l14107cb 发表于 2024-5-25 07:54:23

“第五种癌症治疗办法”的光免疫疗法,功效机制是什么?(下)

<img src="https://mmbiz.qpic.cn/mmbiz_png/WpnEBziaB4SOibgGmBMp5CTLDgNe2iaM7O5bkol2tpO2dJf1o7ibMh3SficXNgXAtLQUicTlt4C7dbjouD00M9zZjK1A/640?wx_fmt=png&amp;tp=webp&amp;wxfrom=5&amp;wx_lazy=1&amp;wx_co=1" style="width: 50%; margin-bottom: 20px;">
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">光免疫疗法,<span style="color: black;">做为</span>继手术、放疗、化疗、靶向免疫<span style="color: black;">药品</span>之后的“第五种癌症疗法”,正在备受关注。<span style="color: black;">日前</span>,日本多家医院已面向<span style="color: black;">有些</span>癌症<span style="color: black;">病人</span><span style="color: black;">起始</span>采用这种疗法,对此医疗人员和<span style="color: black;">病人</span>都高度期待。</span></p>
    <h1 style="color: black; text-align: left; margin-bottom: 10px;"><a style="color: black;"><strong style="color: blue;"><span style="color: black;">“第五种癌症治疗<span style="color: black;">办法</span>”的光免疫疗法,到底是什么?</span></strong></a></h1>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">上一篇,繫康万家向<span style="color: black;">大众</span>进一步<span style="color: black;">仔细</span>介绍“光免疫疗法”的治疗机制,<span style="color: black;">期盼</span>能够<span style="color: black;">帮忙</span><span style="color: black;">大众</span>更加深入<span style="color: black;">认识</span>这项抗癌“黑科技”。</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">光免疫治疗机制</strong></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">功效</span>机制</strong></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">如下图所述,光免疫治疗<span style="color: black;">经过</span>自由基反应*1杀伤肿瘤细胞</span><span style="color: black;">,产生<span style="color: black;">拥有</span>肿瘤毒性的单项氧反应<span style="color: black;">*2</span>,诱导肿瘤坏死和细胞凋亡。</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;"><span style="color: black;">*1</span>自由基反应:酸性自由基与氧反应产生<span style="color: black;">各样</span>氧化物质</span></strong></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">→杀死肿瘤细胞效应</span></strong></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;"><span style="color: black;">*2</span>单项氧反应:被激发的光感受性物质将肿瘤组织内的氧置换为单项氧</span></strong></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">→促使肿瘤坏死/细胞凋亡</span></strong></p><img src="https://mmbiz.qpic.cn/mmbiz_png/85G2eIGAf5yw2TpQ6ia99ewibnJgazDllsfyQibEjqlkyMgUQm9oiaCDBXVUhBjTQuFJgboSk8HrzebxBJibynAxB1g/640?wx_fmt=png&amp;tp=webp&amp;wxfrom=5&amp;wx_lazy=1&amp;wx_co=1" style="width: 50%; margin-bottom: 20px;">
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">PDT和PTT都<span style="color: black;">是由于</span>光激发的光敏剂,<span style="color: black;">经过</span>生成活性氧和热对癌细胞<span style="color: black;">导致</span><span style="color: black;">损害</span>。</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">(<span style="color: black;">源自</span>:Li,X.、Lovell、JF、Yoon、J.针对其他癌症的光热和光学动力疗法的临床<span style="color: black;">研发</span>和<span style="color: black;">潜能</span>。Nat Rev Clin Oncol 17, 657-674(2020)。摘自部分改编)</span></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">光敏物质(增敏剂)聚集肿瘤的机制</span></strong></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">因为</span>下列①②的<span style="color: black;">原由</span>,肿瘤组织中有比正常组织<span style="color: black;">更易</span>聚集光感受性物质的性质。</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;">•①血管通透性<span style="color: black;">显著</span>亢进</strong></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;">→高分子和微粒子比血管<span style="color: black;">更易</span>流出</strong></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;">•②淋巴系统不发达</strong></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;">→到达肿瘤组织的物质很难排泄</strong></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">利用<span style="color: black;">这般</span>的特性使高分子和微粒子聚集在癌细胞上的现象被<span style="color: black;">叫作</span>为EPR效应。