处理癌症还有多远,将来打一针疫苗,就能杀死所有癌细胞吗?
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">近期</span>老有人问:注射一针癌症疫苗,就能杀死人身上所有癌细胞,这种理想离实现还有多远?</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">有一句话叫“理想很丰富,现实很骨感”,这个问题<span style="color: black;">亦</span><span style="color: black;">能够</span><span style="color: black;">这般</span>回答。打一针疫苗就能杀死身上所有的癌细胞这个想法还只是个梦幻,<span style="color: black;">况且</span><span style="color: black;">将来</span><span style="color: black;">亦</span>不可能实现。要<span style="color: black;">晓得</span><span style="color: black;">为何</span>,就耐着性子看完下面的答案,时空通讯将为您抽丝剥茧理清头绪。</p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://pic2.zhimg.com/80/v2-090310122cd1832dd9cab32e8158c7ed_720w.webp" style="width: 50%; margin-bottom: 20px;"></div>
<h2 style="color: black; text-align: left; margin-bottom: 10px;"><span style="color: black;">首要</span>要<span style="color: black;">认识</span>一下什么是癌细胞。</h2>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">人体由<span style="color: black;">海量</span>的体细胞<span style="color: black;">构成</span>,一个人体有40~60万亿个细胞。这些细胞正常的新陈代谢,维持着人体的健康存续。在人的遗传基因中,存在着原癌基因和抑癌基因,这两种基因主导着人体细胞正常新陈代谢。原癌基因主管着细胞分裂和增值周期,人的生长不可缺少;抑癌基因则能防止和<span style="color: black;">控制</span>细胞的不正常增殖,保障机体正常生长。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">人<span style="color: black;">一辈子</span><span style="color: black;">每一个</span>细胞分裂次数在50~60次,全身细胞分裂总次数就有10^16次之多。在这些分裂中,<span style="color: black;">亦</span>有的细胞会<span style="color: black;">出现</span>变异,<span style="color: black;">每一个</span>细胞变异概率为10^-6次,<span style="color: black;">这般</span>,人<span style="color: black;">一辈子</span>整体细胞变异的概率就有10^10次,<span style="color: black;">亦</span><span style="color: black;">便是</span>10亿次之多。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">癌细胞<span style="color: black;">便是</span><span style="color: black;">出现</span>变异的细胞,这种细胞分裂<span style="color: black;">快速</span>,且理论上有<span style="color: black;">没</span>限增殖能力。这样说来还得了,人<span style="color: black;">一辈子</span>细胞变异有10亿次之多,那不就有10亿次患癌症的概率?<span style="color: black;">并不</span>然,人体细胞正常分裂过程,虽然<span style="color: black;">亦</span>会有不少变异细胞,但要转化为癌细胞却很难。</p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://pic3.zhimg.com/80/v2-01d64bb99264d737154bfa1affa142a2_720w.webp" style="width: 50%; margin-bottom: 20px;"></div>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">由于</span>癌细胞并非一次细胞变异就形成的,<span style="color: black;">科研</span><span style="color: black;">显示</span>这种随机突变<span style="color: black;">最少</span><span style="color: black;">必须</span>3~7次,才会转化为癌细胞,绝大<span style="color: black;">都数</span>细胞变异并<span style="color: black;">无</span><span style="color: black;">连续</span>到癌细胞早就一命呜呼了。即便有个别形成的癌细胞,在进入血液后,<span style="color: black;">亦</span>会受到<span style="color: black;">海量</span>白血球的攻击,<span style="color: black;">仅有</span>成功逃脱的癌细胞才有机会壮大发展自己。而癌细胞要形成致病因子,<span style="color: black;">必要</span>发展到10亿个以上,<span style="color: black;">才可</span>够被人体感觉。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">癌细胞增值速度是正常细胞的几十倍。人体细胞分裂周期平均约2.5年,而癌细胞分裂周期为30~40天。正常细胞人的<span style="color: black;">一辈子</span>只能分裂50~60次,癌细胞则<span style="color: black;">没</span>限增殖,号<span style="color: black;">叫作</span>永远不死的永生细胞。这种细胞在人体<span style="color: black;">各样</span>器官<span style="color: black;">海量</span>增殖,挤占正常细胞的地盘,<span style="color: black;">引起</span>正常细胞死亡,组织受到破坏,并<span style="color: black;">经过</span>血管等途径,转移到全身。当癌症<span style="color: black;">病人</span>机体组织大面积坏死、<span style="color: black;">流血</span>,失去正常功能,感染并发症,<span style="color: black;">最后</span>的命运就<span style="color: black;">仅有</span>器官<span style="color: black;">衰尽</span>而亡。</p>
