: black;">为何</span>CAR-T疗法这么贵?</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;">1、<span style="color: black;">非常多</span>原料都依靠进口</strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">我国CAR-T<span style="color: black;">制品</span>分化度不高,<span style="color: black;">重要</span>设备、试剂、原材料等<span style="color: black;">非常多</span>都依赖进口,这些成本都是非常<span style="color: black;">昂贵</span>的。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;">2、私人一对<span style="color: black;">必定</span>制</strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">CAR-T疗法是个高度化个性化的疗法,只能一对一“私人订制”,<span style="color: black;">没</span>法大批量的生产。在制作成本上非常<span style="color: black;">昂贵</span>,据山西证券研报<span style="color: black;">发布</span>的数据<span style="color: black;">表示</span>,当前制作工艺生产CAR-T<span style="color: black;">制品</span>的总成本在<strong style="color: blue;">15~30万美元</strong>不等。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">CAR-T<span style="color: black;">制品</span>的<span style="color: black;">面世</span>,<span style="color: black;">没</span>疑是给<span style="color: black;">非常多</span><span style="color: black;">病人</span>带去了新的<span style="color: black;">期盼</span>,但<span style="color: black;">昂贵</span>的<span style="color: black;">花费</span>却<span style="color: black;">亦</span>让<span style="color: black;">非常多</span><span style="color: black;">病人</span>望而却步。<span style="color: black;">亦</span><span style="color: black;">期盼</span>国家能<span style="color: black;">早点</span><span style="color: black;">开发</span>出应用更广泛、价格更亲民的<span style="color: black;">制品</span>,改变癌症<span style="color: black;">病人</span>的困境。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">参考资料:</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">肿瘤医学 120万一针的抗癌药,安徽首位<span style="color: black;">病人</span>治疗成功,<span style="color: black;">一月</span>肿瘤消失,值吗</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;"></span>徐广贤.CAR-T细胞免疫疗法在肿瘤治疗中的<span style="color: black;">科研</span><span style="color: black;">发展</span>.广东医科大学学报,2022,40(02):121-131.</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">Mingzhu Su,Jiahui Lao,et.al.Financial Hardship in Chinese Cancer Survivors.Cancer.Published online Month 00, 2020 in Wiley Online Library.DOI: 10.1002/cncr.32943</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">百万一针的CAR-T疗法:贵在哪?能降价?实体瘤何解?.澎湃<span style="color: black;">资讯</span>.2021.10.28</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">120万一针抗癌药<span style="color: black;">为么</span>进不了<span style="color: black;">医疗保险</span>?国家<span style="color: black;">医疗保险</span>局<span style="color: black;">回复</span>.光明网.2021.12.4</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">用自己的细胞定向消灭肿瘤!安徽首位受益者在中国科大附一院完成治疗.安徽网.2022.5.2</span></p><span style="color: black;"><span style="color: black;">精细</span>医疗引领健康<span style="color: black;">将来</span></span><span style="color: black;">想<span style="color: black;">晓得</span><span style="color: black;">更加多</span>,扫码关注公众号</span><img src="data:image/svg+xml,%3C%3Fxml version=1.0 encoding=UTF-8%3F%3E%3Csvg width=1px height=1px viewBox=0 0 1 1 version=1.1 xmlns=http://www.w3.org/2000/svg xmlns:xlink=http://www.w3.org/1999/xlink%3E%3Ctitle%3E%3C/title%3E%3Cg stroke=none stroke-width=1 fill=none fill-rule=evenodd fill-opacity=0%3E%3Cg transform=translate(-249.000000, -126.000000) fill=%23FFFFFF%3E%3Crect x=249 y=126 width=1 height=1%3E%3C/rect%3E%3C/g%3E%3C/g%3E%3C/svg%3E" style="width: 50%; margin-bottom: 20px;">
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">你若<span style="color: black;">爱好</span>,别忘了点个</span><span style="color: black;">在看</span><span style="color: black;">哦</span></p>
你的话语如春风拂面,让我感到无比温暖。 我赞同你的看法,你的智慧让人佩服,谢谢分享。 同意、说得对、没错、我也是这么想的等。
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