原创 癌症相关重磅科研最新发展(2024年3月）
<h1 style="color: black; text-align: left; margin-bottom: 10px;">【1】Cell Res：北京大学杨竞团队揭示癌细胞劫持神经系统的机制</h1>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2024-03-14<span style="color: black;">报告</span>，北京大学生命科学学院杨竞团队在 Cell Research 期刊<span style="color: black;">发布</span>了题为：Multiple cancer cell types release LIF and Gal3 to hijack neural signals 的<span style="color: black;">科研</span>论文。 该<span style="color: black;">科研</span><span style="color: black;">发掘</span>并证实了多种癌细胞类型<span style="color: black;">经过</span>释放两种细胞因子白血病<span style="color: black;">控制</span>因子（LIF）和半乳糖凝集素3（Gal3）来触发大脑激活，而阻断LIF或Gal3信号转导<span style="color: black;">能够</span>消除大脑反应并<span style="color: black;">剧烈</span><span style="color: black;">控制</span>肿瘤生长。 这些结果阐明了多种癌细胞类型劫持神经系统促进肿瘤<span style="color: black;">发展</span>的一种新型、共享的机制。这对我们更好地理解癌症神经科学的<span style="color: black;">繁杂</span>性<span style="color: black;">拥有</span>广泛<span style="color: black;">道理</span>，<span style="color: black;">亦</span>提出了一种针对癌症-神经相互<span style="color: black;">功效</span>的新型癌症治疗手段——癌症神经疗法。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="//q4.itc.cn/images01/20240314/5cdf9dcd3e834f3081ce4ac8fad4cbc9.png" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">总的<span style="color: black;">来讲</span>，该<span style="color: black;">科研</span>阐明了多种癌症类型劫持神经系统信号以促进肿瘤<span style="color: black;">发展</span>的新型、共享机制，这对<span style="color: black;">咱们</span>更好地理解癌症神经科学的<span style="color: black;">繁杂</span>性<span style="color: black;">拥有</span>广泛<span style="color: black;">道理</span>，<span style="color: black;">亦</span>提出了一种针对癌症-神经相互<span style="color: black;">功效</span>的新型癌症治疗手段——癌症神经疗法。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">【2】《自然·癌症》：<span style="color: black;">专家</span><span style="color: black;">发掘</span>肝转移专属基因突变，PI3K<span style="color: black;">控制</span>剂联合SGLT2<span style="color: black;">控制</span>剂或生酮<span style="color: black;">膳食</span>有望破解！</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2024-03-14<span style="color: black;">报告</span>，美国哥伦比亚大学的Benjamin Izar等人<span style="color: black;">发布</span>在《自然·癌症》期刊上的最新<span style="color: black;">科研</span>，找到了驱动癌症肝转移的专属基因变异。 Pip4k2c是一种激酶的编码基因，<span style="color: black;">科研</span>者们<span style="color: black;">发掘</span>，Pip4k2c缺失突变能够<span style="color: black;">帮忙</span>肿瘤细胞更加有效地利用胰岛素来促进<span style="color: black;">自己</span>生长，从而特异性地驱动肿瘤细胞向<span style="color: black;">饱含</span>胰岛素的肝脏转移。 PI3K<span style="color: black;">控制</span>剂与SGLT2<span style="color: black;">控制</span>剂或生酮<span style="color: black;">膳食</span>联合治疗，<span style="color: black;">能够</span>在<span style="color: black;">掌控</span>胰岛素水平的<span style="color: black;">同期</span>，减少Pip4k2c缺失介导的肝转移。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="//q5.itc.cn/images01/20240314/374e12769df34085899ac3430bd96bb7.png" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">【3】Nat Commun：揭示融合蛋白拦截基因调节子从而诱发儿童癌症的分子机制</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2024-03-13<span style="color: black;">报告</span>，<span style="color: black;">近期</span>，一篇<span style="color: black;">发布</span>在国际杂志Nature Communications上题为“Heterotypic interactions can drive selective co-condensation of prion-like low-complexity domains of FET proteins and mammalian SWI/SNF complex”的<span style="color: black;">科研</span>报告中，来自布法罗大学等<span style="color: black;">公司</span>的<span style="color: black;">专家</span>们<span style="color: black;">经过</span><span style="color: black;">科研</span>揭示了融合蛋白<span style="color: black;">怎样</span>拦截基因调节子从而刺激儿童癌症的<span style="color: black;">出现</span>。 <span style="color: black;">文案</span>中，<span style="color: black;">科研</span>人员<span style="color: black;">发掘</span>，<span style="color: black;">叫作</span>之为融合蛋白的一组<span style="color: black;">反常</span>蛋白或能与一组开启和关闭基因表达的蛋白进行<span style="color: black;">反常</span>结合，<span style="color: black;">因此呢</span>，本应该被激活的基因却会被<span style="color: black;">控制</span>，而应该被<span style="color: black;">控制</span>的基因则会被激活，从而就<span style="color: black;">诱发</span>了癌症。 这项<span style="color: black;">科研</span>中，<span style="color: black;">科研</span>人员对这种劫持<span style="color: black;">暗地里</span>的分子机制有了新的见解，<span style="color: black;">她们</span><span style="color: black;">发掘</span>，融合蛋白和一种基因调节蛋白复合体能<span style="color: black;">经过</span>其未展开且松散的区域（<span style="color: black;">叫作</span>之为<span style="color: black;">没</span>序结构域，disordered domains）<span style="color: black;">出现</span>相互<span style="color: black;">功效</span>。尽管其<span style="color: black;">持有</span>模糊的性质，但这种<span style="color: black;">没</span>序结构域能<span style="color: black;">经过</span>形成液体样的液滴并将其混合均匀，从而就<span style="color: black;">拥有</span>高度的特异性。 <span style="color: black;">科研</span>者Priya Banerjee说道，有<span style="color: black;">海量</span><span style="color: black;">科研</span>证据<span style="color: black;">显示</span>，蛋白质的<span style="color: black;">错乱</span>区域或许在癌症和其它<span style="color: black;">重点</span>的人类<span style="color: black;">疾患</span><span style="color: black;">出现</span>过程中扮演<span style="color: black;">重要</span>角色，但问题在于其是<span style="color: black;">怎样</span>发挥<span style="color: black;">功效</span>的，本文中，<span style="color: black;">科研</span>人员<span style="color: black;">经过</span><span style="color: black;">科研</span><span style="color: black;">发掘</span>，融合蛋白和基因调节蛋白复合体之间的<span style="color: black;">重要</span>网络事件能<span style="color: black;">经过</span>这种<span style="color: black;">没</span>序的结构域<span style="color: black;">出现</span>，<span style="color: black;">况且</span>这一过程<span style="color: black;">拥有</span><span style="color: black;">必定</span>的化学特异性。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">科研</span>者<span style="color: black;">暗示</span>，这项<span style="color: black;">基本</span>性<span style="color: black;">科研</span>非常<span style="color: black;">要紧</span>，除非<span style="color: black;">科研</span>人员完全理解<span style="color: black;">隐匿</span>在致命人类<span style="color: black;">疾患</span><span style="color: black;">暗地里</span>的分子机制，否则就<span style="color: black;">没</span>法<span style="color: black;">研发</span>出新型疗法对其进行治疗。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">原文；doi：10.1038/s41467-024-44945-5</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">【4】Adv Sci：青岛市市立医院付涛团队揭示环状RNA<span style="color: black;">控制</span>结直肠癌的机制</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2024-03-13<span style="color: black;">报告</span>，青岛市市立医院付涛团队在 Advanced Science 期刊<span style="color: black;">发布</span>了题为：CircFBXW4 Suppresses Colorectal Cancer Progression by Regulating the MiR-338-5p/SLC5A7 Axis 的<span style="color: black;">科研</span>论文。