c(RGDfC)与c(RGDfK(Mpa)) 哪个更好用？
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">咱们</span>的客户经常从事RGD环肽键和到纳米材料上的科学<span style="color: black;">科研</span>， RGD环肽键和到材料上，最<span style="color: black;">平常</span>的缩合办法是EDC/NHS （<span style="color: black;">亦</span><span style="color: black;">便是</span>COOH与NH2键和反应），除此之外，最经典和被证明实用好用的办法<span style="color: black;">便是</span>SH跟Mal(马来酰亚胺)反应。其机理如下：</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="//q8.itc.cn/images01/20240729/2cdae9dde4814f948094c54fe0b116af.jpeg" style="width: 50%; margin-bottom: 20px;"><span style="color: black;">楚肽生物<span style="color: black;">供给</span></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">经过</span>SH（巯基）跟Mal (马来酰亚胺)加成反应，从而实现将带有SH的RGD多肽键和到带有Mal（马来酰）亚胺的纳米材料<span style="color: black;">或</span>其他材料上。<span style="color: black;">日前</span><span style="color: black;">咱们</span>可用于SH巯基键和的RGD环肽，<span style="color: black;">重点</span>有五种。分别是：</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">1. cyclo(RGDfC),其结构如下</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="//q7.itc.cn/images01/20240729/b3b7da724834476e895cb44979f22362.jpeg" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2. cyclo(RGDyC),其结构如下：</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="//q6.itc.cn/images01/20240729/4191162858c4455f8b5f7ba9a0731a81.jpeg" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">3. cyclo(RGDfK(Mpa),其结构如下：</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="//q4.itc.cn/images01/20240729/9431b768b9614f1295d88189972c8788.jpeg" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">经过</span>巯基丙酸，将SH延伸出来。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">4. cyclo(RGDfK(COCH2SH)其结构如下：</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="//q8.itc.cn/images01/20240729/82acba5844094fedbe75dffc8ab7caf7.jpeg" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">经过</span>巯基乙酸，将SH延伸出来。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">5. cyclo(RGDfK(Cys)) 其结构如下：</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="//q3.itc.cn/images01/20240729/3825fd3ded084812917c4181db2d156a.jpeg" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">经过</span>Cys(半胱氨酸），将SH延伸出来</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">综合比较，环肽cyclo（RGDfC）与环肽cyclo(RGDyC)本质没多大区别，cyclo(RGDfK(MPA)，cyclo(RGDfK(COCH2SH), cyclo(RGDfK(Cys) <span style="color: black;">亦</span>是类似。效果上，<span style="color: black;">由于</span>环肽cyclo（RGDfC）和环肽cyclo(RGDyC)中的巯基太靠近母核（RGD环肽），其SH跟Mal遇到<span style="color: black;">必定</span>的困难，<span style="color: black;">都数</span>客户<span style="color: black;">不可</span>很好的将两种环肽中的SH键和到Mal上，虽然文献有<span style="color: black;">非常多</span>报到<span style="color: black;">能够</span>，<span style="color: black;">实质</span>做起来有<span style="color: black;">必定</span>的困难。<span style="color: black;">因此</span>大部分的客户<span style="color: black;">选取</span>的是cyclo(RGDfK(Mpa)，这种将SH<span style="color: black;">经过</span>丙酸<span style="color: black;">或</span>乙酸延长的办法，有效的将SH巯基跟母核间隔开，让SH巯基能伸展出来。便于更好的与Mal加成反应<a style="color: black;"><span style="color: black;">返回<span style="color: black;">外链论坛：www.fok120.com</span>，查看<span style="color: black;">更加多</span></span></a></p>
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