Vet. Microbiol|湖南农业大学动物医学院刘兆颖课题组发掘NMDA受体在伪狂犬病毒感染诱发的免疫掌控中具关键功效
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;"><span style="color: black;">近期</span>，湖南农业大学动物医学院</span></span><span style="color: black;">刘兆颖课题组</span><span style="color: black;"><span style="color: black;">在《</span>Veterinary Microbiology<span style="color: black;">》上<span style="color: black;">发布</span>了一项重要<span style="color: black;">科研</span>成果，揭示了伪狂犬病病毒（</span><span style="color: black;">PRV</span><span style="color: black;">）</span></span><span style="color: black;"><span style="color: black;">怎样</span><span style="color: black;">经过</span></span><span style="color: black;"><span style="color: black;">下调小鼠海马区</span>N-<span style="color: black;">甲基</span><span style="color: black;">-D-</span><span style="color: black;">天冬氨酸</span></span><span style="color: black;">（</span><span style="color: black;">NMDA</span><span style="color: black;">）</span><span style="color: black;"><span style="color: black;">受体的表达，<span style="color: black;">从而</span></span></span><span style="color: black;">调控</span><span style="color: black;">T<span style="color: black;">淋巴细胞的免疫应答，这一<span style="color: black;">发掘</span>为</span><span style="color: black;">PRV</span><span style="color: black;">诱导的神经<span style="color: black;">疾患</span>和免疫<span style="color: black;">控制</span>的</span></span><span style="color: black;"><span style="color: black;">繁杂</span></span><span style="color: black;"><span style="color: black;">病理</span></span><span style="color: black;">过程</span><span style="color: black;"><span style="color: black;">提供了新的</span></span><span style="color: black;">视角和</span><span style="color: black;"><span style="color: black;">理论支撑。</span></span></p>
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<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">PRV</span><span style="color: black;">，<span style="color: black;">做为</span>一种极具破坏力的α</span><span style="color: black;">-</span><span style="color: black;">疱疹病毒，<span style="color: black;">长时间</span><span style="color: black;">败兴</span><span style="color: black;">始终</span>是畜牧业的一大威胁，其在猪群中的高致死率令人瞩目。更令人担忧的是，该病毒还具备感染人类的能力，可<span style="color: black;">诱发</span><span style="color: black;">包含</span>脑炎和视神经炎在内的严重神经系统并发症。尽管<span style="color: black;">专家</span>们已对</span><span style="color: black;">PRV</span><span style="color: black;">的神经毒性及免疫<span style="color: black;">控制</span>特性有所认知，但其<span style="color: black;">怎样</span><span style="color: black;">功效</span>于神经系统中的</span><span style="color: black;">NMDA</span><span style="color: black;">受体，并<span style="color: black;">从而</span>影响免疫系统的<span style="color: black;">详细</span>机制，<span style="color: black;">始终</span>尚未阐明。</span></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">NMDA<span style="color: black;">受体，<span style="color: black;">做为</span>中枢神经系统内关键的兴奋性神经递质受体，其功能<span style="color: black;">反常</span>与多种神经病理状态紧密<span style="color: black;">关联</span>。</span></span><span style="color: black;">课题组</span><span style="color: black;"><span style="color: black;"><span style="color: black;">发掘</span>，</span></span><span style="color: black;"><span style="color: black;">PRV</span><span style="color: black;">感染能够<span style="color: black;">明显</span><span style="color: black;">控制</span>小鼠海马区内</span><span style="color: black;">NMDA</span><span style="color: black;">受体的表达，这一变化与激活的炎症过程紧密相连。进一步的<span style="color: black;">科研</span>则揭示了</span><span style="color: black;">NMDA</span><span style="color: black;">受体功能受阻如<span style="color: black;">安在</span></span><span style="color: black;">PRV</span><span style="color: black;">感染的</span><span style="color: black;">T</span><span style="color: black;">细胞中触发一系列反应，<span style="color: black;">包含</span>促炎细胞因子的累积以及<span style="color: black;">经过</span>促进</span><span style="color: black;">IL-2</span><span style="color: black;">分泌来上调免疫<span style="color: black;">控制</span>因子</span><span style="color: black;">CD25</span><span style="color: black;">基因的转录，从而加剧了免疫<span style="color: black;">控制</span>的效应。</span></span><span style="color: black;">NMDA<span style="color: black;">受体拮抗剂</span><span style="color: black;">MK-801</span></span><span style="color: black;">能<span style="color: black;">加强</span></span><span style="color: black;">PRV<span style="color: black;">对</span><span style="color: black;">T</span><span style="color: black;">淋巴细胞的细胞毒性<span style="color: black;">功效</span>，尽管这种<span style="color: black;">功效</span>并未对</span><span style="color: black;">PRV</span><span style="color: black;">的复制能力产生影响。这一<span style="color: black;">发掘</span></span></span><span style="color: black;">不仅凸显</span><span style="color: black;"><span style="color: black;">了</span>NMDA<span style="color: black;">受体在</span><span style="color: black;">PRV</span><span style="color: black;">感染<span style="color: black;">诱发</span>的免疫<span style="color: black;">控制</span>中<span style="color: black;">装扮</span>的关键</span></span><span style="color: black;">地位</span><span style="color: black;"><span style="color: black;">，</span></span><span style="color: black;"><span style="color: black;">亦</span></span><span style="color: black;"><span style="color: black;">为<span style="color: black;">研发</span>针对</span>PRV<span style="color: black;">感染的新型免疫调节治疗策略<span style="color: black;">供给</span>了新的靶点。</span></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">原文出处：</span>Gong MD, Long JY, Xu WB, Huang CY, Meng SY, Zhang XT, Liu ZY. Effect of pseudorabies virus infection on NMDA receptor expression in mice and its role in immunosuppression. Vet Microbiol. 2024 Aug 13; 297:110216. doi: 10.1016/j.vetmic.2024.110216. Epub ahead of print. PMID: 39151256.</span><a style="color: black;"><span style="color: black;">返回<span style="color: black;">外链论坛： http://www.fok120.com</span>，查看<span style="color: black;">更加多</span></span></a></p>
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