EPR效果是从量、空间、时间上<span style="color: black;">掌控</span><span style="color: black;">身体</span><span style="color: black;">药品</span>分布,是<span style="color: black;">药品</span>传递系统DDS<span style="color: black;">(<span style="color: black;">药品</span>递送系统)</span>的一种,活用DDS另一种视角的混合脂质体是本治疗的强项。有<span style="color: black;">科研</span><span style="color: black;">叫作</span>,混合脂质体不仅对癌细胞膜<span style="color: black;">拥有</span>特异性的融合、<span style="color: black;">累积</span>性,其本身还<span style="color: black;">拥有</span>对癌细胞的<span style="color: black;">损伤</span>性。</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">(参考文献:市原英明,永见英明,山本圭一,松本阳子,上冈龙一,生物<span style="color: black;">身体</span>不<span style="color: black;">运用</span>药剂的混合脂质体的化学疗法,药学杂志2003年123卷1号p.25-34)</span></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">什么是EPR效应</strong></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;"><span style="color: black;">所说</span>EPR效应,<span style="color: black;">便是</span>活用癌细胞<span style="color: black;">周边</span>组织的特有性质。癌细胞<span style="color: black;">周边</span>的血管是不完全的,<span style="color: black;">拥有</span>穿透性<span style="color: black;">(permeability)</span>,即使是正常血管<span style="color: black;">没</span>法<span style="color: black;">经过</span>的大分子(数百nm)<span style="color: black;">亦</span>能穿透血管渗透到组织中。<span style="color: black;">况且</span>,<span style="color: black;">因为</span>癌细胞<span style="color: black;">周边</span>的免疫机制不完整,<span style="color: black;">不可</span>正常清除异物,渗透的分子会保持(retention)在细胞内</span></strong></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">。</p>

    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">该现象的药理<span style="color: black;">功效</span><span style="color: black;">叫作</span>为EPR(Enhanced Permeability and Retention)效应,<span style="color: black;">通常</span><span style="color: black;">没</span>法渗透到组织中的高分子<span style="color: black;">药品</span>就能够到达癌组织。<span style="color: black;">由于</span>这种<span style="color: black;">行径</span>不会<span style="color: black;">出现</span>在正常细胞中,<span style="color: black;">因此</span>只能将大分子<span style="color: black;">药品</span>传递给癌细胞组织。这<span style="color: black;">亦</span>是DDS(<span style="color: black;">药物</span>传递系统)特别受关注的<span style="color: black;">原由</span>,该系统<span style="color: black;">能够</span>向癌细胞<span style="color: black;">周边</span><span style="color: black;">选取</span>性地传递<span style="color: black;">药物</span>。</span></p><img src="https://mmbiz.qpic.cn/mmbiz_png/85G2eIGAf5yw2TpQ6ia99ewibnJgazDllszOjmvMzr4pTuf7KoCmSPqia57VsUyxf0u5tPqEIykJdjDQsMyjHz4Xg/640?wx_fmt=png&amp;tp=webp&amp;wxfrom=5&amp;wx_lazy=1&amp;wx_co=1" style="width: 50%; margin-bottom: 20px;">
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">(<span style="color: black;">源自</span>: Enhanced Permeability and Retention (EPR) Effect Based Tumor Targeting:The Concept, Application and ProspectHongzhuan Yin, Long Liao, Jun Fang Published in 2014) Enhanced Permeability and Retention (EPR) Effect Based Tumor Targeting: The Concept, Application and ProspectHongzhuan Yin, Long Liao, Jun Fang Published in 2014)</p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">什么是混合脂质体</strong></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">光感受性物质或光敏剂是光免疫疗法中的<span style="color: black;">重要</span>,<span style="color: black;">做为</span>运送光敏剂的介质,<span style="color: black;">经过</span><span style="color: black;">运用</span>脂质体<span style="color: black;">做为</span>载体,光敏剂<span style="color: black;">能够</span>很好地进入癌组织。