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">该<span style="color: black;">科研</span><span style="color: black;">显示</span>，circFBXW4在结直肠癌中<span style="color: black;">做为</span>一种新型肿瘤<span style="color: black;">控制</span>因子，circFBXW4<span style="color: black;">经过</span>调节miR-338-5p/SLC5A7轴<span style="color: black;">控制</span>结直肠癌<span style="color: black;">发展</span>，为结直肠癌的治疗<span style="color: black;">供给</span>了潜在新靶点。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="//q4.itc.cn/images01/20240314/8b7fc252a2ea44d7a86fb18db1378ed1.png" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">该<span style="color: black;">科研</span>采用RNA测序和生物信息学分析筛选<span style="color: black;">反常</span>表达的circRNA，<span style="color: black;">经过</span>实时定量PCR检测结直肠癌组织和细胞株中circFBXW4的表达，结果<span style="color: black;">表示</span>，在结直肠癌组织和细胞株中，circFBXW4<span style="color: black;">明显</span>下调。而circFBXW4的下调与结直肠癌的恶性特征和<span style="color: black;">病人</span>总体<span style="color: black;">存活</span>率<span style="color: black;">显著</span><span style="color: black;">关联</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">总的<span style="color: black;">来讲</span>，该<span style="color: black;">科研</span>揭示了circFBXW4<span style="color: black;">经过</span>miR-338-5p/SLC5A7轴<span style="color: black;">控制</span>结直肠癌<span style="color: black;">发展</span>的<span style="color: black;">详细</span><span style="color: black;">重要</span><span style="color: black;">功效</span>，为结直肠癌的治疗<span style="color: black;">供给</span>了潜在新靶点。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">原文；CircFBXW4 Suppresses Colorectal Cancer Progression by Regulating the MiR-338-5p/SLC5A7 Axis</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">【5】Cancer Discov | 北京大学汤富酬/周鑫揭示了结直肠癌分子亚型的表观遗传<span style="color: black;">基本</span>和特征转录因子</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2024-03-12<span style="color: black;">报告</span>，北京大学汤富酬及周鑫<span style="color: black;">一起</span>通讯在Cancer Discovery（IF 28）在线<span style="color: black;">发布</span>题为“Single-cell chromatin accessibility analysis reveals the epigenetic basis and signature transcription factors for the molecular subtypes of colorectal cancers”的<span style="color: black;">科研</span>论文，该<span style="color: black;">科研</span>利用单细胞染色质可及性分析揭示了结直肠癌分子亚型的表观遗传<span style="color: black;">基本</span>和特征转录因子。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="//q7.itc.cn/images01/20240314/ef8c47a663e84262b3727ba8ef872f23.png" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">为了绘制CRC的表观遗传图谱，<span style="color: black;">科研</span>人员对29例<span style="color: black;">病人</span>的上皮细胞制作了高质量的单细胞染色质可及性图谱。在腺瘤中<span style="color: black;">得到</span>的<span style="color: black;">反常</span>染色质状态在很大程度上<span style="color: black;">保存</span>在CRC中，这与相反的DNA甲基化变化密切<span style="color: black;">关联</span>。恶性细胞的<span style="color: black;">没</span>监督分析<span style="color: black;">发掘</span>了两个表观遗传亚型，与iCMS<span style="color: black;">归类</span>完全匹配，并鉴定出iCMS特异性转录因子，<span style="color: black;">包含</span>iCMS2肿瘤的HNF4A、PPARA和iCMS3肿瘤的FOXA3、MAFK。值得<span style="color: black;">重视</span>的是，亚型特异性TF结合<span style="color: black;">区别</span>的靶基因集，并有助于<span style="color: black;">病人</span>间染色质可及性和RNA表达的<span style="color: black;">类似</span>性和多样性。<span style="color: black;">另外</span>，还鉴定了CpG岛甲基化表型，并确定了CIMP-High亚型的染色质状态特征和TF 调节因子。该<span style="color: black;">科研</span>系统地揭示了著名的iCMS和CIMP<span style="color: black;">归类</span>的CRCs的表观遗传学<span style="color: black;">基本</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">【6】哈佛大学<span style="color: black;">科研</span><span style="color: black;">发掘</span>，维生素D、ω-3、运动，患癌<span style="color: black;">危害</span>降低60%以上</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2024-03-11<span style="color: black;">报告</span>，日前，瑞士苏黎世大学、美国哈佛大学的<span style="color: black;">科研</span>人员在" Frontiers in Aging "期刊上<span style="color: black;">发布</span>了一篇题为" Combined Vitamin D，Omega-3 Fatty Acids，and a Simple Home Exercise Program May Reduce Cancer Risk Among Active Adults Aged 70 and Older：A Randomized Clinical Trial "的<span style="color: black;">科研</span>论文。 该<span style="color: black;">科研</span><span style="color: black;">发掘</span>，简单的三种生活方式改变，高剂量维生素D、Omega-3和简单的家庭<span style="color: black;">熬炼</span>计划<span style="color: black;">能够</span>将70岁以上老年人患癌<span style="color: black;">危害</span>降低61%。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="//q7.itc.cn/images01/20240314/ff10f56fcb824768ac3073f8a3765bdf.jpeg" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">在该<span style="color: black;">科研</span>中，<span style="color: black;">科研</span>人员分析了一项在瑞士、法国、德国、奥地利和葡萄牙进行的为期三年，多中心、随机、双盲的<span style="color: black;">实验</span> DO-HEALTH，共纳入2157名70岁以上的健康成年人参与者。目的是测试一种有<span style="color: black;">期盼</span>的癌症预防联合<span style="color: black;">干涉</span><span style="color: black;">办法</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">总之，这三种简单的<span style="color: black;">办法</span>被证明有利于减轻癌症<span style="color: black;">包袱</span>，可能会影响老年人侵袭性癌症预防的<span style="color: black;">将来</span>。<span style="color: black;">将来</span>的<span style="color: black;">科研</span>应验证联合治疗在预防癌症方面的益处，还应扩展到超过本<span style="color: black;">实验</span><span style="color: black;">评定</span>的三年<span style="color: black;">连续</span>时间的更长随访时间。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">【7】Cell Rep：识别出能防止特殊乳腺癌亚型<span style="color: black;">出现</span>转移的新型蛋白</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2024-03-11<span style="color: black;">报告</span>，<span style="color: black;">近期</span>，一篇<span style="color: black;">发布</span>在国际杂志Cell Reports上题为“In vivo CRISPR knockout screen identifies p47 as a suppressor of HER2+ breast cancer metastasis by regulating NEMO trafficking and autophagy flux”的<span style="color: black;">科研</span>报告中，来自辛辛那提大学医学院等<span style="color: black;">公司</span>的<span style="color: black;">专家</span>们<span style="color: black;">经过</span><span style="color: black;">科研</span>识别出了一种新型蛋白，其或能<span style="color: black;">帮忙</span>防止HER2阳性的乳腺癌亚型<span style="color: black;">出现</span>转移，大约20%的乳腺癌<span style="color: black;">病人</span>都是HER2阳性的乳腺癌，<span style="color: black;">况且</span>这一类癌症相比其它癌症类型而言更具侵袭性。