重大突破!不化疗不放疗不手术 14名癌症病人参与新药实验所有治愈
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">重大突破!不化疗不放疗不手术 14名癌症<span style="color: black;">病人</span>参与新药<span style="color: black;">实验</span><span style="color: black;">所有</span>治愈</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><a style="color: black;">每日经济<span style="color: black;">资讯</span></a></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><a style="color: black;">2022年06月09日 15:07:51 来自四川</a>
</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">人类再次在对抗癌症的道路上迈出有巨大<span style="color: black;">道理</span>的一步!</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">6月5日,一项<span style="color: black;">发布</span>在《新英格兰医学杂志》上的<span style="color: black;">科研</span>结果<span style="color: black;">表示</span>,美国纪念斯隆-凯特林癌症<span style="color: black;">科研</span>所(MSK)进行的一项小型临床<span style="color: black;">实验</span><span style="color: black;">发掘</span>,制药<span style="color: black;">机构</span>葛兰素史克一款名为多塔利单抗(dostarlimab)的免疫治疗<span style="color: black;">药品</span>,让直肠癌<span style="color: black;">病人</span><span style="color: black;">所有</span>痊愈。</p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://pic4.zhimg.com/80/v2-3c23187c21623e2c9ef9fe8ea60cb9df_720w.webp" style="width: 50%; margin-bottom: 20px;"></div>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">这篇论文摘要<span style="color: black;">表示</span>,在一项小型2期临床<span style="color: black;">实验</span>中,12名直肠癌<span style="color: black;">病人</span>在接受了一款创新免疫疗法后,<span style="color: black;">她们</span><span style="color: black;">身体</span>的肿瘤都消失了,<span style="color: black;">无</span><span style="color: black;">病人</span><span style="color: black;">必须</span>进行后续化疗、放疗或手术,在随访<span style="color: black;">时期</span><span style="color: black;">无</span>观察到<span style="color: black;">疾患</span>复发(中位随访时间1年,最长达25个月),并且<span style="color: black;">无</span>一名<span style="color: black;">病人</span>报告3级或以上不良反应。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">实验</span>结果<span style="color: black;">发布</span>在6月5日的《新英格兰医学杂志》上。在2022年美国临床肿瘤学会年会上,该团队报告了更新结果,展示了总共14名完全缓解的<span style="color: black;">病人</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">14名<span style="color: black;">病人</span>临床完全缓解的比例为100%</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">据科技日报,<span style="color: black;">病人</span>接受了葛兰素史克<span style="color: black;">机构</span>研制的一种免疫治疗<span style="color: black;">药品</span>dostarlimab的治疗。<span style="color: black;">科研</span>人员说,每位<span style="color: black;">病人</span>的癌症都神奇地消失了,体检、内窥镜<span style="color: black;">检测</span>、PET扫描或MRI扫描<span style="color: black;">没</span>法检测到癌症。</p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://pic1.zhimg.com/80/v2-5a35ba03d54a96c361eb8fd64df934b8_720w.webp" style="width: 50%; margin-bottom: 20px;"></div>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">这项单臂II期<span style="color: black;">科研</span><span style="color: black;">最后</span>将招募30名临床II期和III期dMMR直肠癌<span style="color: black;">病人</span>。在迄今为止的18名<span style="color: black;">病人</span>中,除一名<span style="color: black;">病人</span>外,所有<span style="color: black;">病人</span>都是淋巴结阳性,大约一半<span style="color: black;">身患</span>林奇<span style="color: black;">综合症</span>。大<span style="color: black;">都数</span> (78%) <span style="color: black;">身患</span>T3或T4直肠肿瘤。所有<span style="color: black;">病人</span>都是dMMR和BRAF V600E野生型肿瘤,值得一提的是,这些<span style="color: black;">病人</span>中的大<span style="color: black;">都数</span>都有大块肿瘤。<span style="color: black;">另一</span>,所有<span style="color: black;">病人</span>尚未接受放化疗。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">这些<span style="color: black;">病人</span><span style="color: black;">每日</span>接受500mg dostarlimab,<span style="color: black;">连续</span>6个月后随访。之后每4个月对临床完全缓解的<span style="color: black;">病人</span>进行非手术随访;<span style="color: black;">针对</span>有残留病灶的<span style="color: black;">病人</span>接受放化疗。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">论文摘要<span style="color: black;">表示</span>,在已完成6个月治疗的14名<span style="color: black;">病人</span>中,临床完全缓解的百分比为100%,在12个月的中位随访<span style="color: black;">时期</span>,<span style="color: black;">无</span><span style="color: black;">病人</span>接受过放化疗,<span style="color: black;">亦</span><span style="color: black;">无</span><span style="color: black;">病人</span>接受过手术切除,<span style="color: black;">无</span><span style="color: black;">病人</span><span style="color: black;">显现</span><span style="color: black;">疾患</span>恶化或复发。