2023抗癌新突破！治疗型癌症疫苗将于今年9月起步临床实验
注：环宇达康国际医讯更名为<span style="color: black;">全世界</span>肿瘤医讯，请设置星标<span style="color: black;">第1</span>时间获取抗癌<span style="color: black;">新闻</span><p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://mmbiz.qpic.cn/mmbiz_png/5klfMQpnRNgkuuxfMibtkUcLV7Wcs8RLDGuuC0Giax2K9pwGceLv3IwrGXD451TTdkibvN8Uq7L8tmungOWOth2dw/640?wx_fmt=png&wxfrom=5&wx_lazy=1&wx_co=1&tp=webp" style="width: 50%; margin-bottom: 20px;"><img src="https://mmbiz.qpic.cn/mmbiz_gif/qXeGgWfP2VtbVsPZjvFhuKCiaOdicYcibrEwyfFBzvXoy2UhSia710WVHKo4zTRK2TFVUp2DDxu4SoXbcV8Yhd7Bvw/640?wx_fmt=gif&wxfrom=5&wx_lazy=1&tp=webp" style="width: 50%; margin-bottom: 20px;"></p>
<h3 style="color: black; text-align: left; margin-bottom: 10px;"><span style="color: black;">继终结了天花，脊髓灰质炎，全面扼杀在世界范围内肆虐的新冠肺炎后，用新型的mRNA技术制造的个性化疫苗治疗癌症，会<span style="color: black;">作为</span>现实吗？<span style="color: black;">近期</span>，BioNTech生物<span style="color: black;">机构</span>宣布将于2023年9月<span style="color: black;">起始</span>个性化 mRNA 疗法<span style="color: black;">实验</span>，<span style="color: black;">包含</span>癌症疫苗。它们将被施用于<span style="color: black;">初期</span>和晚期癌症<span style="color: black;">病人</span>，旨在刺激免疫系统攻击有癌症细胞，并预防复发。</span></h3>
<h3 style="color: black; text-align: left; margin-bottom: 10px;"><span style="color: black;">2022年10月16日，国外<span style="color: black;">媒介</span>上曾<span style="color: black;">颁布</span>了一篇<span style="color: black;">文案</span>在国内<span style="color: black;">导致</span>巨大轰动。一家名为BioNTech德国生物<span style="color: black;">机构</span>的<span style="color: black;">一起</span>创始人在接受采访时<span style="color: black;">叫作</span>，“在新冠之前，BioNTech<span style="color: black;">始终</span>在<span style="color: black;">科研</span> mRNA 癌症疫苗，正在<span style="color: black;">研发</span>针对肠癌、黑色素瘤和其他癌症类型的治疗型疫苗，可能会在本世纪末之前上市。”</span></h3>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">2023年1月，这家<span style="color: black;">机构</span>再次带来喜讯，BioNTech 将在 2023 年 9 月<span style="color: black;">起步</span><span style="color: black;">包含</span>癌症疫苗在内的临床实验，计划到2030年为<span style="color: black;">病人</span><span style="color: black;">供给</span> 10,000 种疗法，一旦成功，用癌症疫苗治疗癌症的设想将照进现实！</span><img src="https://mmbiz.qpic.cn/mmbiz_jpg/CwkERAMhICyZFtsXhbYcS5MEkqzvyEdmPr9SdP9G16yAiaAnuD3LO8FElHxibQ9qJtEHkibnNol24GicY4nb1vzu9A/640?wx_fmt=jpeg&wxfrom=5&wx_lazy=1&wx_co=1&tp=webp" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;">什么是癌症疫苗？</strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">每一个</span>人小时候都会接种的麻疹和水痘等感染的疫苗。这些疫苗利用弱化或杀死的病毒或细菌，刺激人体产生免疫反应，让免疫系统做好防御这些细菌的准备，<span style="color: black;">能够</span><span style="color: black;">帮忙</span>人们避免感染。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">没</span>论是用于预防传<span style="color: black;">患病</span>还是预防和治疗癌症，疫苗都<span style="color: black;">能够</span><span style="color: black;">经过</span>类似的机制发挥<span style="color: black;">功效</span>：</span><span style="color: black;"><strong style="color: blue;">它们<span style="color: black;">教诲</span>免疫系统将传染性病原体或癌细胞识别为<span style="color: black;">必须</span>消除的外来物质。</strong></span><span style="color: black;">癌细胞表面存在特殊的蛋白质，<span style="color: black;">经过</span>靶向这些蛋白质，免疫系统<span style="color: black;">能够</span>特异性地消除癌细胞，<span style="color: black;">同期</span>不<span style="color: black;">损伤</span>正常的细胞。目的是<span style="color: black;">帮忙</span>治疗癌症或防止其在其他治疗后复发。还有<span style="color: black;">有些</span>疫苗是用来预防某些癌症。</span></p><span style="color: black;"><strong style="color: blue;"><span style="color: black;">全世界</span>已上市的癌症疫苗有<span style="color: black;">那些</span>？</strong></span><strong style="color: blue;">预防性癌症疫苗</strong>MID YEAR SUMMARY<span style="color: black;"><span style="color: black;">有些</span>癌症<span style="color: black;">是由于</span>病毒<span style="color: black;">导致</span>的。