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<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">一个人<span style="color: black;">倘若</span>带有遗传基因缺陷,原癌基因变异或抑癌基因受损等;或受到<span style="color: black;">各样</span><span style="color: black;">理学</span>、化学、生物病毒对人体的侵害,如<span style="color: black;">各样</span>污染,辐射、病毒,常吃<span style="color: black;">有些</span>致癌食品等,<span style="color: black;">引起</span>细胞变异<span style="color: black;">失去控制</span>,<span style="color: black;">病患</span>癌症的<span style="color: black;">危害</span>就会大大<span style="color: black;">加强</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">老年人<span style="color: black;">因为</span>机体抵抗力下降,正常细胞代谢活动会<span style="color: black;">出现</span><span style="color: black;">错乱</span>,<span style="color: black;">病患</span>癌症的<span style="color: black;">危害</span><span style="color: black;">亦</span>就会加大。<span style="color: black;">针对</span>癌症的治疗<span style="color: black;">发掘</span>越早越好,<span style="color: black;">由于</span>癌细胞是以倍数递增的,1个变2个,2个变4个,<span style="color: black;">初期</span><span style="color: black;">发掘</span>,癌细胞少,增殖<span style="color: black;">亦</span>较慢,就好治疗<span style="color: black;">有些</span>,后期癌细胞多了,增值速度就会越来越快,就越难治疗。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">简单计算一下就<span style="color: black;">晓得</span>,当人体达到10亿个细胞才难觉察时,过30~40天就会翻一番,1年就翻了10番,癌细胞达到1万亿个,癌细胞<span style="color: black;">已然</span>是健康细胞的1/40~60了,原发器官还有正常细胞<span style="color: black;">存活</span>之地?还有命活?由此可见,<span style="color: black;">通常</span><span style="color: black;">检测</span>到癌症的<span style="color: black;">病人</span>,不治疗的<span style="color: black;">状况</span>下,<span style="color: black;">存活</span>期大<span style="color: black;">都数</span>不会超过1年。</p>
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<h2 style="color: black; text-align: left; margin-bottom: 10px;">癌症疫苗都有<span style="color: black;">那些</span>种类?</h2>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">癌症疫苗有多种类型,<span style="color: black;">重点</span>有针对<span style="color: black;">引起</span>癌症病毒的疫苗和利用肿瘤细胞抗原的疫苗。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">此刻</span>比较成功的是针对<span style="color: black;">导致</span>癌症病毒的疫苗,即HPV疫苗,这是迄今被FDA(美国食品<span style="color: black;">药物</span>监督局)<span style="color: black;">准许</span>上市的<span style="color: black;">独一</span>抗癌疫苗。这种疫苗<span style="color: black;">重点</span>起到预防宫颈癌的<span style="color: black;">功效</span>,<span style="color: black;">此刻</span><span style="color: black;">已然</span>在100多个国家<span style="color: black;">运用</span>,大大降低了<span style="color: black;">女性</span><span style="color: black;">病患</span>宫颈癌的<span style="color: black;">危害</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">HPV病毒中文名为人乳头瘤病毒,是乳头瘤病毒<span style="color: black;">大众</span>族中的一种。<span style="color: black;">科研</span><span style="color: black;">发掘</span>,有99.7%的宫颈癌<span style="color: black;">是由于</span>感染HPV病毒<span style="color: black;">导致</span>,由此预防了HPV病毒的感染,就大大降低了宫颈癌发病<span style="color: black;">危害</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">但这种疫苗<span style="color: black;">亦</span>不是100%的能够预防宫颈癌<span style="color: black;">出现</span>,<span style="color: black;">由于</span>HPV有100多种类型,高<span style="color: black;">危害</span>的有14种,几乎<span style="color: black;">能够</span><span style="color: black;">引起</span>所有的宫颈癌;最高<span style="color: black;">危害</span>的有两种,即HPV-16型和HPV-18型,可<span style="color: black;">引起</span>约70%的宫颈癌病例。</p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://pic3.zhimg.com/80/v2-b72c8a6490bcb9f243ef5bc333523652_720w.webp" style="width: 50%; margin-bottom: 20px;"></div>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">此刻</span>上市的疫苗有2价苗、4价苗、9价苗等,<span style="color: black;">所说</span>“几价”<span style="color: black;">便是</span>预防几种类型HPV,2价苗<span style="color: black;">便是</span>预防HPV-16型和HPV-18型病毒的。