在dostarlimab治疗6个月后临床完全缓解且组织可<span style="color: black;">评定</span>的<span style="color: black;">病人</span>在内镜活检中<span style="color: black;">亦</span><span style="color: black;">无</span>肿瘤组织学证据。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">据科技日报援引英国《泰晤士报》<span style="color: black;">报告</span>,该<span style="color: black;">药品</span>每剂成本约为11000美元(约合人民币7.3万元)。每3周给<span style="color: black;">病人</span><span style="color: black;">吃下</span>一次,<span style="color: black;">连续</span>6个月。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">科研</span>人员一致认为,这项<span style="color: black;">实验</span><span style="color: black;">此刻</span><span style="color: black;">必须</span>在一项更大的<span style="color: black;">科研</span>中复制,并指出这项小型<span style="color: black;">科研</span>只关注肿瘤中<span style="color: black;">拥有</span>罕见遗传特征的<span style="color: black;">病人</span>。但<span style="color: black;">她们</span>说,在100%的受试<span style="color: black;">病人</span>中看到完全缓解是一个非常有<span style="color: black;">期盼</span>的<span style="color: black;">初期</span>信号。</p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://pic3.zhimg.com/80/v2-f630f5cce0b8a46b57941b33e5ad3732_720w.webp" style="width: 50%; margin-bottom: 20px;"></div>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">(图为四名<span style="color: black;">病人</span>和两名<span style="color: black;">实验</span><span style="color: black;">科研</span>人员。图源:纪念斯隆凯特琳癌症中心官网)</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">科研</span>人员说,人体的免疫细胞<span style="color: black;">包括</span>一种<span style="color: black;">叫作</span>为<span style="color: black;">检测</span>点的<span style="color: black;">守护</span><span style="color: black;">办法</span>,以防止它们攻击正常细胞。<span style="color: black;">然则</span>癌细胞<span style="color: black;">能够</span>影响这种<span style="color: black;">守护</span>并关闭免疫细胞,从而使肿瘤得以<span style="color: black;">隐匿</span>和生长。这种新疗法是一种免疫疗法,<span style="color: black;">经过</span>阻断癌细胞“不要吃我”信号,使免疫系统能够消除它们。该治疗<span style="color: black;">办法</span>针对的是DNA修复系统不起<span style="color: black;">功效</span>的直肠癌亚型。当修复系统不起<span style="color: black;">功效</span>时,蛋白质中会产生<span style="color: black;">更加多</span>错误,免疫系统会识别这些错误并杀死癌细胞。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">科研</span>人员<span style="color: black;">暗示</span>,结果令人惊讶,临床<span style="color: black;">实验</span>中的<span style="color: black;">每一个</span><span style="color: black;">病人</span>都对一种<span style="color: black;">药品</span>有反应,几乎是闻所未闻的。<span style="color: black;">科研</span>人员为这种单独<span style="color: black;">运用</span>免疫疗法靶向特定肿瘤的<span style="color: black;">办法</span>创造了一个术语 “免疫消融”,<span style="color: black;">寓意</span>着<span style="color: black;">运用</span>“免疫疗法代替手术、化疗和放疗来消除癌症”。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">科研</span>人员<span style="color: black;">叫作</span>,直肠癌手术和放疗对生育能力、性健康、肠道和膀胱功能有永久性的影响,对生活质量的影响巨大,<span style="color: black;">尤其</span>是<span style="color: black;">哪些</span>经标准治疗会影响生育<span style="color: black;">潜能</span>的人。随着<span style="color: black;">青年</span>人直肠癌发病率的<span style="color: black;">提升</span>,新<span style="color: black;">办法</span>可能会产生重大影响。</p>论文指出,尽管仍需更<span style="color: black;">长期</span>的随访来确定疗效持久性,<span style="color: black;">亦</span>需要在更大规模<span style="color: black;">科研</span>中进行验证,这些数据为<span style="color: black;">经过</span>新辅助治疗<span style="color: black;">有效</span>抗癌<span style="color: black;">供给</span>了借鉴——将<span style="color: black;">精细</span>医学应用于<span style="color: black;">初期</span>癌症,在最可能<span style="color: black;">生效</span>时进行治疗,以<span style="color: black;">帮忙</span><span style="color: black;">病人</span>免于放化疗和手术。“这可能为多种类型肿瘤的免疫清除(immunoablative)<span style="color: black;">办法</span>开启<span style="color: black;">前门</span>”。