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">非常多</span><span style="color: black;">科研</span>人员一次专注于一种蛋白或基因，但一次<span style="color: black;">针对</span><span style="color: black;">非常多</span>基因开展系统性有影响的<span style="color: black;">科研</span>却<span style="color: black;">必须</span>特定的专业知识，此前的<span style="color: black;">科研</span>或许就为本文<span style="color: black;">科研</span>奠定了<span style="color: black;">必定</span>的<span style="color: black;">基本</span>。综上，本文<span style="color: black;">科研</span>结果阐明了p47在乳腺癌转移调节过程中的<span style="color: black;">重要</span>角色和机制，<span style="color: black;">同期</span><span style="color: black;">科研</span>人员还强调了利用p47<span style="color: black;">做为</span>HER2阳性乳腺癌细胞<span style="color: black;">经过</span>多种通路发生转移的<span style="color: black;">控制</span>因子的<span style="color: black;">潜能</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">原文；doi:10.1016/j.celrep.2024.113780</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">【8】《癌细胞》：慢性压力设下癌症转移“陷阱”！<span style="color: black;">专家</span><span style="color: black;">发掘</span>，慢性压力会<span style="color: black;">促进</span>中性粒细胞释放NET，塑造有利癌症转移的微环境</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2024-03-11<span style="color: black;">报告</span>，<span style="color: black;">近期</span>一篇<span style="color: black;">发布</span>在Cancer Cell期刊上的最新论文<span style="color: black;">更加是</span>提出，慢性压力还会使得<span style="color: black;">咱们</span>的免疫卫士中性粒细胞负能量满满，反倒打造出促进肿瘤转移的温床。 美国冷泉港实验室的Mikala Egeblad团队<span style="color: black;">发掘</span>，慢性压力诱导机体释放的糖皮质激素，会改变中性粒细胞的正常昼夜节律，并<span style="color: black;">促进</span>其释放一种<span style="color: black;">叫作</span>为中性粒细胞胞外陷阱（NET）的结构，从而<span style="color: black;">形成</span>有助于肿瘤细胞转移的微环境。<span style="color: black;">运用</span>酶减少NET水平，能够减少乳腺癌细胞向小鼠肺部转移。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="//q7.itc.cn/images01/20240314/42d738af5d3c4db9a8368c3434d72cb9.png" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">【9】Cell子刊：李汉杰/陈昶/王光锁/陈云团队绘制<span style="color: black;">初期</span>肺腺癌免疫动态图谱，揭示Tfh细胞抗肿瘤机制</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2024-03-11<span style="color: black;">报告</span>，中国科学院深圳先进技术<span style="color: black;">科研</span>院李汉杰<span style="color: black;">科研</span>员、上海市肺科医院陈昶教授、深圳市人民医院王光锁教授及南京医科大学陈云教授等在 Cell 子刊 Cell Reports Medicine 上<span style="color: black;">发布</span>了题为：An immune cell map of human lung adenocarcinoma development reveals an anti-tumoral role of the Tfh-dependent tertiary lymphoid structure 的<span style="color: black;">科研</span>论文。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="//q3.itc.cn/images01/20240314/d6856ad0603b4a01b9ad7c4c0b94b978.png" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">该<span style="color: black;">科研</span><span style="color: black;">发掘</span>，在肿瘤<span style="color: black;">出现</span>/侵袭过程中，滤泡辅助性T细胞（Tfh）样细胞、生发中心B细胞和功能失调的CD8+细胞<span style="color: black;">增多</span>，并在肿瘤内部形成三级淋巴结构（TLS）。TLS结构始于CD4+T细胞的聚集和表达CXCL13的Tfh样细胞的产生，随后是B细胞的<span style="color: black;">累积</span>，<span style="color: black;">而后</span>形成CD4+T和B细胞聚集体。TLS及其<span style="color: black;">关联</span>细胞与更好的<span style="color: black;">病人</span><span style="color: black;">存活</span><span style="color: black;">关联</span>。<span style="color: black;">经过</span>Tfh或B细胞的消耗来<span style="color: black;">控制</span>TLS的形成，促进了小鼠模型的肿瘤生长。Tfh依赖的TLS的抗肿瘤<span style="color: black;">功效</span>是<span style="color: black;">经过</span>IL-21-IL-21受体信号转导实现的。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">这些<span style="color: black;">发掘</span>证实了Tfh细胞依赖的三级淋巴结构（TLS）在肺腺癌（LUAD）<span style="color: black;">出现</span>和发展中的抗肿瘤<span style="color: black;">功效</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">【10】Cancer Cell：激活维A酸受体，可重编程衰老反应，<span style="color: black;">加强</span>NK细胞抗肿瘤活性</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2024-03-10<span style="color: black;">报告</span>，Cancer Cell 期刊<span style="color: black;">发布</span>了一篇题为：Retinoic acid receptor activation reprograms senescence response and enhances anti-tumor activity of natural killer cells 的<span style="color: black;">科研</span>论文。 该<span style="color: black;">科研</span><span style="color: black;">发掘</span>，维A酸受体（RAR）激动剂阿达帕林（Adapalene）是前列腺癌（PCa）中一种有效的促衰老化合物，对RAR的激活<span style="color: black;">诱发</span>了强有力的促衰老反应和肿瘤<span style="color: black;">控制</span>性衰老<span style="color: black;">关联</span>分泌表型（SASP）。将阿达帕林（Adapalene）与前列腺癌的标准化疗<span style="color: black;">药品</span>多西他赛（Docetaxel）联合<span style="color: black;">运用</span>，可更好地促进肿瘤<span style="color: black;">控制</span>性SASP，更有效地<span style="color: black;">加强</span>自然杀伤（NK）细胞介导的肿瘤清除，从而提出了一种在免疫冷肿瘤中刺激抗肿瘤免疫反应的替代治疗策略。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="//q3.itc.cn/images01/20240314/9c8e7b498a5443de8298a38711764b23.png" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">【11】PLOS Med：<span style="color: black;">检测</span>子宫<span style="color: black;">情况</span>或能降低女性患子宫内膜癌的<span style="color: black;">危害</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2024-03-10<span style="color: black;">报告</span>，<span style="color: black;">近期</span>，一篇<span style="color: black;">发布</span>在国际杂志PLOS Medicine上题为“Diagnosis and management of endometrial hyperplasia: A UK national audit of adherence to national guidance 2012–2020”的<span style="color: black;">科研</span>报告中，来自牛津大学等<span style="color: black;">公司</span>的<span style="color: black;">专家</span>们<span style="color: black;">经过</span><span style="color: black;">科研</span><span style="color: black;">发掘</span>，<span style="color: black;">针对</span><span style="color: black;">诱发</span>子宫内膜过度增厚<span style="color: black;">疾患</span>的女性而言，改善其健康护理或许能<span style="color: black;">帮忙</span>降低患癌<span style="color: black;">危害</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">本文<span style="color: black;">科研</span>结果<span style="color: black;">显示</span>，<span style="color: black;">按照</span>国家指南，子宫内膜增生<span style="color: black;">病人</span>的护理<span style="color: black;">已然</span><span style="color: black;">出现</span>了改变，<span style="color: black;">更加多</span>的女性<span style="color: black;">常常</span>会接受非不典型子宫内膜增生的一线治疗，并进行组织学回归随访；而<span style="color: black;">针对</span><span style="color: black;">哪些</span>并未进行子宫切除术的不典型子宫内膜增生<span style="color: black;">病人</span>的随访则<span style="color: black;">必要</span>得到改善，<span style="color: black;">由于</span>其共存癌症和患癌<span style="color: black;">危害</span>较高。