传统治疗中,不<span style="color: black;">运用</span>脂质体载体会<span style="color: black;">引起</span>增敏剂<span style="color: black;">不可</span>有效地使癌细胞聚集,癌细胞以外的正常组织<span style="color: black;">亦</span>会被迫吸收增敏剂,<span style="color: black;">显现</span>光线过敏的副<span style="color: black;">功效</span>。</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">另外</span>,<strong style="color: blue;"><span style="color: black;">经过</span>在脂质体中<span style="color: black;">选取</span>被<span style="color: black;">叫作</span>为混合脂质体的脂质体和michel(脂质凝聚体)的复合体,不仅<span style="color: black;">能够</span>发挥它<span style="color: black;">选取</span>性更高的载体<span style="color: black;">功效</span>,还能被赋予双重<span style="color: black;">控制</span>的<span style="color: black;">功效</span></strong>。</span></p><img src="https://mmbiz.qpic.cn/mmbiz_png/85G2eIGAf5yw2TpQ6ia99ewibnJgazDllsc6TwjuQ9gxjxiaQo5DhCY0Rmic16PzoNCMhclgkuDXquZwRHBlL0XEfA/640?wx_fmt=png&amp;tp=webp&amp;wxfrom=5&amp;wx_lazy=1&amp;wx_co=1" style="width: 50%; margin-bottom: 20px;">
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">• 混合脂质体:Vesicle≈liposome和Micelle的复合体。</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">• Vesicle:由磷脂双分子膜(两条碳氢链和脂质为基本结构)<span style="color: black;">构成</span>的封闭内质网</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">• Micelle:<span style="color: black;">拥有</span>一条碳氢化合物链的脂质凝聚体</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">(<span style="color: black;">源自</span>:上冈龙一,市原英明,古水雄志,混合脂质体的癌症治疗和分子机制,生物<span style="color: black;">理学</span>54 (1),005-010,2014)</span></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;">光免疫疗法</strong></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;">光疗仪器</strong></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">在光疗中<span style="color: black;">运用</span>的光治疗仪,<span style="color: black;">运用</span>适合于激发光感物质/增敏剂的波长600~1000nm的近红外光振荡器。</span></p><img src="https://mmbiz.qpic.cn/mmbiz_png/85G2eIGAf5yw2TpQ6ia99ewibnJgazDlls5p7jVpMzXA6Qicb3ZibNLeKEfhoSsSExvFrT8TpImCFFSIyRxuLpR6wA/640?wx_fmt=png&amp;tp=webp&amp;wxfrom=5&amp;wx_lazy=1&amp;wx_co=1" style="width: 50%; margin-bottom: 20px;">
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">光照法</span></strong></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">癌症的光照法<span style="color: black;">包含</span>从表面辐照、<span style="color: black;">运用</span>特殊的激光纤维直接穿刺照射肿瘤的间质辐照、内视镜照射等。</span></p><img src="https://mmbiz.qpic.cn/mmbiz_png/85G2eIGAf5yw2TpQ6ia99ewibnJgazDllsGFGxvvneLo5YXpjVxywXaLmdVCSYYicc4AaLkEcVNFDLDrasJcWhTyw/640?wx_fmt=png&amp;tp=webp&amp;wxfrom=5&amp;wx_lazy=1&amp;wx_co=1" style="width: 50%; margin-bottom: 20px;">
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">(<span style="color: black;">源自</span>:Clinical development and potential of photothermal and photodynamic therapies for cancer | Nature Reviews Clinical Oncology)</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">光敏物质(增敏剂)种类</span></strong></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">光敏剂:在光疗中<span style="color: black;">运用</span>的光敏剂(光感物质)分为以下几种:</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">•A 卟啉钠 &lt;最佳波长630nm&gt;</span></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">•B 塔拉卟啡 &lt;64nm&gt;</span></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">•C R-700(+抗EGFR抗体) &lt;700nm&gt;</span></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">•D 5ALA &lt;410nm&gt;</span></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">•E ICG(+脂质体) &lt;810nm&gt;</span></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">北青山D.CLINIC<span style="color: black;">供给</span><span style="color: black;">运用</span>ICG / 5ALA /(塔拉卟啉)光敏剂的治疗。