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">83%的结直肠癌<span style="color: black;">病人</span>一<span style="color: black;">发掘</span><span style="color: black;">便是</span>中晚期</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">据中国青年报<span style="color: black;">报告</span>,中国抗癌协会肿瘤防治科普专业委员会<span style="color: black;">经过</span>官方<span style="color: black;">博客</span><span style="color: black;">颁布</span>科普<span style="color: black;">叫作</span>,83%的结直肠癌<span style="color: black;">病人</span>一经<span style="color: black;">发掘</span><span style="color: black;">便是</span>中晚期,而结直肠癌却是最“笨”的癌,在癌前病变<span style="color: black;">周期</span><span style="color: black;">发掘</span>,<span style="color: black;">一般</span>肠镜微创手术就<span style="color: black;">能够</span>治愈,阻断癌症的<span style="color: black;">出现</span>。<span style="color: black;">同期</span><span style="color: black;">举荐</span>“筛查漏斗”,遵循《中国肿瘤整合诊治指南(CACA)》2022的<span style="color: black;">举荐</span>,<span style="color: black;">运用</span>免疫法粪便隐血<span style="color: black;">实验</span>(FIT)、多靶点粪便 FIT-DNA 检测、结肠镜三种筛查手段就可实现肠癌及癌前病变的早<span style="color: black;">发掘</span>、早诊断、早治疗。</p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://pic3.zhimg.com/80/v2-fa7de53ced4a696e0b4ef459943ca2f2_720w.webp" style="width: 50%; margin-bottom: 20px;"></div>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">据<span style="color: black;">认识</span>,肠癌是基因病,是遗传性最强的高发癌症。《中国结直肠癌筛查与早诊早治指南(2020,北京)》指出,若父母、兄弟姐妹及其子女(一级亲属)有肠癌史,则其发病<span style="color: black;">危害</span>是普通人群的1.76倍;一级亲属患结直肠癌的女性发病<span style="color: black;">危害</span>是普通人群<span style="color: black;">危害</span>的2.07倍。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">遗传<span style="color: black;">引起</span>的结直肠癌触目惊心,但<span style="color: black;">无</span>家族史的并不<span style="color: black;">表率</span><span style="color: black;">无</span><span style="color: black;">危害</span>。2020年,我国新发肿瘤<span style="color: black;">病人</span>457万,其中家族遗传性肿瘤占5%~10%。<span style="color: black;">寓意</span>着90%以上的肿瘤<span style="color: black;">病人</span>,并<span style="color: black;">无</span>直系亲属患癌。</p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://pic3.zhimg.com/80/v2-070fd28f20093a7d66e194632ac1ebfa_720w.webp" style="width: 50%; margin-bottom: 20px;"></div>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">照片</span><span style="color: black;">源自</span>:摄图网-ID:400909202</p>在今年全国肿瘤防治宣传周<span style="color: black;">时期</span>,中国医学科学院肿瘤医院胰胃外科病区<span style="color: black;">专家</span>田艳涛教授在《防癌的真相》科普讲座中指出,肿瘤是内因和外因<span style="color: black;">一起</span><span style="color: black;">功效</span>下产生的<span style="color: black;">疾患</span>。90%以上的肿瘤<span style="color: black;">病人</span>是<span style="color: black;">因为</span>后天<span style="color: black;">膳食</span>起居等生活习惯不良,及<span style="color: black;">心情</span>管理<span style="color: black;">欠好</span>等<span style="color: black;">原由</span>而致病。
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">据世卫组织<span style="color: black;">颁布</span>的数据<span style="color: black;">表示</span>,2020年, 结直肠癌已<span style="color: black;">提升</span>为中国排名第二的高发癌症,新发病例在中国高发癌症中增长最快,死亡率为9.5%。基于2020年癌症死亡人数来算,<span style="color: black;">每日</span>有780余人<span style="color: black;">因此呢</span>去世, 相当于每小时32人,基于新发病例来算,每日新增1500余人 。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">美国<span style="color: black;">疾患</span><span style="color: black;">掌控</span>预防中心(CDC)和美国<span style="color: black;">疾患</span>预防工作组(USPSTF)认为,<span style="color: black;">日前</span><span style="color: black;">仅有</span>四种癌症<span style="color: black;">能够</span>有效筛查并且<span style="color: black;">持有</span>筛查指南,结直肠癌是其中之一 ,且被<span style="color: black;">举荐</span>为A级适合早筛的癌种。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">我国和美国的结直肠癌防治经验均<span style="color: black;">显示</span>,<span style="color: black;">经过</span>筛查<span style="color: black;">发掘</span>癌前病变并<span style="color: black;">干涉</span><span style="color: black;">能够</span>降低肠癌的死亡率和发病率。<span style="color: black;">针对</span>个人来讲,越早<span style="color: black;">发掘</span>治愈率越高。<span style="color: black;">倘若</span>能够有效<span style="color: black;">发掘</span>癌前病变并<span style="color: black;">干涉</span>,则能够预防肠癌。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">编辑| 孙志成 杜恒峰 杜波</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">校对|程鹏</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">“<span style="color: black;">尤其</span>声明:以上作品内容(<span style="color: black;">包含</span>在内的视频、<span style="color: black;">照片</span>或音频)为凤凰网旗下自<span style="color: black;">媒介</span>平台“大风号”用户上传并<span style="color: black;">颁布</span>,本平台仅<span style="color: black;">供给</span>信息存储空间服务。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">Notice: The content above (including the videos, pictures and audios if any) is uploaded and posted by the user of Dafeng Hao, which is a social media platform and merely provides information storage space services.”</p>[<span style="color: black;">责任编辑:网友投稿</span>于雷 PT032]
谷歌外贸网站优化技术。 交流如星光璀璨,点亮思想夜空。 楼主听话,多发外链好处多,快到碗里来!外链论坛 http://www.fok120.com/
页:
[1]