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">原文；DOI:10.1371/journal.pmed.1004346</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">【12】Oncoscience：社论<span style="color: black;">文案</span>揭示<span style="color: black;">研发</span>治疗人类转移性肿瘤新型疗法的曲折之路</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2024-03-09<span style="color: black;">报告</span>，<span style="color: black;">近期</span>，一篇<span style="color: black;">发布</span>在国际杂志Oncoscience上题为“A very long and winding road: developing novel therapeutics for metastatic tumors”的社论<span style="color: black;">文案</span>中，来自弗吉尼亚联邦大学的<span style="color: black;">科研</span>人员<span style="color: black;">暗示</span>，尽管免疫疗法<span style="color: black;">近期</span>在治疗诸如非小细胞肺癌（NSCLC，non-small cell lung cancer）和皮肤黑色素瘤上取得了<span style="color: black;">必定</span>的成功，但转移到远端（<span style="color: black;">例如</span>大脑）的肿瘤<span style="color: black;">一般</span>却是<span style="color: black;">没</span>法治疗和应对的。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">然而，<span style="color: black;">亦</span>有相当多的<span style="color: black;">科研</span>证据<span style="color: black;">显示</span>，免疫疗法或许会在某些非小细胞肺癌、黑色素瘤和头颈鳞状细胞癌（NHSCC）<span style="color: black;">病人</span>中<span style="color: black;">导致</span><span style="color: black;">疾患</span>的超级<span style="color: black;">发展</span>，非小细胞肺癌<span style="color: black;">病人</span>机体中的肿瘤<span style="color: black;">常常</span>含有METex14和MDM2的扩增形式。<span style="color: black;">日前</span>有多个问题阻碍了<span style="color: black;">专家</span>们对原位和转移性实体瘤更为有效的<span style="color: black;">掌控</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><img src="//q8.itc.cn/images01/20240314/ed1f075a233f445e9877518925170dfc.png" style="width: 50%; margin-bottom: 20px;"></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">首要</span>，驱动癌症表型的突变<span style="color: black;">一般</span>是细胞生物学中微小变化的组合，其中任何一个<span style="color: black;">倘若</span>被靶向<span style="color: black;">功效</span>的话，仅会对肿瘤的生长和<span style="color: black;">存活</span>产生适度的影响；从概念上来讲，这或许就<span style="color: black;">需求</span><span style="color: black;">科研</span>人员立即<span style="color: black;">运用</span>两种和三种<span style="color: black;">药品</span>联合起来阻断<span style="color: black;">重要</span>的信号通路，从而实现肿瘤的有效<span style="color: black;">掌控</span>，而<span style="color: black;">没</span>论肿瘤的耐药性机制<span style="color: black;">是不是</span>会<span style="color: black;">出现</span>进化。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">其次，改变细胞生物学的一个必然结果<span style="color: black;">便是</span>，越来越少的肿瘤携带<span style="color: black;">拥有</span>单一可识别的驱动癌基因，而肿瘤细胞对其生长和<span style="color: black;">存活</span>都<span style="color: black;">尤其</span>依赖，<span style="color: black;">例如</span>突变的RAS蛋白、突变的EGF受体和其它突变的MET、RET和HER2受体等。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">最后<span style="color: black;">科研</span>者Dent指出，即使在这种<span style="color: black;">状况</span>下，诸如此类肿瘤<span style="color: black;">亦</span><span style="color: black;">必须</span>利用两种或三种<span style="color: black;">药品</span>组合来进行联合治疗，<span style="color: black;">同期</span>还能阻断<span style="color: black;">重点</span>的驱动癌基因，并阻断<span style="color: black;">重点</span>进化耐药机制的信号，<span style="color: black;">乃至</span>还会阻断来自癌症次级<span style="color: black;">存活</span>通路的信号转导。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">原文；doi:10.18632/oncoscience.595</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">【13】Aging：<span style="color: black;">专家</span>成功绘制出人类结肠成纤维细胞的核心衰老表型图谱</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2024-03-09<span style="color: black;">报告</span>，<span style="color: black;">近期</span>，一篇<span style="color: black;">发布</span>在国际杂志Aging上题为“Mapping the core senescence phenotype of primary human colon fibroblasts”的<span style="color: black;">科研</span>报告中，来自Fred Hutchinson癌症<span style="color: black;">科研</span>中心等<span style="color: black;">公司</span>的<span style="color: black;">专家</span>们<span style="color: black;">经过</span><span style="color: black;">科研</span>绘制出了人类结肠成纤维细胞的核心衰老表型图谱。 <span style="color: black;">科研</span>者<span style="color: black;">暗示</span>，结直肠癌<span style="color: black;">病人</span>的结肠中的衰老细胞的数量会<span style="color: black;">增多</span>，<span style="color: black;">况且</span>衰老成纤维细胞及其SASP会在结肠中制造促进结直肠癌开端和<span style="color: black;">发展</span>的微生境（microniches），然而，SASP的<span style="color: black;">构成</span>是异质性的且<span style="color: black;">拥有</span>细胞特异性，<span style="color: black;">日前</span><span style="color: black;">科研</span>人员并<span style="color: black;">无</span><span style="color: black;">知道</span>定义结肠成纤维细胞的精确衰老特征。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">本文<span style="color: black;">科研</span>绘制出了人类结肠成纤维细胞的核心衰老表型图谱，有望<span style="color: black;">帮忙</span><span style="color: black;">研发</span>治疗人类结直肠癌的新型个体化疗法。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">【14】《自然》子刊：<span style="color: black;">专家</span><span style="color: black;">发掘</span>癌症<span style="color: black;">关联</span>成纤维细胞分泌醋酸、加速胰腺癌<span style="color: black;">出现</span>的机制！</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2024-03-09<span style="color: black;">报告</span>，<span style="color: black;">近期</span>，美国内布拉斯加大学<span style="color: black;">科研</span>团队在《自然·细胞生物学》（Nature Cell Biology）上<span style="color: black;">发布</span>的最新<span style="color: black;">科研</span>成果，就<span style="color: black;">发掘</span>帮“癌王”胰腺癌吃醋的还是熟面孔——肿瘤<span style="color: black;">关联</span>成纤维细胞（CAFs）：由CAFs分泌的醋酸会<span style="color: black;">经过</span>表观遗传机制（乙酰化），<span style="color: black;">加强</span>癌细胞内<span style="color: black;">重要</span>转录因子SP1稳定性及转录活性，<span style="color: black;">从而</span>上调对胰腺癌细胞生存和增殖极为<span style="color: black;">要紧</span>的SAT1表达。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">在SAT1基因的<span style="color: black;">起步</span>子区域，<span style="color: black;">科研</span>者们又<span style="color: black;">发掘</span>了转录因子SP1的富集，它的存在<span style="color: black;">亦</span>与H3K27乙酰化修饰水平高度<span style="color: black;">关联</span>，而SP1<span style="color: black;">一样</span>是醋酸处理后被乙酰化修饰的蛋白质之一，其赖氨酸19残基（Lysine 19）位点是乙酰化修饰位点。总而言之，ACSS2–SP1–SAT1这条调控轴是CAFs分泌醋酸，助力PDAC细胞<span style="color: black;">存活</span>和加速生长的<span style="color: black;">重要</span>环节，值得开展治疗<span style="color: black;">干涉</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">【15】Gut：粘液或会<span style="color: black;">促进</span>“<span style="color: black;">青年</span>”胰腺癌细胞生长但会阻断其<span style="color: black;">出现</span>致命性转化</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2024-03-09<span style="color: black;">报告</span>，<span style="color: black;">近期</span>，一篇<span style="color: black;">发布</span>在国际杂志Gut上题为“A mucus production programme promotes classical pancreatic ductal adenocarcinoma”的<span style="color: black;">科研</span>报告中，来自冷泉港实验室等<span style="color: black;">公司</span>的<span style="color: black;">专家</span>们<span style="color: black;">经过</span><span style="color: black;">科研</span>揭示了参与胰腺癌转化的一种新型机制——粘液。