宫颈癌的治疗办法重点有哪些?宫颈癌能治好吗
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">随着近年来宫颈癌治疗技术的<span style="color: black;">持续</span>进步和规范,宫颈癌<span style="color: black;">病人</span><span style="color: black;">经过</span>规范的诊疗就<span style="color: black;">能够</span><span style="color: black;">得到</span>良好的预后。本文总结了治疗宫颈癌的<span style="color: black;">各样</span><span style="color: black;">方法</span>和预后效果,<span style="color: black;">一块</span>来<span style="color: black;">瞧瞧</span>吧。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">1、</span>宫颈癌治疗手段</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">1.手术治疗</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">针对</span>宫颈癌IA-IB2、IIA1期<span style="color: black;">病人</span>,手术治疗是其首选治疗方式。<span style="color: black;">按照</span><span style="color: black;">病人</span>的肿瘤分期、有<span style="color: black;">没</span><span style="color: black;">保存</span>生育需求<span style="color: black;">选取</span>不同的手术方式:宫颈锥切术、根治性宫颈切除术、单纯全子宫切除术或根治性子宫切除术。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">锥切和单纯子宫切除术:<span style="color: black;">保存</span>生育功能者,IA1期淋巴脉管间隙<span style="color: black;">没</span>浸润可行锥切;不<span style="color: black;">保存</span>生育功能者,经锥切确诊的IA1期淋巴脉管间隙<span style="color: black;">没</span>浸润者可行单纯子宫切除术。IA1期伴有淋巴脉管间隙浸润,<span style="color: black;">保存</span>生育者可行锥切加前哨淋巴结显影;不<span style="color: black;">保存</span>生育按IA2处理,行改良根治性子宫切除术加双侧盆腔淋巴结切除术。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">根治性子宫切除术加双侧盆腔淋巴结切除术:是IA2到IB2、IIA1期的首选治疗<span style="color: black;">办法</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">根治性子宫颈切除术:适用于IA2到IB1及部分IB2期<span style="color: black;">保存</span>生育功能者。经阴道广泛子宫颈切除加腹腔镜下淋巴结切除(或前哨淋巴结显影)适用于经仔细筛选的IA2期或IB1期<span style="color: black;">必须</span><span style="color: black;">保存</span>生育功能的<span style="color: black;">病人</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2.放化疗</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">针对</span>狭义概念上的局部晚期(即IB3和IIA2期)及中晚期(即IIB- IVA期)宫颈癌的治疗首选同步放化疗。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="//q3.itc.cn/q_70/images01/20240229/41e381eadbc04673a89c33d0e7f4e743.jpeg" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">宫颈癌放疗<span style="color: black;">包含</span>远距离体外照射和近距离腔内照射,远距离体外照射<span style="color: black;">重点</span>针对宫颈癌原发灶和盆腔蔓延及淋巴转移区域,近距离腔内照射<span style="color: black;">重点</span>照射宫颈癌的原发病灶区域。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">而宫颈癌化疗以顺铂为<span style="color: black;">基本</span>的联合化疗或单用顺铂化疗为主。<span style="color: black;">重点</span>适用于:同步放化疗、姑息化疗和新辅助化疗。<span style="color: black;">意见</span>治疗<span style="color: black;">时期</span><span style="color: black;">能够</span><span style="color: black;">协同</span>口服比诺丁白蛋白肽营养素,添加的是纯分离乳清蛋白,0大豆大蛋白,还<span style="color: black;">尤其</span>添加多种真菌多糖、不饱和脂肪酸、益生菌、多种维生素和矿物质等多种营养物质,<span style="color: black;">弥补</span>全面营养的<span style="color: black;">同期</span><span style="color: black;">加强</span>免疫力,<span style="color: black;">提高</span>体质。还可以改善放化疗副<span style="color: black;">功效</span>(呕吐、恶心),有效升白,提成血小板,长肉,减少病人术后<span style="color: black;">药品</span>痛苦症状。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">2、</span>靶向治疗</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">1. 贝伐单抗</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">是<span style="color: black;">第1</span>个<span style="color: black;">获准</span>用于宫颈癌的靶向<span style="color: black;">药品</span>,早在2014年,美国FDA就<span style="color: black;">准许</span>贝伐单抗联合化疗,用于复发或晚期(转移性)宫颈癌<span style="color: black;">病人</span>的治疗。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">GOG 240<span style="color: black;">科研</span><span style="color: black;">显示</span>,接受靶向药贝伐珠单抗联合治疗,<span style="color: black;">能够</span>显著改善宫颈癌<span style="color: black;">病人</span>的总<span style="color: black;">存活</span>期,且并未<span style="color: black;">导致</span><span style="color: black;">病人</span><span style="color: black;">存活</span>质量的下降。<span style="color: black;">因此呢</span>,《2020 NCCN子宫颈癌临床实践指南》<span style="color: black;">举荐</span>含贝伐珠单抗的联合用药为转移性宫颈癌的首选治疗<span style="color: black;">方法</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2. tisotumab vedotin</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">今年4月,美国FDA<span style="color: black;">已然</span>授予抗体偶联<span style="color: black;">药品</span>优先审查资格,可用于治疗在化疗<span style="color: black;">时期</span>或化疗后病情<span style="color: black;">发展</span>的复发性或转移性宫颈癌<span style="color: black;">病人</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2020年9月在欧洲医学肿瘤学会虚拟大会上<span style="color: black;">颁布</span>的<span style="color: black;">重要</span>II期innovaTV 204<span style="color: black;">科研</span>数据<span style="color: black;">表示</span>,tisotumab vedotin<span style="color: black;">做为</span>一种单药疗法<span style="color: black;">拥有</span><span style="color: black;">明显</span>疗效,可为宫颈癌<span style="color: black;">病人</span><span style="color: black;">供给</span><span style="color: black;">拥有</span>临床<span style="color: black;">道理</span>和持久的客观缓解:总缓解率(ORR)为24%、中位缓解<span style="color: black;">连续</span>时间(DOR)为8.3个月,且安全性可控。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">3、</span>免疫治疗</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">1. Keytruda</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2018年,<span style="color: black;">得到</span>美国FDA加速<span style="color: black;">准许</span>,用于二线治疗复发或转移性宫颈癌<span style="color: black;">病人</span>,<span style="color: black;">详细</span>为:化疗<span style="color: black;">时期</span>或化疗后<span style="color: black;">疾患</span><span style="color: black;">发展</span>、经FDA<span style="color: black;">准许</span>的检测<span style="color: black;">办法</span>证实肿瘤表达PD-L1(合并阳性评分≥1)的复发性或转移性宫颈癌女性,<span style="color: black;">作为</span><span style="color: black;">第1</span>个<span style="color: black;">获准</span>治疗晚期宫颈癌的PD-1免疫疗法。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">来自II期KEYNOTE-158队列E的数据<span style="color: black;">表示</span>,在PD-L1阳性(CPS≥1)<span style="color: black;">病人</span>中,Keytruda治疗的总缓解率(ORR)为14.3%。<a style="color: black;"><span style="color: black;">返回<span style="color: black;">外链论坛:http://www.fok120.com/</span>,查看<span style="color: black;">更加多</span></span></a></p>
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