有助于预防这些病毒感染的疫苗<span style="color: black;">亦</span>可能有助于预防其中<span style="color: black;">有些</span>癌症。</span><span style="color: black;"><strong style="color: blue;"><span style="color: black;">已<span style="color: black;">获准</span>的预防性癌症疫苗：</span></strong></span><span style="color: black;">人类乳头瘤病毒（HPV）疫苗</span><span style="color: black;">可预防与HPV感染<span style="color: black;">关联</span>的宫颈癌，肛门癌，喉癌，阴道癌，外阴癌和阴茎癌。</span><span style="color: black;">HBV疫苗</span><span style="color: black;">预防与HBV感染<span style="color: black;">关联</span>的肝癌。</span><strong style="color: blue;">治疗性癌症疫苗</strong>MID YEAR SUMMARY<span style="color: black;">
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">目的是唤醒免疫系统对<span style="color: black;">身体</span>的癌细胞发起攻击。</p>
</span><span style="color: black;"><strong style="color: blue;"><span style="color: black;">已<span style="color: black;">获准</span>的治疗性癌症疫苗：</span></strong></span><span style="color: black;">Sipuleucel-T（Provenge）：FDA<span style="color: black;">准许</span>的首个治疗性树突细胞疫苗，用于治疗激素疗法耐药的晚期前列腺癌。</span><span style="color: black;">Talimogene laherparepvec（T-VEC）：FDA<span style="color: black;">准许</span>的首款溶瘤病毒疫苗，用于治疗晚期黑色素瘤。它<span style="color: black;">是由于</span>疱疹病毒制成的，能够产生细胞因子，可<span style="color: black;">加强</span>免疫系统，并在<span style="color: black;">短期</span>内<span style="color: black;">导致</span>流感样症状。</span>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;"><span style="color: black;">疾患</span><span style="color: black;">掌控</span>率高达67%！mRNA癌症疫苗成功清除癌细胞</span></strong></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">大众</span>都很关心这则<span style="color: black;">资讯</span>中的主角-mRNA癌症疫苗<span style="color: black;">到底</span>是何方神圣呢？<span style="color: black;">咱们</span>在BioNTech的官网上查到，正如其在<span style="color: black;">资讯</span>中所说，这家生物<span style="color: black;">机构</span><span style="color: black;">始终</span>在做mRNA癌症疫苗的<span style="color: black;">关联</span><span style="color: black;">科研</span>，<span style="color: black;">日前</span>针对不同的癌症类型，如：</span><span style="color: black;"><strong style="color: blue;">非小细胞肺癌、卵巢癌、头颈癌、前列腺癌和黑色素瘤等</strong></span><span style="color: black;">，<span style="color: black;">开发</span>了多款mRNA疫苗。</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="https://mmbiz.qpic.cn/mmbiz_png/CwkERAMhICwfw0765iagbZRqZZVz1WGibbJnfZ1LagwevxeAficMJagK8G1EPjudvxa5M6MwV0gC4zzfHqP4CKkCw/640?wx_fmt=png&tp=webp&wxfrom=5&wx_lazy=1&wx_co=1" style="width: 50%; margin-bottom: 20px;"></p>
<h1 style="color: black; text-align: left; margin-bottom: 10px;"><span style="color: black;"><span style="color: black;">在2022年ESMO大会，<span style="color: black;">颁布</span>了其代号为BNT211的</span>CAR T 细胞疗法联合其</span></h1>
<h1 style="color: black; text-align: left; margin-bottom: 10px;"><span style="color: black;"><span style="color: black;">编码Claudin-6 (CLDN6) 的mRNA疫苗</span>的最新数据<span style="color: black;">，结果非常振奋人心！</span></span></h1>
<h1 style="color: black; text-align: left; margin-bottom: 10px;"><span style="color: black;">21 名不同的晚期癌症<span style="color: black;">病人</span>的疗效<span style="color: black;">评定</span><span style="color: black;">表示</span>，最佳总缓解率 (ORR) 为 </span><span style="color: black;"><strong style="color: blue;">33%</strong></span><span style="color: black;">，<span style="color: black;">疾患</span><span style="color: black;">掌控</span>率 (DCR) 为 </span><span style="color: black;"><strong style="color: blue;">67%</strong></span><span style="color: black;">，其中</span><span style="color: black;"><strong style="color: blue;">1名完全缓解（CR）</strong></span><span style="color: black;">、6名部分缓解（PR）和7名<span style="color: black;">病人</span>病情稳定（SD）。