在<span style="color: black;">疾患</span><span style="color: black;">出现</span>的<span style="color: black;">初期</span><span style="color: black;">周期</span>，胰腺癌会产生粘液，<span style="color: black;">另外</span>，这些细胞依赖于机体粘液产生的调节子，这一<span style="color: black;">科研</span><span style="color: black;">发掘</span>或能为<span style="color: black;">将来</span><span style="color: black;">研发</span>新型诊断技术或治疗性策略奠定<span style="color: black;">必定</span>的<span style="color: black;">基本</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">本文<span style="color: black;">科研</span>结果扩展了<span style="color: black;">专家</span>们对癌前病变和经典分化的胰腺导管腺癌中转录程序激活的理解，并能确定在这些细胞状态下粘液产生的调节子或许<span style="color: black;">便是</span>特殊的易感性，<span style="color: black;">同期</span><span style="color: black;">科研</span>人员还揭示了表型转换或许能<span style="color: black;">做为</span>对分化状态起决定<span style="color: black;">功效</span>的反应性机制。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">原文；DOI:10.1136/gutjnl-2023-329839</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">【16】J Med Virol：揭示HPV感染在人类头颈鳞状细胞癌微环境中所扮演的<span style="color: black;">重要</span>角色</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2024-03-08<span style="color: black;">报告</span>，<span style="color: black;">近期</span>，一篇<span style="color: black;">发布</span>在国际杂志Journal of Medical Virology上题为“Deciphering head and neck cancer microenvironment: Single‐cell and spatial transcriptomics reveals human papillomavirus‐associated differences”的<span style="color: black;">科研</span>报告中，来自釜山国立大学等<span style="color: black;">公司</span>的<span style="color: black;">专家</span>们在一项开创性的<span style="color: black;">科研</span>中分析了在HPV感染状态下HNSCC复杂肿瘤微环境中的细胞多样性和分子属性。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">这项<span style="color: black;">科研</span>中，<span style="color: black;">科研</span>人员利用HPV阴性和HPV阳性<span style="color: black;">病人</span>的样本进行单细胞RNA分析（一种基因测序技术）和空间转录组学分析（ST，spatial transcriptomics，一种先进的分子分析技术），<span style="color: black;">同期</span>还对原发性肿瘤和淋巴结转移性肿瘤（LNMTs）样本进行了<span style="color: black;">关联</span>分析，深入<span style="color: black;">科研</span>的结果或能为揭示HPV感染和HNSCC<span style="color: black;">出现</span>之间的<span style="color: black;">繁杂</span><span style="color: black;">相关</span><span style="color: black;">供给</span><span style="color: black;">明显</span>的图像——在HPV阳性的HNSCC<span style="color: black;">状况</span>下，免疫细胞就能积极参与肿瘤的<span style="color: black;">出现</span>，HNSCC的分子特征会受到HPV感染状态的<span style="color: black;">显著</span>影响，而并不是肿瘤的<span style="color: black;">实质</span>位置。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">本文<span style="color: black;">科研</span><span style="color: black;">加强</span>了<span style="color: black;">专家</span>们<span style="color: black;">针对</span>人类头颈鳞状细胞癌（HNSCC）微环境的理解，其或有望<span style="color: black;">帮忙</span><span style="color: black;">指点</span>HNSCC疗法的<span style="color: black;">研发</span>，尤其是在<span style="color: black;">控制</span>癌细胞生长和迁移方面；<span style="color: black;">因此呢</span>，HPV感染或许会被视为制定疗法策略的一种标准，从而就能促进<span style="color: black;">专家</span>们<span style="color: black;">研发</span>针对<span style="color: black;">区别</span><span style="color: black;">病人</span>的<span style="color: black;">精细</span>个体化治疗策略。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">原文:DOI:10.1002/jmv.29386</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">【17】《胃肠病学》：华科同济医院团队揭示介导肝癌微环境免疫<span style="color: black;">控制</span>的<span style="color: black;">要紧</span>靶点！</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2024-03-08<span style="color: black;">报告</span>，<span style="color: black;">近期</span>，华中科技大学同济医学院<span style="color: black;">附庸</span>同济医院夏丽敏课题组在Gastroenterology期刊<span style="color: black;">发布</span>的最新<span style="color: black;">科研</span>成果，就揭示了肝细胞癌（HCC）中存在的一个“找打”型靶点——转录因子SOX18，它会<span style="color: black;">同期</span>促进肿瘤<span style="color: black;">关联</span>巨噬细胞（TAMs）和调节性T细胞（Tregs）向HCC微环境中<span style="color: black;">海量</span>浸润，<span style="color: black;">从而</span>介导微环境免疫<span style="color: black;">控制</span>、促进HCC的<span style="color: black;">发展</span>和远处转移。 <span style="color: black;">科研</span><span style="color: black;">表示</span>，SOX18表达水平会在TGF-β1-Smad2/3轴的诱导下<span style="color: black;">出现</span>上调，<span style="color: black;">从而</span><span style="color: black;">经过</span>转录激活PD-L1和趋化因子CXCL12，促进TAMs和Tregs在HCC微环境中<span style="color: black;">海量</span>浸润，<span style="color: black;">控制</span>CD8+T细胞对癌细胞的毒性杀伤；针对<span style="color: black;">以上</span>调节机制中的<span style="color: black;">重要</span>环节，如<span style="color: black;">运用</span>CXCR4（CXCL12配体）<span style="color: black;">控制</span>剂或TGFβR1<span style="color: black;">控制</span>剂，<span style="color: black;">就可</span>破解SOX18介导的免疫<span style="color: black;">控制</span>，增敏现有免疫治疗。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">科研</span>者们在自发性肝癌模型小鼠中，进一步证实了SOX18过表达对HCC<span style="color: black;">出现</span>发展有<span style="color: black;">知道</span>的促进<span style="color: black;">功效</span>，敲除SOX18可<span style="color: black;">明显</span>减少TAMs和Tregs浸润，延缓HCC<span style="color: black;">发展</span>及转移，而针对CXCR4、TGFβR1等<span style="color: black;">重要</span>节点进行<span style="color: black;">干涉</span>，如<span style="color: black;">运用</span>在研小分子<span style="color: black;">控制</span>剂，<span style="color: black;">亦</span>可起到<span style="color: black;">类似</span>的<span style="color: black;">功效</span>，并与PD-L1<span style="color: black;">控制</span>剂协同增效，有望在<span style="color: black;">将来</span><span style="color: black;">构成</span>免疫联合治疗<span style="color: black;">方法</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">原文；Chen J, Feng W, Sun M, et al. TGF-β1 Induced SOX18 Elevation Promotes Hepatocellular Carcinoma Progression and Metastasis through Transcriptionally Upregulating PD-L1 and CXCL12. Gastroenterology, 2024.