近期专家们在癌症复发科研行业取得的新发展!
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">复发<span style="color: black;">始终</span>是<span style="color: black;">专家</span>们在癌症<span style="color: black;">科研</span><span style="color: black;">行业</span>所面临的巨大挑战,近年来<span style="color: black;">专家</span>们投入了<span style="color: black;">海量</span>精力来阐明多种癌症复发<span style="color: black;">暗地里</span>的机制,本文中,<span style="color: black;">博主</span>整理了近期<span style="color: black;">专家</span>们在癌症复发<span style="color: black;">科研</span><span style="color: black;">行业</span>取得的新<span style="color: black;">发展</span>,与<span style="color: black;">大众</span><span style="color: black;">一块</span>学习!</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">【1】MSB:代谢记忆或在乳腺癌复发过程中扮演着<span style="color: black;">重要</span>角色</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">doi:10.15252/msb.202010141</p>
<div style="color: black; text-align: left; margin-bottom: 10px;"><img src="https://pic3.zhimg.com/80/v2-f3a1f8a633be8fd8555d66ab22ea3fc6_720w.webp" style="width: 50%; margin-bottom: 20px;"></div>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">代谢记忆或在乳腺癌复发过程中扮演着<span style="color: black;">重要</span>角色。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">照片</span><span style="color: black;">源自</span>:DOI:10.15252/msb.202010141</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">大<span style="color: black;">都数</span>与乳腺癌<span style="color: black;">关联</span>的死亡都<span style="color: black;">是由于</span>对疗法耐受细胞(最小的残留性<span style="color: black;">疾患</span>,MRD)<span style="color: black;">导致</span>的肿瘤复发所<span style="color: black;">引起</span>的,然而,定义其恶性程度的分子特征在很大程度上<span style="color: black;">科研</span>人员并不清楚。<span style="color: black;">近期</span>,一篇<span style="color: black;">发布</span>在国际杂志Molecular Systems Biology上题为“Metabolic memory underlying minimal residual disease in breast cancer”的<span style="color: black;">科研</span>报告中,来自欧洲分子生物学实验室等<span style="color: black;">公司</span>的<span style="color: black;">专家</span>们<span style="color: black;">经过</span>分析对原有疗法耐受的肿瘤细胞,识别出了能有效预防乳腺癌复发的疗法的分子靶点。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">近期</span>在<span style="color: black;">初期</span>检测和靶向性疗法<span style="color: black;">研发</span>上的<span style="color: black;">科研</span><span style="color: black;">发展</span>使得<span style="color: black;">专家</span>们成功治疗乳腺癌的机会越来越多,中<span style="color: black;">一般</span>是<span style="color: black;">经过</span>沉默驱动肿瘤的爱因并<span style="color: black;">诱发</span>肿瘤消退来实现的;然而,在初次治疗后有一小部分的肿瘤细胞会存活下来,这或许会让<span style="color: black;">科研</span>人员面临着巨大挑战,<span style="color: black;">由于</span>这类细胞会<span style="color: black;">引起</span>20%-40%的<span style="color: black;">病人</span>在几年<span style="color: black;">乃至</span>几十年后<span style="color: black;">显现</span><span style="color: black;">疾患</span>复发,<span style="color: black;">况且</span>会非常难以治疗。这篇<span style="color: black;">科研</span>报告中,<span style="color: black;">科研</span>人员所得到的<span style="color: black;">科研</span>结果或有望<span style="color: black;">帮忙</span><span style="color: black;">研发</span>出有效预防乳腺癌复发并改善<span style="color: black;">病人</span>生活质量的新型疗法。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">癌基因表达水平的生长与多种癌症<span style="color: black;">出现</span>直接<span style="color: black;">关联</span>,这<span style="color: black;">是由于</span>其突变或对其表达的<span style="color: black;">掌控</span>过程<span style="color: black;">出现</span>改变<span style="color: black;">导致</span>;在肿瘤<span style="color: black;">出现</span>过程中参与癌基因表达水平<span style="color: black;">上升</span>的<span style="color: black;">重点</span>过程之一<span style="color: black;">便是</span>DNA甲基化水平的改变,即甲基基团附着到DNA上会<span style="color: black;">引起</span><span style="color: black;">基本</span>基因表达<span style="color: black;">出现</span>改变;<span style="color: black;">科研</span>人员对在初始疗法中存活的一小部分细胞(MRD)进行甲基化的改变分析,MRD能在相当长的休眠期后进行增殖,并<span style="color: black;">诱发</span>癌症<span style="color: black;">出现</span>不可治愈的复发。<span style="color: black;">经过</span>在乳腺癌小鼠模型中应用先进的数据集中化技术并整合不同水平的细胞<span style="color: black;">行径</span>,<span style="color: black;">科研</span>人员就能将MRD细胞的代谢和甲基化水平与原始肿瘤细胞和正常健康细胞的相同过程进行对比。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">原始出处:</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">Ksenija Radic Shechter,Eleni Kafkia,Katharina Zirngibl, et al. Metabolic memory underlying minimal residual disease in breast cancer, Molecular Systems Biology (2021). DOI:10.15252/msb.202010141</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">【2】Cancer Cell:<span style="color: black;">经过</span>检测样本中的游离DNA来指示小儿髓母细胞瘤复发的迹象</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">doi:10.1016/j.ccell.2021.09.012</p>
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