这<span style="color: black;">寓意</span>着，超过</span><span style="color: black;"><strong style="color: blue;">60%的<span style="color: black;">病人</span>病情<span style="color: black;">掌控</span>稳定或<span style="color: black;">明显</span>缩小30%以上，<span style="color: black;">乃至</span>完全消失</strong></span><span style="color: black;">！</span></h1><span style="color: black;"><span style="color: black;">例如</span>这位幸运的<span style="color: black;">病人</span>，61岁的晚期睾丸癌男性，接受了6线化疗<span style="color: black;">方法</span>失败后，肿瘤转移至肺等多部位。幸运的是，接受治疗后，仅12周，肺部的转移灶<span style="color: black;">所有</span>消失，评效达到完全缓解的状态。</span><img src="https://mmbiz.qpic.cn/mmbiz_png/CwkERAMhICzVUGBf60DNym3zOId48nm0GKab2E0ib248eMu68w1UNjorEZHTdOzz45CibvPFXt4lOFOdWzpUnzZA/640?wx_fmt=png&wxfrom=5&wx_lazy=1&wx_co=1&tp=webp" style="width: 50%; margin-bottom: 20px;">
<h1 style="color: black; text-align: left; margin-bottom: 10px;"><span style="color: black;"><span style="color: black;">咱们</span><span style="color: black;">亦</span>期待癌症疫苗的<span style="color: black;">关联</span>疗法能<span style="color: black;">早点</span><span style="color: black;">颁布</span><span style="color: black;">更加多</span>卓越数据，尽快上市，造福<span style="color: black;">更加多</span><span style="color: black;">病人</span>！</span></h1><span style="color: black;"><strong style="color: blue;">“打一针”治疗癌症会<span style="color: black;">作为</span>现实吗？</strong></span>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">相信这是<span style="color: black;">大众</span>最关心的一个问题，</span><span style="color: black;"><span style="color: black;">能够</span>告诉<span style="color: black;">大众</span>的是，<span style="color: black;">日前</span><span style="color: black;"><span style="color: black;">全世界</span>癌症“ 治疗性疫苗 ” <span style="color: black;">开发</span>遍地开花，针对各类癌症的癌症疫苗纷纷<span style="color: black;">面世</span>，并取得了令人振奋的临床数据。如：</span></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">1.</span><span style="color: black;"><strong style="color: blue;">肺癌疫苗--<span style="color: black;">Tedopi</span></strong></span><span style="color: black;"><span style="color: black;">能够</span>破解PD-1耐药，<span style="color: black;">原文链接：</span><a style="color: black;">重磅！新型肺癌疫苗TedopiⅢ期<span style="color: black;">实验</span>数据<span style="color: black;">颁布</span>，竟能破解PD-1耐药！</a></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">2.</span><span style="color: black;"><strong style="color: blue;">乳腺癌疫苗--GP2</strong></span><span style="color: black;">，<span style="color: black;">五年<span style="color: black;">没</span>病<span style="color: black;">存活</span>率高达100%轰动<span style="color: black;">全世界</span>！</span></span><span style="color: black;">原文链接：</span><a style="color: black;"><span style="color: black;">刚才</span>！癌症疫苗取得重大突破！乳腺癌<span style="color: black;">病人</span>五年<span style="color: black;">没</span>病<span style="color: black;">存活</span>率高达100%</a></p><img src="https://mmbiz.qpic.cn/mmbiz_jpg/CwkERAMhICyeReFOx29JiaVJEsCHoLJQibZUSOKkPtwuhtsKUAfueKt9icbCqxcHDwlqL2YPXK9ppUl7GYyvh3zcw/640?wx_fmt=jpeg&wxfrom=5&wx_lazy=1&wx_co=1&tp=webp" style="width: 50%; margin-bottom: 20px;">
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">3.古巴肺癌疫苗Cimavax联合O药延长<span style="color: black;">存活</span>期至13.7个月。原文链接：</span><a style="color: black;">重磅！美国开展肺癌疫苗CIMAvax联合纳武单抗的二期临床<span style="color: black;">实验</span>！</a></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">4.值得国内病友们骄傲的是，<span style="color: black;">咱们</span>国家的<span style="color: black;">研究</span>团队<span style="color: black;">亦</span>在<span style="color: black;">持续</span><span style="color: black;">开发</span>前沿的治疗性疫苗。<span style="color: black;">中国<span style="color: black;">开发</span>的新抗原树突细胞疫苗<span style="color: black;">让胃癌<span style="color: black;">病人</span>治疗1年全身肿瘤消退！</span></span></span><span style="color: black;">原文链接：</span><a style="color: black;">治疗1年全身肿瘤消退！首位接受新型癌症疫苗的晚期胃癌<span style="color: black;">病人</span>持久缓解</a></p><img src="https://mmbiz.qpic.cn/mmbiz_png/CwkERAMhICynnNdWlGjSOA1tHtv264nS5xicuqaJgicib1mIEtBzZ79nibh4PrXlpBfqGwq4xJsec0qc9iaWn0zOxIw/640?wx_fmt=png&wxfrom=5&wx_lazy=1&wx_co=1&tp=webp" style="width: 50%; margin-bottom: 20px;">