</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">【18】Cancer Cell：CAR-T细胞与<span style="color: black;">控制</span>性<span style="color: black;">药品</span>的组合或有望治疗高<span style="color: black;">危害</span>的神经母细胞瘤<span style="color: black;">病人</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2024-03-08<span style="color: black;">报告</span>，<span style="color: black;">近期</span>，一篇<span style="color: black;">发布</span>在国际杂志Cancer Cell上题为“ALK inhibitors increase ALK expression and sensitize neuroblastoma cells to ALK.CAR-T cells”的<span style="color: black;">科研</span>报告中，来自哈佛医学院等<span style="color: black;">公司</span>的<span style="color: black;">专家</span>们<span style="color: black;">经过</span><span style="color: black;">科研</span>报告了一种新<span style="color: black;">办法</span>或能<span style="color: black;">促进</span>CAR-T细胞疗法能更好地治疗神经母细胞瘤，<span style="color: black;">她们</span><span style="color: black;">期盼</span>这一<span style="color: black;">办法</span>能尽快在高<span style="color: black;">危害</span>儿童中进行测试。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">科研</span>者<span style="color: black;">暗示</span>，如今复发性的高<span style="color: black;">危害</span>神经母细胞瘤依然是一个非常<span style="color: black;">要紧</span>的临床问题，当前的临床前<span style="color: black;">科研</span>数据让<span style="color: black;">她们</span>非常鼓舞，<span style="color: black;">况且</span><span style="color: black;">她们</span><span style="color: black;">亦</span>非常高兴能为<span style="color: black;">病人</span><span style="color: black;">供给</span>这种疗法。综上，本文<span style="color: black;">科研</span>结果<span style="color: black;">显示</span>，CAR-T细胞<span style="color: black;">做为</span>单一疗法治疗低ALK密度的神经母细胞瘤<span style="color: black;">病人</span>或许是足够的，<span style="color: black;">况且</span>新型组合性疗法还能特异性地<span style="color: black;">加强</span><span style="color: black;">病人</span>的治疗疗效。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">原文；DOI:10.1016/j.ccell.2023.11.004</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">【19】Cell Mol Immunol：<span style="color: black;">专家</span>在肿瘤<span style="color: black;">关联</span>的巨噬细胞中识别出了特殊的酶类<span style="color: black;">检测</span>点</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2024-03-07<span style="color: black;">报告</span>，<span style="color: black;">近期</span>，一篇<span style="color: black;">发布</span>在国际杂志Cellular & Molecular Immunology上题为“Targeting PHGDH reverses the immunosuppressive phenotype of tumor-associated macrophages through α-ketoglutarate and mTORC1 signaling”的<span style="color: black;">科研</span>报告中，来自维<span style="color: black;">亦</span>纳大学等<span style="color: black;">公司</span>的<span style="color: black;">专家</span>们<span style="color: black;">发掘</span>，PHGDH或能在肿瘤<span style="color: black;">关联</span>的巨噬细胞中扮演一种代谢<span style="color: black;">检测</span>点的角色，从而影响肿瘤的生长。靶向<span style="color: black;">功效</span>PHGDH来调节抵御癌症的免疫系统或许是癌症疗法的新起点，其能改善临床免疫疗法的疗效。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">本文<span style="color: black;">科研</span>为<span style="color: black;">专家</span>们深入理解免疫调节和癌症<span style="color: black;">出现</span>之间的相互<span style="color: black;">功效</span><span style="color: black;">供给</span>了基本的见解，并揭示了<span style="color: black;">研发</span>调节肿瘤<span style="color: black;">关联</span>巨噬细胞的策略从而抵御肿瘤的<span style="color: black;">潜能</span>，<span style="color: black;">将来</span>，还<span style="color: black;">必须</span><span style="color: black;">专家</span>们<span style="color: black;">连续</span>更深入地<span style="color: black;">科研</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">原文；doi：10.1038/s41423-024-01134-0</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">【20】Genome Biol：新型筛选<span style="color: black;">工具</span>或能揭示人类癌症、<span style="color: black;">自己</span>免疫性<span style="color: black;">疾患</span>和神经变性等<span style="color: black;">疾患</span>的发病机制</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2024-03-07<span style="color: black;">报告</span>，<span style="color: black;">近期</span>，一篇<span style="color: black;">发布</span>在国际杂志Genome Biology上题为“scSNV-seq: high-throughput phenotyping of single nucleotide variants by coupled single-cell genotyping and transcriptomics”的<span style="color: black;">科研</span>报告中，来自欧洲分子生物学实验室等<span style="color: black;">公司</span>的<span style="color: black;">专家</span>们<span style="color: black;">经过</span><span style="color: black;">科研</span><span style="color: black;">研发</span>了一种新型筛选<span style="color: black;">工具</span>，其活能揭示遗传改变<span style="color: black;">怎样</span>影响基因活性，并可能<span style="color: black;">引起</span>诸如癌症、<span style="color: black;">自己</span>免疫性<span style="color: black;">疾患</span>、神经变性和心血管<span style="color: black;">疾患</span>等<span style="color: black;">疾患</span>的<span style="color: black;">出现</span>；这种新型<span style="color: black;">工具</span>还能<span style="color: black;">帮忙</span><span style="color: black;">科研</span>人员在一项实验中对遗传学<span style="color: black;">科研</span>所识别出的数千个DNA突变进行调查，并<span style="color: black;">指点</span>先进诊断技术和疗法的<span style="color: black;">研发</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">Sarah Cooper博士说道，在一个遗传突变<span style="color: black;">发掘</span>速度超过<span style="color: black;">咱们</span>解释其影响效应能力的时代，scSNV-seq技术就能填补<span style="color: black;">专家</span>们<span style="color: black;">科研</span>诸如T细胞和神经元等挑战性细胞的<span style="color: black;">重点</span>空白，如今<span style="color: black;">咱们</span><span style="color: black;">已然</span>能利用该技术来解释阿尔兹海默病和帕金森<span style="color: black;">疾患</span><span style="color: black;">危害</span>突变对人类大脑细胞的影响。最后<span style="color: black;">科研</span>者<span style="color: black;">暗示</span>，这种新型技术活能直接将突变的影响与细胞的<span style="color: black;">行径</span>改变联系起来，并揭示了此前技术<span style="color: black;">没</span>法单独<span style="color: black;">供给</span>的下游影响效应；<span style="color: black;">同期</span>该技术还能<span style="color: black;">帮忙</span><span style="color: black;">科研</span>人员加速识别致病基因突变，从而就能对<span style="color: black;">疾患</span>进行更好地诊断，并加深对<span style="color: black;">疾患</span>发病机制的理解，<span style="color: black;">亦</span>为后期<span style="color: black;">专家</span>们<span style="color: black;">研发</span>更具靶向性和有效的疗法铺平道路。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">原文；doi：10.1186/s13059-024-03169-y</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">【21】Nat Med | 中山大学徐瑞华/王峰<span style="color: black;">发掘</span>治疗不可切除化疗难治性局部晚期或转移性微卫星稳定/<span style="color: black;">有效</span>错配修复结直肠癌的新策略</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2024-03-07<span style="color: black;">报告</span>，中山大学徐瑞华及王峰<span style="color: black;">一起</span>通讯在Nature Medicine （IF 83）在线<span style="color: black;">发布</span>题为“Combined anti-PD-1, HDAC inhibitor and anti-VEGF for MSS/pMMR colorectal cancer: a randomized phase 2 trial”的<span style="color: black;">科研</span>论文，该<span style="color: black;">科研</span>进行了程序性细胞死亡蛋白-1 (PD-1)单克隆抗体sintilimab与组蛋白去乙酰化酶<span style="color: black;">控制</span>剂(HDACi) chidamide联合或不联合抗血管内皮生长因子(VEGF)单克隆抗体bevacizumab治疗不可切除化疗难治性局部晚期或转移性微卫星稳定/<span style="color: black;">有效</span>错配修复(MSS/pMMR)结直肠癌<span style="color: black;">病人</span>的潜在疗效的一项随机2期<span style="color: black;">实验</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">总之，该<span style="color: black;">科研</span>为在MSS/pMMR不可切除的局部晚期或转移性结直肠癌<span style="color: black;">病人</span>中联合<span style="color: black;">运用</span>齐达胺和辛替单抗或不<span style="color: black;">运用</span>贝伐单抗<span style="color: black;">供给</span>了有<span style="color: black;">期盼</span>的初步结果。