</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">治疗适应</strong></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">可接受光免疫治疗的癌症类型如下:</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;">•可进行表面辐照的适应类型:</strong></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">头颈部癌/乳腺癌/体壁转移癌/体表淋巴结转移/骨转移<span style="color: black;">(<span style="color: black;">重点</span>动脉浸润者除外)</span></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;">•可进行激光纤维穿刺的适应类型:</strong></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">距离体壁几厘米,<span style="color: black;">能够</span>进行安全穿刺的癌症<span style="color: black;">(动脉、消化道等浸润者除外)</span></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;">•可<span style="color: black;">经过</span>内窥镜进行光传递的适应类型:</strong></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">食道癌/胃癌<span style="color: black;">(消化道粘膜穿通或穿孔者除外)</span></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">北青山治疗<span style="color: black;">优良</span></strong></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;"><span style="color: black;">优良</span></strong></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">北青山D.CLINIC以“医疗革新”为口号,致力于开拓创新医疗技术,弥补标准治疗的界限和不足,在癌症治疗方面<span style="color: black;">注意</span>“有尊严的治疗”。北青山D.CLINIC实施的光免疫治疗<span style="color: black;">拥有</span>以下<span style="color: black;">优良</span>:</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">① 各科室癌症专家协同助力</span></strong></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">脑神经外科、消化器官科、<span style="color: black;">呼气</span>器官科、妇科、皮肤科等癌症治疗专家在<span style="color: black;">平常</span>诊疗中彼此<span style="color: black;">供给</span>支援。</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">②激光仪器<span style="color: black;">运用</span>经验丰富</span></strong></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">D.CLINIC从2000年<span style="color: black;">起始</span>,就<span style="color: black;">起始</span><span style="color: black;">运用</span>近红外线激光来进行光疗,在血管激光,皮肤科激光,椎间盘激光等<span style="color: black;">各样</span>各样的激光治疗方面<span style="color: black;">持有</span>丰富的经验和成果。</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">③针对晚期癌症和难治癌症,<span style="color: black;">亦</span>可结合基因治疗</span></strong></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">对标准治疗难以充分<span style="color: black;">掌控</span>的癌症,D.CLINIC<span style="color: black;">亦</span>可<span style="color: black;">供给</span>尖端医疗之一的基因集学性治疗。</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;"><span style="color: black;">④与癌症专科医院联系密切</span></strong></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">若光疗、基因治疗等尖端医疗<span style="color: black;">没</span>法有效医治时,<span style="color: black;">亦</span><span style="color: black;">能够</span><span style="color: black;">举荐</span>至癌症专门医疗<span style="color: black;">公司</span>。</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">光免疫疗法<span style="color: black;">做为</span>一种新的癌症治疗<span style="color: black;">办法</span>正在<span style="color: black;">导致</span>人们的关注。<span style="color: black;">做为</span>一种新型的肿瘤治疗<span style="color: black;">办法</span>,其治疗效果不仅<span style="color: black;">帮忙</span>许多<span style="color: black;">病人</span>摆脱癌症<span style="color: black;">困惑</span>,延长<span style="color: black;">存活</span>期,<span style="color: black;">亦</span>使<span style="color: black;">更加多</span>的癌症<span style="color: black;">病人</span>看到了治疗的<span style="color: black;">期盼</span>。