重大突破:华裔专家发掘癌症新疗法
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">好<span style="color: black;">信息</span>,两位华裔专家在癌症<span style="color: black;">科研</span>上取得了重大突破!</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">近期</span>,美国华裔专家陈俊玮(Chun-Wei Chen)带领的团队<span style="color: black;">发掘</span>,两种细胞表面蛋白<span style="color: black;">一起</span>刺激癌细胞生长,<span style="color: black;">倘若</span>破坏它们之间的相互<span style="color: black;">功效</span>,就<span style="color: black;">能够</span>有效阻止癌细胞生长。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">这项突破性的<span style="color: black;">开发</span>成果,对癌症治疗<span style="color: black;">能够</span>说是<span style="color: black;">拥有</span>里程碑式的<span style="color: black;">道理</span>!</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">此前,美国华裔癌症专家凯瑟琳·吴(Catherine Wu)<span style="color: black;">由于</span>在癌症疫苗<span style="color: black;">科研</span>方面做出了“决定性贡献”,今年2月中旬<span style="color: black;">亦</span><span style="color: black;">得到</span>了瑞典皇家科学院颁发的舍伯格奖。</span></span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">据CNN<span style="color: black;">报告</span>,她的<span style="color: black;">科研</span>团队在“个性化抗癌疫苗”<span style="color: black;">行业</span>取得了最新<span style="color: black;">发展</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">有效阻止癌细胞生长 </strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">传统的癌症治疗<span style="color: black;">办法</span>,<span style="color: black;">一般</span>会在杀死癌细胞的<span style="color: black;">同期</span>,为人体带来巨大的副<span style="color: black;">功效</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">美国著名癌症<span style="color: black;">科研</span>与治疗机构<span style="color: black;">期盼</span>之城(City of Hope)此次则是另辟蹊径,为挽救<span style="color: black;">更加多</span>癌症<span style="color: black;">病人</span>的生命,带来新的曙光。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">据世界日报<span style="color: black;">报告</span>,华裔<span style="color: black;">专家</span>、<span style="color: black;">期盼</span>之城系统生物学华裔副教授陈俊玮带领的团队,经过数年<span style="color: black;">奋斗</span>,<span style="color: black;">发掘</span>了一种新的细胞机制。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="//q3.itc.cn/q_70/images03/20240227/99879ecbd1de46038cdfda2c9be23b8b.jpeg" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">陈俊玮团队<span style="color: black;">发掘</span>,两种细胞表面蛋白整合素αV和β5,<span style="color: black;">一起</span>刺激癌细胞生长。<span style="color: black;">专家</span>们认为,<span style="color: black;">倘若</span>能成功破坏αV和β5的相互<span style="color: black;">功效</span>,就<span style="color: black;">能够</span>阻止癌细胞生长。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">专家</span>们在进一步的<span style="color: black;">科研</span>中确定,<span style="color: black;">掌控</span>αV和β5两种蛋白质之间相互<span style="color: black;">功效</span>的,是β-螺旋桨结构域。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">在取得<span style="color: black;">重要</span>性突破后,陈俊玮团队进行了<span style="color: black;">海量</span>实验室实验,<span style="color: black;">同期</span>与电脑模拟相结合,<span style="color: black;">发掘</span>了精确靶向β-螺旋桨结构域的潜在癌症<span style="color: black;">药品</span>Cpd_AV2。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">研究</span>团队随后在实验室中将Cpd_AV2应用于人类癌细胞,结果<span style="color: black;">发掘</span>整合素αV和β5<span style="color: black;">快速</span>分离,这两种蛋白质之间的通信被破坏,从而有效阻止癌细胞生长,<span style="color: black;">引起</span>癌细胞死亡。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">临床上,<span style="color: black;">科研</span>人员<span style="color: black;">发掘</span>整合素αV在多种癌症类型中表现<span style="color: black;">明显</span>,在癌症的发展中起到主导<span style="color: black;">功效</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">数据<span style="color: black;">表示</span>,3700名乳腺癌、胰腺癌、肝癌、肺癌和脑癌<span style="color: black;">病人</span>中,高水平的整合素αV与不良预后<span style="color: black;">亦</span><span style="color: black;">关联</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">经过</span>扩大<span style="color: black;">研发</span>切断整合素αV和β5之间联系的标靶疗法机会,陈俊玮的突破性<span style="color: black;">研究</span>成果,为癌症治疗和<span style="color: black;">药品</span><span style="color: black;">开发</span><span style="color: black;">供给</span>有效的新<span style="color: black;">办法</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">陈俊玮指出,这项<span style="color: black;">科研</span>成果揭示了蛋白质上<span style="color: black;">拥有</span>致癌能力的位点,这些位点此前从未被<span style="color: black;">发掘</span>,为下一代肿瘤治疗的进步开辟了新的途径,</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">这项<span style="color: black;">科研</span><span style="color: black;">亦</span>是<span style="color: black;">期盼</span>之城对抗癌症的<span style="color: black;">要紧</span>里程碑,<span style="color: black;">针对</span>未来全新治癌<span style="color: black;">药品</span>的<span style="color: black;">研发</span>,有着前瞻性的<span style="color: black;">道理</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="//q4.itc.cn/q_70/images03/20240227/833631e3e57f4f8f810b66ac86aeeee3.jpeg" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">陈俊玮强调,Cpd_AV2化合物<span style="color: black;">日前</span>还不是真正的治癌<span style="color: black;">药品</span>,离最后走向市场的<span style="color: black;">药品</span>还有一段距离。