<span style="color: black;">因此呢</span>这些疫苗的预防效果是不<span style="color: black;">同样</span>的,中国2020年<span style="color: black;">已然</span><span style="color: black;">准许</span>了自己<span style="color: black;">开发</span>的2价苗上市,2016年<span style="color: black;">准许</span>了葛兰素史克2价苗上市,<span style="color: black;">针对</span>美国4价苗还在三期临床<span style="color: black;">实验</span>中,大概还要2~3年后<span style="color: black;">才可</span>上市。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">而起到治疗癌症<span style="color: black;">功效</span>的疫苗<span style="color: black;">方法</span>,最<span style="color: black;">重点</span>的<span style="color: black;">便是</span><span style="color: black;">发掘</span>和确认肿瘤细胞的<span style="color: black;">关联</span>抗原,<span style="color: black;">经过</span>提取这些抗原,<span style="color: black;">移植</span>人体激发内部免疫系统释放T细胞等抗体,从而达到<span style="color: black;">经过</span><span style="color: black;">自己</span>免疫系统来消灭癌细胞的目的。但迄今为止,这类疫苗的<span style="color: black;">科研</span>虽有<span style="color: black;">发展</span>,但<span style="color: black;">仅有</span>为数极少的疫苗上市,效果并不<span style="color: black;">显著</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">这是<span style="color: black;">由于</span>人类癌症在种类<span style="color: black;">非常多</span>,<span style="color: black;">各样</span>抗原就有数百种之多,在临床的实验中,有相当多的癌症病患<span style="color: black;">必须</span><span style="color: black;">触及</span>多种抗原,这些抗原只能够激发起微弱的免疫系统反应。<span style="color: black;">况且</span>许多抗原既能够在肿瘤组织上<span style="color: black;">剧烈</span>表达,<span style="color: black;">亦</span>会在正常细胞上表达,<span style="color: black;">这般</span>免疫系统就会误认这是正常现象,很难激起反应。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">为了激发<span style="color: black;">更加多</span>免疫系统反应,就不仅<span style="color: black;">必须</span>合适的抗原,还<span style="color: black;">必须</span>多种刺激信号的<span style="color: black;">协同</span>,<span style="color: black;">这般</span>就大大<span style="color: black;">增多</span>了<span style="color: black;">开发</span>难度。理论上所有的癌症都<span style="color: black;">能够</span><span style="color: black;">经过</span>这种<span style="color: black;">办法</span>得到有效治疗,但要在数百种抗原中筛选出有针对性的新抗原,还要<span style="color: black;">经过</span>其他刺激<span style="color: black;">办法</span>最大限度调动机体免疫系统,谈何容易。<span style="color: black;">长时间</span>实践证明,运气好的,<span style="color: black;">才可</span>够找到一两个突变肿瘤特异性抗原,但这些抗原<span style="color: black;">一般</span>只对<span style="color: black;">少于</span>5%的某类肿瘤有效,且效果很难确定。</p>
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<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">这或许是FDA很难<span style="color: black;">准许</span>此类<span style="color: black;">药品</span>上市的<span style="color: black;">原由</span>吧。<span style="color: black;">始终</span><span style="color: black;">败兴</span>,FDA被认为是世界上最严苛的<span style="color: black;">药物</span>审查<span style="color: black;">公司</span>,迄今除了HPV疫苗,FDA还<span style="color: black;">无</span><span style="color: black;">准许</span>一个其他的抗癌疫苗上市,<span style="color: black;">仅有</span>5个疫苗得到俄罗斯、加拿大、欧洲、韩国、巴西的<span style="color: black;">准许</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">例如</span>美国创业<span style="color: black;">公司</span>Antigenics<span style="color: black;">研发</span>的Oncophage疫苗,在俄罗斯<span style="color: black;">准许</span>上市,临床<span style="color: black;">实验</span>证明反之癌症复发的时间<span style="color: black;">达到</span>2年,但这些数据并<span style="color: black;">无</span>令FDA信服,<span style="color: black;">需求</span>Antigenics<span style="color: black;">机构</span>进行<span style="color: black;">另一</span>一项临床<span style="color: black;">实验</span>,而要做完这个实验<span style="color: black;">必须</span>8~10年的时间,投入还<span style="color: black;">必须</span><span style="color: black;">最少</span>5亿美元。