<span style="color: black;">不外</span><span style="color: black;">必须</span><span style="color: black;">重视</span>,<span style="color: black;">每一个</span>癌症<span style="color: black;">病人</span><span style="color: black;">身体</span>的免疫细胞水平和状态都是不同的,<span style="color: black;">详细</span><span style="color: black;">方法</span>还<span style="color: black;">必须</span>经过检测,以及专业的<span style="color: black;">大夫</span><span style="color: black;">评定</span>后决定。</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">‍</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">‍</span><img src="https://mmbiz.qpic.cn/mmbiz_jpg/WpnEBziaB4SOfEia4Avo8frMEfichz7xrIqiaSiaKFrryPvfzBfJVM5vBFRCbe24RC8TELyMHX9hM53yoHbgicwevjQg/640?wx_fmt=jpeg&amp;wxfrom=5&amp;wx_lazy=1&amp;wx_co=1&amp;tp=webp" style="width: 50%; margin-bottom: 20px;"></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">这次</span>“群体抗癌、超越生命 | 2023 癌症诊治科普活动”将</span><span style="color: black;">创建线上咨询、交流群,<span style="color: black;">必须</span>进群得<span style="color: black;">伴侣</span>可添加客服<span style="color: black;">微X</span>(请备注:群体抗癌)。</span></p><img src="https://mmbiz.qpic.cn/mmbiz_jpg/WpnEBziaB4SOfEia4Avo8frMEfichz7xrIqXnG3CsoicoXA5zWKkzc07Bwx13gLtttokEqSUkKQrcMCRxOSiaO1H3oA/640?wx_fmt=jpeg&amp;wxfrom=5&amp;wx_lazy=1&amp;wx_co=1&amp;tp=webp" style="width: 50%; margin-bottom: 20px;"><strong style="color: blue;">添加客服<span style="color: black;">微X</span>,进群咨询、交流</strong>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">癌症治疗</strong><span style="color: black;">是临床医疗中最<span style="color: black;">繁杂</span>的<span style="color: black;">行业</span>之一,<span style="color: black;">触及</span>到多科<span style="color: black;">大夫</span>团队合作(如肿瘤科<span style="color: black;">大夫</span>、放疗<span style="color: black;">大夫</span>、外科<span style="color: black;">大夫</span>和病理科<span style="color: black;">大夫</span>,以及其他专科<span style="color: black;">大夫</span>等)和<span style="color: black;">各样</span>护理保健人员(如护士、放疗师、<span style="color: black;">理学</span>治疗师、药师等)。</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><strong style="color: blue;">治疗计划</strong><span style="color: black;"><span style="color: black;">必须</span><span style="color: black;">思虑</span>癌症的类型,<span style="color: black;">包含</span>其位置、&nbsp;分期(肿瘤<span style="color: black;">体积</span>和扩散<span style="color: black;">状况</span>)、基因特征以及将要接受治疗的<span style="color: black;">病人</span>的<span style="color: black;">详细</span>特征。</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">接受治疗的癌友期望最好的治疗效果,期望有最高的生活质量和最长<span style="color: black;">存活</span>期。</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><span style="color: black;">这次</span>活动<span style="color: black;">尤其</span><span style="color: black;">供给</span><strong style="color: blue;"><span style="color: black;">多学科会诊(MDT)需求登记</span></strong><span style="color: black;">,为众多癌友<span style="color: black;">供给</span>治疗上的<span style="color: black;">帮忙</span>。</span></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><img src="https://mmbiz.qpic.cn/mmbiz_png/WpnEBziaB4SOfEia4Avo8frMEfichz7xrIqcNpIpuQiboBHDsBQVO58U0iaoHerd1Mou0brUEu1aaUKZHOvJl6gzkWQ/640?wx_fmt=png&amp;wxfrom=5&amp;wx_lazy=1&amp;wx_co=1&amp;tp=webp" style="width: 50%; margin-bottom: 20px;"></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;"><strong style="color: blue;">扫描二维码,进行<strong style="color: blue;"><span style="color: black;">MDT</span></strong>需求登记</strong></span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">群体抗癌、超越生命,<span style="color: black;">期盼</span><span style="color: black;">每一个</span><span style="color: black;">癌友都能得到最好的治疗效果,最高的生活质量和最长得<span style="color: black;">存活</span>期。</span></span></p><strong style="color: blue;"><span style="color: black;">