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">近期,陈俊玮的<span style="color: black;">研究</span>成果<span style="color: black;">最终</span>在权威的《自然结构与分子生物学》(Nature Structural & Molecular Biology)杂志上<span style="color: black;">发布</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">陈俊玮还<span style="color: black;">尤其</span><span style="color: black;">说到</span>,自己的团队中华裔<span style="color: black;">专家</span>占到一半。自2019年<span style="color: black;">起始</span>,在长达4年多的时间里,十几名团队成员夜以继日地投入到这项科学<span style="color: black;">科研</span>工作中,<span style="color: black;">最终</span><span style="color: black;">得到</span>重大收获。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">陈俊玮<span style="color: black;">暗示</span>,“华裔<span style="color: black;">专家</span>在顶尖科学<span style="color: black;">科研</span>中的<span style="color: black;">功效</span><span style="color: black;">已然</span>越来越<span style="color: black;">要紧</span>。”</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">华裔女博士为抗癌疫苗做出决定性贡献</strong></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">凯瑟琳·吴<span style="color: black;">亦</span>是这些杰出华裔中的一员,她是美国波士顿达纳法伯癌症研究所的肿瘤学家。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">凯瑟琳·吴针对个体肿瘤基因组的不同<span style="color: black;">状况</span><span style="color: black;">研发</span>了癌症疫苗,在临床<span style="color: black;">实验</span>中产生了前所未有的<span style="color: black;">守护</span>水平。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">每一个</span>人的癌症在基因上都是独一<span style="color: black;">没</span>二的,吴博士和她的团队<span style="color: black;">发掘</span>了<span style="color: black;">怎样</span>识别这些突变并利用身体来对抗它们。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="//q6.itc.cn/q_70/images03/20240227/fd66083e4db842169413bcfe71288134.jpeg" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">初步<span style="color: black;">实验</span>结果<span style="color: black;">表示</span>,这种策略对治疗黑色素瘤和胰腺癌等难治性癌症有着越来越大的<span style="color: black;">期盼</span>,并且<span style="color: black;">最后</span>可能适用于200多种癌症类型。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">舍伯格奖的授奖委员会秘书长、瑞典卡罗林斯卡学院的遗传学教授伦达尔(Urban Lendahl) <span style="color: black;">暗示</span>,尽管<span style="color: black;">数年</span>来癌症治疗取得了<span style="color: black;">有些</span><span style="color: black;">发展</span>,但许多癌症形式的医疗需求仍未得到满足。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">吴博士的<span style="color: black;">科研</span><span style="color: black;">经过</span><span style="color: black;">运用</span>数千种潜在的新抗原候选物,并<span style="color: black;">经过</span>杰出的实验技术识别出细胞表面的新抗原,使它们有可能成为癌症疫苗。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">该奖项金额为个人<span style="color: black;">供给</span>100,000美元的奖金,并<span style="color: black;">供给</span>900,000美元<span style="color: black;">做为</span>继续<span style="color: black;">科研</span>的资金。2024年舍伯格奖将于4 月12日在学院年会上由国王卡尔十六世·古斯塔夫颁发。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">日前</span>,吴博士的团队和其他医学<span style="color: black;">科研</span>小组正在与默克、莫德纳和BioNTech等制药<span style="color: black;">机构</span>合作,<span style="color: black;">研发</span>治疗胰腺癌、肺癌和黑色素瘤的疫苗,并正在进行<span style="color: black;">实验</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="//q7.itc.cn/q_70/images03/20240227/333ff9c385de462c9438d8e239a65dc1.jpeg" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">不外</span>,<span style="color: black;">日前</span>进行的所有<span style="color: black;">实验</span>都是小规模的,<span style="color: black;">一般</span><span style="color: black;">触及</span><span style="color: black;">少许</span>晚期<span style="color: black;">疾患</span><span style="color: black;">病人</span>,并<span style="color: black;">拥有</span>较高的安全<span style="color: black;">危害</span>承受能力。要证明这种类型的癌症疫苗有效,<span style="color: black;">必须</span>进行更大规模的随机对照<span style="color: black;">实验</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">吴博士说,<span style="color: black;">怎样</span>使这种<span style="color: black;">办法</span>发挥最佳效果<span style="color: black;">必须</span>投资。<span style="color: black;">怎样</span>以更具性价比的方式生产疫苗,从而使<span style="color: black;">更加多</span>的癌症<span style="color: black;">病人</span>受益,<span style="color: black;">亦</span>是一个巨大的挑战。</p>
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