三联疗法的治疗效果优于单联疗法，这种疗效的潜在机制与CD8+ T细胞的浸润和活化<span style="color: black;">相关</span>。总的<span style="color: black;">来讲</span>，三联疗法可能是MSS/pMMR晚期结直肠癌的有效治疗<span style="color: black;">选取</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">【22】J Hepatol | 复旦大学李辉/郭磊/叶青海/樊嘉合作等<span style="color: black;">发掘</span>CRKL调控抗PD-1耐药性的潜在机理</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2024-03-07<span style="color: black;">报告</span>，复旦大学李辉、郭磊、叶青海、樊嘉及中国台湾中国医科大学洪明奇（Mien-Chie Hung）等合作在Journal of Hepatology 在线<span style="color: black;">发布</span>题为“CRKL dictates anti-PD-1 resistance by mediating tumor-associated neutrophil infiltration in hepatoce”的<span style="color: black;">科研</span>论文，该<span style="color: black;">科研</span><span style="color: black;">发掘</span>CRKL<span style="color: black;">经过</span>介导肝癌中肿瘤<span style="color: black;">关联</span>的中性粒细胞浸润来调控抗PD-1的耐药性。CRKL是一种候选抗PD-1耐药基因。CRKL过表达<span style="color: black;">经过</span>动员肿瘤<span style="color: black;">关联</span>中性粒细胞(TANs)阻断CD8+ T细胞的浸润和功能而使抗PD-1治疗效果<span style="color: black;">没</span>效。PD-L1+ TANs被<span style="color: black;">发掘</span>是TANs的一个<span style="color: black;">要紧</span>子集，受CRKL表达调节，并表现出免疫<span style="color: black;">控制</span>表型。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">在机制上，CRKL<span style="color: black;">经过</span>竞争性地降低Axin1结合<span style="color: black;">控制</span>APC介导的β连环蛋白蛋白酶体降解，从而促进VEGFα和CXCL1的表达。<span style="color: black;">运用</span>人类HCC样本，验证了CRKL/β-catenin/VEGFα与CXCL1的正<span style="color: black;">关联</span>。利用CRISPR-Cas9基因编辑(CRKL敲除)靶向CRKL或其下游调节因子，在原位小鼠模型和<span style="color: black;">病人</span>源性器官型肿瘤球体(PDOTS)模型中有效恢复抗PD-1治疗的疗效。CRKL/β-catenin/VEGFα和CXCL1轴的激活是成功抗PD-1治疗的<span style="color: black;">重要</span><span style="color: black;">阻碍</span>。<span style="color: black;">因此呢</span>，CRKL<span style="color: black;">控制</span>剂联合抗PD-1可能用于治疗HCC。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">该<span style="color: black;">科研</span><span style="color: black;">发掘</span>CRKL在抗PD-1耐药的HCC组织中表达上调，CRKL过表达<span style="color: black;">经过</span>募集TANs和重塑肿瘤免疫微环境(TIME)促进抗PD-1耐药，提示CRKL是克服抗PD-1耐药的潜在靶点。这些<span style="color: black;">发掘</span>支持以贝伐单抗为<span style="color: black;">基本</span>的ICIs联合治疗策略，CRKL<span style="color: black;">控制</span>剂联合抗PD-1治疗可能被<span style="color: black;">研发</span>用于HCC的治疗。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">【23】Nat Commun：新<span style="color: black;">科研</span>揭示KSHV病毒劫持人类蛋白诱发癌症机制</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2024-03-06<span style="color: black;">报告</span>，在一项新的<span style="color: black;">科研</span>中，来自美国克利夫兰诊所的<span style="color: black;">科研</span>人员<span style="color: black;">发掘</span>了卡波西肉瘤<span style="color: black;">关联</span>疱疹病毒（Kaposis sarcoma-associated herpesvirus, KSHV）——又<span style="color: black;">叫作</span>为人类疱疹病毒8型（human herpesvirus 8, HHV8），诱发癌症的一个<span style="color: black;">重要</span>机制。这一<span style="color: black;">发掘</span>为<span style="color: black;">包含</span>卡波西肉瘤、原发性渗出性淋巴瘤和HHV8 <span style="color: black;">关联</span>多中心卡斯特曼病在内的KSHV <span style="color: black;">关联</span>癌症<span style="color: black;">供给</span>了有效的新治疗<span style="color: black;">方法</span>。<span style="color: black;">关联</span><span style="color: black;">科研</span>结果于2024年2月16日<span style="color: black;">发布</span>在Nature Communications期刊上，论文标题为“Hijacking of nucleotide biosynthesis and deamidation-mediated glycolysis by an oncogenic herpesvirus”。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">论文通讯作者、克利夫兰诊所佛罗里达<span style="color: black;">科研</span>与创新中心的Jun Zhao博士说，“<span style="color: black;">咱们</span>的<span style="color: black;">科研</span>结果<span style="color: black;">拥有</span>重大<span style="color: black;">道理</span>：<span style="color: black;">全世界</span>10%至20%的癌症<span style="color: black;">是由于</span>病毒<span style="color: black;">导致</span>的，随着新<span style="color: black;">发掘</span>的<span style="color: black;">显现</span>，这一数字还在<span style="color: black;">持续</span><span style="color: black;">增多</span>。用标准的癌症疗法治疗病毒诱发的癌症<span style="color: black;">能够</span><span style="color: black;">帮忙</span>缩小<span style="color: black;">已然</span>存在的肿瘤，但并<span style="color: black;">不可</span><span style="color: black;">处理</span>内在的病毒感染问题。<span style="color: black;">认识</span>病原体<span style="color: black;">怎样</span>将健康细胞转化为癌细胞，<span style="color: black;">能够</span><span style="color: black;">发掘</span>可利用的漏洞，使<span style="color: black;">咱们</span>能够制造和重新利用现有<span style="color: black;">药品</span>，有效治疗与病毒<span style="color: black;">关联</span>的恶性肿瘤。”</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">Zhao博士和他的团队正在<span style="color: black;">奋斗</span>更好地<span style="color: black;">认识</span> KSHV、CDK6/CAD 通路和癌症形成之间的联系。<span style="color: black;">她们</span>计划利用所<span style="color: black;">得到</span>的知识，实施和改进<span style="color: black;">她们</span>的实验性<span style="color: black;">药品</span>组合，以便进行临床<span style="color: black;">实验</span>。 Zhao博士说，“病毒和癌症都可能劫持细胞代谢，<span style="color: black;">引起</span>发病。<span style="color: black;">经过</span><span style="color: black;">科研</span>这些代谢重构机制，<span style="color: black;">咱们</span><span style="color: black;">期盼</span>找到致癌病毒和非病毒性癌症的致命弱点。我很期待看到这类<span style="color: black;">科研</span>工作的<span style="color: black;">将来</span><span style="color: black;">发展</span>。”</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">原文；doi:10.1038/s41467-024-45852-5.