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">有数百个抗癌疫苗或新药都面临Antigenics<span style="color: black;">同样</span>的窘境,<span style="color: black;">因为</span><span style="color: black;">没</span>力承担<span style="color: black;">这般</span>的代价而<span style="color: black;">处在</span>停顿状态。<span style="color: black;">此刻</span>FDA<span style="color: black;">准许</span>上市的抗癌新药有18个,据<span style="color: black;">叫作</span>只占研制中新药的8%,而其他92%的数百种新药<span style="color: black;">将来</span>进入市场的可能性极小。尽管FDA的管理体制<span style="color: black;">能够</span>最大限度<span style="color: black;">保证</span><span style="color: black;">药物</span>的安全性,但<span style="color: black;">有些</span>过于保守做法还是受到行业<span style="color: black;">有些</span>行业专家质疑,<span style="color: black;">需求</span>其改革的呼声<span style="color: black;">亦</span><span style="color: black;">持续</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">总之依靠疫苗来防治日益多发的癌症还任重道远。</p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://pic4.zhimg.com/80/v2-6fd9a3bbace50806eb27734113a08f97_720w.webp" style="width: 50%; margin-bottom: 20px;"></div>
<h2 style="color: black; text-align: left; margin-bottom: 10px;">但不可否认近年来抗癌新药和新<span style="color: black;">办法</span><span style="color: black;">已然</span>取得喜人<span style="color: black;">发展</span>。</h2>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">疫苗当然是<span style="color: black;">将来</span>抗癌的一个发展方向,但除此之外,近年来<span style="color: black;">有些</span>抗癌新药和新的医疗<span style="color: black;">办法</span><span style="color: black;">亦</span>在<span style="color: black;">持续</span>地涌现,由此给予了癌症病人<span style="color: black;">更加多</span>的<span style="color: black;">期盼</span>,有效地<span style="color: black;">提高</span>了<span style="color: black;">她们</span>的<span style="color: black;">存活</span>时间和生活质量,有一部分过去必死<span style="color: black;">没</span>疑的癌症,<span style="color: black;">显现</span>了向慢性病转化的趋势。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">靶向药<span style="color: black;">便是</span>近年来最<span style="color: black;">要紧</span>的癌症治疗<span style="color: black;">药物</span>。其实癌细胞并不难杀死,问题是在杀灭癌细胞的<span style="color: black;">同期</span>,会<span style="color: black;">损害</span>健康细胞,这些癌细胞正是以健康细胞为挡箭牌,让<span style="color: black;">药品</span><span style="color: black;">或</span>治疗手段很难奏效。传统的放疗和化疗<span style="color: black;">便是</span><span style="color: black;">因为</span>这个问题让治疗效果大打折扣。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">靶向药<span style="color: black;">便是</span>在细胞分子水平上,针对<span style="color: black;">已然</span><span style="color: black;">知道</span>的致癌位点设计的治疗<span style="color: black;">药品</span>。这个位点<span style="color: black;">能够</span>精确到肿瘤细胞内部一个特殊的蛋白分子,<span style="color: black;">亦</span><span style="color: black;">能够</span>是一个基因片段。<span style="color: black;">按照</span>这种位点,<span style="color: black;">药品</span>进入人体后就能与特异的致癌位点结合<span style="color: black;">出现</span><span style="color: black;">功效</span>,从而让肿瘤细胞特异性死亡,而不会波及到肿瘤<span style="color: black;">周边</span>的正常组织细胞,这种分子靶向治疗<span style="color: black;">药品</span>又被<span style="color: black;">叫作</span>为“生物导弹”。</p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://pic1.zhimg.com/80/v2-59e493ac1fc322bfbc9325e3f9c3b98c_720w.webp" style="width: 50%; margin-bottom: 20px;"></div>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">这种治疗<span style="color: black;">办法</span><span style="color: black;">处理</span>了过去<span style="color: black;">通常</span>放疗、化疗“杀敌一千自损八百”的后果,还<span style="color: black;">处理</span>了传统<span style="color: black;">办法</span>对广泛转移的晚期癌症<span style="color: black;">病人</span>,束手<span style="color: black;">没</span>策,毫<span style="color: black;">没</span>办法的窘境。