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">另外</span>针对各类癌症的疫苗还有<span style="color: black;">非常多</span>，<span style="color: black;">因为</span>篇幅<span style="color: black;">原由</span>不<span style="color: black;">这里</span>一一介绍，<span style="color: black;">国内<span style="color: black;">亦</span>有众多新抗原树突细胞疫苗的<span style="color: black;">科研</span>，<strong style="color: blue;"><span style="color: black;">想<span style="color: black;">认识</span>新抗原疫苗及其他国内外治疗新技术<span style="color: black;">帮忙</span>，且经济<span style="color: black;">前提</span><span style="color: black;">准许</span>的<span style="color: black;">状况</span>下，<span style="color: black;">能够</span>先将病历提交至<span style="color: black;"><span style="color: black;">全世界</span>肿瘤<span style="color: black;">大夫</span>网医学部（400-666-7998）</span>进行初步<span style="color: black;">评定</span>。</span></strong></span></span></p><span style="color: black;"><strong style="color: blue;">癌症疫苗终将<span style="color: black;">作为</span>人类<span style="color: black;">解决</span>癌症的一把<span style="color: black;">利刃</span>！</strong></span>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">人类在漫长的历史长河中，为了摆脱毁灭性的<span style="color: black;">疾患</span>挑战，<span style="color: black;">持续</span><span style="color: black;">开发</span>各类疫苗，才得以终结肆虐的天花、脊椎灰质炎等致命<span style="color: black;">疾患</span>。而<span style="color: black;">针对</span>癌症这个全世界的公敌，医学界<span style="color: black;">亦</span>在积极<span style="color: black;">开发</span><span style="color: black;">各样</span>疫苗，<span style="color: black;">期盼</span><span style="color: black;">亦</span>能在</span><span style="color: black;"><strong style="color: blue;">注射后，能够唤醒<span style="color: black;">咱们</span>的免疫系统重新试别和杀伤癌细胞，<span style="color: black;">同期</span>产生免疫记忆反应，让免疫系统能够在<span style="color: black;">将来</span>十年<span style="color: black;">乃至</span><span style="color: black;">一辈子</span>中<span style="color: black;">连续</span><span style="color: black;">守护</span><span style="color: black;">咱们</span>，每当<span style="color: black;">身体</span><span style="color: black;">显现</span>癌细胞的时候，免疫系统都能自动发起攻击，使其在形成肿瘤之前就杀死它们，<span style="color: black;">守护</span><span style="color: black;">咱们</span>远离癌症</strong></span><span style="color: black;">！</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">就像BioNTech的创始人Türeci 接受采访时说的，“对这项工作仍然持<span style="color: black;">小心</span>态度。<span style="color: black;">做为</span><span style="color: black;">专家</span>，<span style="color: black;">咱们</span>总是不愿说<span style="color: black;">咱们</span>将治愈癌症，但<span style="color: black;">咱们</span><span style="color: black;">已然</span>有<span style="color: black;">有些</span>突破，<span style="color: black;">咱们</span>将继续<span style="color: black;">奋斗</span>。”</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">咱们</span><span style="color: black;">亦</span>愿意相信，在<span style="color: black;">全世界</span><span style="color: black;">研究</span>人员的<span style="color: black;">一起</span><span style="color: black;">奋斗</span>下，这一设想终将照进现实！</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">参考资料：</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">https://www.cnbc.com/2023/01/06/biontech-says-it-will-start-cancer-vaccine-trials-in-the-uk-from-september.html</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">本文为<span style="color: black;">全世界</span>肿瘤<span style="color: black;">大夫</span>网原创，未经授权严禁转载</span></strong></p>
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