            <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">9月20日14:00~17:00</p>
      </span></strong><strong style="color: blue;"><span style="color: black;">群体抗癌、超越生命 |&nbsp;2023 癌症诊治科普活动</span></strong><strong style="color: blue;"><span style="color: black;">期待与您线下相聚</span></strong>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">参考<span style="color: black;">源自</span>:</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">「光治療(光免疫療法)」https://www.dsurgery.com/treatment/pdt</span></p>
    <p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">免责声明:本公众号内容仅作交流使参考,不<span style="color: black;">做为</span>诊断及医疗依据,专业医学问题请咨询专业人士或专业医疗<span style="color: black;">公司</span>。</span></p><strong style="color: blue;"><span style="color: black;">举荐</span>阅读:</strong><a style="color: black;"><span style="color: black;"><strong style="color: blue;">1.&nbsp;<span style="color: black;">“神药”二甲双胍治疗<span style="color: black;">各样</span>癌症,确实有效!</span></strong></span></a><a style="color: black;"><span style="color: black;"><strong style="color: blue;">2.&nbsp;<span style="color: black;">恶性肿瘤<span style="color: black;">病人</span><span style="color: black;">恢复</span>期营养管理专家共识( 2023 版)</span></strong></span></a><a style="color: black;"><span style="color: black;"><strong style="color: blue;">3.&nbsp;<span style="color: black;">肿瘤一线二线三线治疗<span style="color: black;">怎样</span>定义?<span style="color: black;">怎样</span>计算肿瘤的治疗线数?</span></strong></span></a><a style="color: black;"><span style="color: black;"><strong style="color: blue;">4.&nbsp;<span style="color: black;">“PET-CT”、“<span style="color: black;">加强</span>CT”,到底有什</span></strong></span></a><strong style="color: blue;">么不同?</strong><a style="color: black;"><span style="color: black;"><strong style="color: blue;">5.&nbsp;<span style="color: black;">大剂量维生素C抗肿瘤,确有疗效!</span></strong></span></a><a style="color: black;"><span style="color: black;"><strong style="color: blue;">6.&nbsp;<span style="color: black;">“烫死”癌细胞,43℃<span style="color: black;">刚才</span>好!</span></strong></span></a><strong style="color: blue;"><span style="color: black;">——本期完——</span></strong><strong style="color: blue;"><span style="color: black;"><span style="color: black;">咱们</span>(医世象,<span style="color: black;">微X</span>ID:medhealife)</span></strong><span style="color: black;">致力于肿瘤<span style="color: black;">行业</span>的<span style="color: black;">研究</span>成果<span style="color: black;">报告</span>,以及科普知识的传播;</span><span style="color: black;">关注于肿瘤预防、早筛早诊、治疗以及<span style="color: black;">恢复</span>管理等肿瘤全生命周期管理;</span><span style="color: black;">为<span style="color: black;">大夫</span>、<span style="color: black;">病人</span>以及<span style="color: black;">关联</span>人员<span style="color: black;">供给</span>最新的实讯;</span><span style="color: black;">为医学惠民贡献一份力量。<span style="color: black;">‍</span></span><span style="color: black;">‍</span><img src="https://mmbiz.qpic.cn/mmbiz_jpg/WpnEBziaB4SOibgGmBMp5CTLDgNe2iaM7O5kcianTs1epTPficopBag6y6N7RRFnqNeAd9yr14X8fnH4B38N5MnUWUw/640?wx_fmt=jpeg&amp;wxfrom=5&amp;wx_lazy=1&amp;wx_co=1&amp;tp=webp" style="width: 50%; margin-bottom: 20px;">




流星的美 发表于 2024-9-1 21:11:42

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4lqedz 发表于 2024-9-27 23:01:39

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qzmjef 发表于 5 天前

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