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">我有一位亲戚,<span style="color: black;">忽然</span><span style="color: black;">发掘</span><span style="color: black;">病患</span>肺癌,<span style="color: black;">况且</span>是晚期广泛转移,<span style="color: black;">没</span>法手术,<span style="color: black;">大夫</span>判定最多<span style="color: black;">仅有</span>三个月,要家属放弃治疗,能吃吃能玩玩度过最后时光。后来转机来了,经基因检测,<span style="color: black;">发掘</span>有靶向位点,于是采用靶向<span style="color: black;">药品</span>治疗。<span style="color: black;">此刻</span>3年过去了,除了按时服药<span style="color: black;">定时</span><span style="color: black;">检测</span>,基本与正<span style="color: black;">一般人</span><span style="color: black;">没</span>异,各项指标都回归到正常值以内,生活质量丝毫没受到影响。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">当然靶向药并不是所有癌症都有效,<span style="color: black;">必定</span>要有位点。<span style="color: black;">同期</span>癌细胞是很狡猾的,为了应对<span style="color: black;">药品</span><span style="color: black;">功效</span>,就会<span style="color: black;">持续</span>变异,由此靶向药就会产生耐药性,<span style="color: black;">因此呢</span>每过一两年,就<span style="color: black;">必须</span>换新药。靶向药<span style="color: black;">亦</span>有副<span style="color: black;">功效</span>,如有的会<span style="color: black;">引起</span>转氨酶<span style="color: black;">上升</span>等。但这<span style="color: black;">已然</span>比过去常规手术、放化疗强了不知多少倍。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">此刻</span>世界领先的<span style="color: black;">没</span>创立体定向放射技术,<span style="color: black;">亦</span>比过去常规手术、放疗强了<span style="color: black;">非常多</span>。这种<span style="color: black;">办法</span>能够非常精确将放射线集中到癌变病灶,只杀灭癌细胞而不<span style="color: black;">损伤</span>正常组织细胞,比人工手术轻微抖动<span style="color: black;">引起</span>周边组织损害减少了10倍以上,避免了普通放疗对周边组织的损害,还能够防止手术过程肿瘤组织细微脱落<span style="color: black;">引起</span>的种植性转移和血液转移,减少手术并发症<span style="color: black;">危害</span>等。</p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://pic3.zhimg.com/80/v2-07accda0c8799203c152a8838ac6771a_720w.webp" style="width: 50%; margin-bottom: 20px;"></div>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">除此之外,还有基因疗法、饥饿疗法、免疫疗法、癌细胞<span style="color: black;">自s</span>等疗法,这些<span style="color: black;">科研</span>都<span style="color: black;">持续</span>有新的<span style="color: black;">发展</span>,<span style="color: black;">因此呢</span><span style="color: black;">能够</span>预见,人类<span style="color: black;">最后</span>必将克服癌症的威胁,把它从不治之症中剔除。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">当然,<span style="color: black;">针对</span>防治癌症<span style="color: black;">必定</span>要遵从科学的<span style="color: black;">办法</span>,到正规医院<span style="color: black;">遵循</span><span style="color: black;">大夫</span>的<span style="color: black;">意见</span>,不要随意相信<span style="color: black;">有些</span>江湖郎中,社会和网络流传的<span style="color: black;">流言</span>,乱用<span style="color: black;">有些</span>未经科学实验和管理<span style="color: black;">分部</span><span style="color: black;">准许</span>的<span style="color: black;">药品</span>和<span style="color: black;">办法</span>,否则会<span style="color: black;">引起</span>严重后果。<span style="color: black;">例如</span>有些人听说饥饿疗法,就认为少吃东西和营养,就会饿死癌细胞。其实<span style="color: black;">这般</span>癌细胞会更加疯狂的发展,抢走了健康细胞的营养,<span style="color: black;">最后</span>癌细胞活得好好的,饿死的是自己。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">而真正的饥饿疗法是<span style="color: black;">经过</span>医疗手段和<span style="color: black;">药品</span>,截断癌细胞的血液供应,使癌细胞死亡,病灶消除。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">就说到这,如<span style="color: black;">爱好</span>我的<span style="color: black;">文案</span>,请点赞关注。感谢阅读,欢迎讨论。</p>
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