</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">【24】Nature：<span style="color: black;">专家</span>揭示人类肺腺癌<span style="color: black;">出现</span>最<span style="color: black;">初期</span>的细胞起源机制</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2024-03-06<span style="color: black;">报告</span>，<span style="color: black;">近期</span>，一篇<span style="color: black;">发布</span>在国际杂志Nature上题为“An atlas of epithelial cell states and plasticity in lung adenocarcinoma”的<span style="color: black;">科研</span>报告中，来自德克萨斯大学MD安德森癌症中心等<span style="color: black;">公司</span>的<span style="color: black;">专家</span>们<span style="color: black;">经过</span><span style="color: black;">科研</span>构建出了肺部细胞的新型图谱，揭示了肺腺癌<span style="color: black;">出现</span>的新型细胞途径和前体，<span style="color: black;">关联</span><span style="color: black;">科研</span><span style="color: black;">发掘</span>或有望<span style="color: black;">帮忙</span><span style="color: black;">研发</span>新型策略在<span style="color: black;">初期</span>进行检测或阻断<span style="color: black;">疾患</span>的<span style="color: black;">发展</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">科研</span>者Kadara说道，<span style="color: black;">咱们</span>的<span style="color: black;">科研</span><span style="color: black;">供给</span>了<span style="color: black;">知道</span>的证据<span style="color: black;">显示</span>，肿瘤细胞的确产生于这些中间状态的细胞，这就为后期新的<span style="color: black;">科研</span>打开了一扇<span style="color: black;">前门</span>。这些<span style="color: black;">科研</span><span style="color: black;">发掘</span><span style="color: black;">亦</span>让<span style="color: black;">科研</span>人员非常激动，<span style="color: black;">由于</span>其<span style="color: black;">显示</span>，KRAS<span style="color: black;">控制</span>剂活能在临床疗法中产生<span style="color: black;">必定</span>的治疗益处，<span style="color: black;">乃至</span>还能有效阻断肺腺癌<span style="color: black;">出现</span>的原始<span style="color: black;">周期</span>。<span style="color: black;">日前</span><span style="color: black;">科研</span>人员正在联合<span style="color: black;">科研</span>探索<span style="color: black;">是不是</span>能利用组合性疗法来靶向<span style="color: black;">功效</span>这些细胞，并调查这些细胞向<span style="color: black;">包含</span>炎症在内的肺腺癌转化的分子机制。这些<span style="color: black;">初期</span>转化可能会受到<span style="color: black;">周边</span>肿瘤微环境的<span style="color: black;">明显</span>影响。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">经过</span>进行深入的空间分析全面理解这些细胞和免疫微环境之间的动态相互<span style="color: black;">功效</span>，或许就能为进行<span style="color: black;">疾患</span>的<span style="color: black;">初期</span><span style="color: black;">发掘</span>并<span style="color: black;">研发</span>出新型拦截策略<span style="color: black;">供给</span><span style="color: black;">重要</span>的线索和思路。综上，本文<span style="color: black;">科研</span>结果<span style="color: black;">亦</span>为阐明肺腺癌<span style="color: black;">出现</span>的上皮细胞状态<span style="color: black;">供给</span>了新的<span style="color: black;">科研</span>认识，这些状态或许有望<span style="color: black;">帮忙</span>寻找<span style="color: black;">研发</span>新型预防性或<span style="color: black;">干涉</span>性策略的潜在靶点。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">原文；doi：10.1038/s41586-024-07113-9</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">【25】Nature Genetics | 癌症基因组学的新突破：探索<span style="color: black;">繁杂</span>基因型与表型<span style="color: black;">相关</span>的组合遗传策略</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2024-03-06<span style="color: black;">报告</span>，Nature Genetics的<span style="color: black;">报告</span>“A combinatorial genetic strategy for exploring complex genotype–phenotype associations in cancer”提出了一种组合遗传策略，旨在<span style="color: black;">经过</span>在器官培养中应用多种遗传操作，快速生成<span style="color: black;">拥有</span>临床<span style="color: black;">关联</span>性的膀胱和前列腺癌模型。这种策略的创新之处在于，它<span style="color: black;">准许</span><span style="color: black;">咱们</span>在单一模型中<span style="color: black;">同期</span>观察多个基因的相互<span style="color: black;">功效</span>和影响，从而深入揭示癌症发展过程中的<span style="color: black;">繁杂</span>基因型与表型<span style="color: black;">相关</span>。<span style="color: black;">另外</span>，采用单细胞和空间解析的NGS技术，<span style="color: black;">能够</span>对肿瘤的克隆结构进行精确解析，进一步挖掘多基因驱动癌症表型的机制。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">该<span style="color: black;">科研</span>不仅<span style="color: black;">增多</span>了对癌症多样性的理解，<span style="color: black;">况且</span><span style="color: black;">供给</span>了一种强大的<span style="color: black;">工具</span>，用于<span style="color: black;">科研</span>在<span style="color: black;">区别</span>基因背景下癌症的<span style="color: black;">行径</span>和治疗反应，这对癌症的<span style="color: black;">精细</span>治疗有<span style="color: black;">要紧</span><span style="color: black;">道理</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">原文；A combinatorial genetic strategy for exploring complex genotype–phenotype associations in cancer</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">【26】上海交大<span style="color: black;">科研</span><span style="color: black;">发掘</span>，<span style="color: black;">每日</span>吃5-6克洋葱，肝癌<span style="color: black;">危害</span>或降低33%</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2024-03-06<span style="color: black;">报告</span>，<span style="color: black;">近期</span>，上海交通大学医学院<span style="color: black;">附庸</span>仁济医院项永兵等人在《欧洲流行病学杂志》上<span style="color: black;">发布</span>了一篇题为" A diet-wide association study for liver cancer risk：findings from a prospective cohort study in Chinese men "的<span style="color: black;">科研</span>论文。 <span style="color: black;">科研</span><span style="color: black;">表示</span>，较高的洋葱和锰摄入量与肝癌<span style="color: black;">危害</span>降低<span style="color: black;">关联</span>，<span style="color: black;">每日</span>吃5-6克洋葱，肝癌<span style="color: black;">危害</span>降低33%。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">在这项<span style="color: black;">科研</span>中，<span style="color: black;">科研</span>人员分析了上海男性健康<span style="color: black;">科研</span>（SMHS）中59844名男性的数据，<span style="color: black;">经过</span><span style="color: black;">膳食</span>问卷收集了参与者的<span style="color: black;">膳食</span>信息，总共<span style="color: black;">包含</span>142种<span style="color: black;">膳食</span><span style="color: black;">原因</span>，其中104种<span style="color: black;">食品</span>和38种营养素，<span style="color: black;">评定</span>了一系列<span style="color: black;">膳食</span><span style="color: black;">原因</span>与肝癌<span style="color: black;">危害</span>之间的<span style="color: black;">相关</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">科研</span>人员<span style="color: black;">暗示</span>，这是亚洲<span style="color: black;">第1</span>项系统<span style="color: black;">评定</span>一系列<span style="color: black;">膳食</span><span style="color: black;">原因</span>与肝癌<span style="color: black;">危害</span>之间关系的队列<span style="color: black;">科研</span>，并进行多重比较和重复分析。<span style="color: black;">将来</span>，<span style="color: black;">必须</span><span style="color: black;">更加多</span>的流行病学<span style="color: black;">科研</span>来进一步验证。 综上，结果<span style="color: black;">显示</span>，较高的视黄醇摄入量与肝癌<span style="color: black;">危害</span><span style="color: black;">增多</span><span style="color: black;">关联</span>，而较高的洋葱和锰摄入量与肝癌<span style="color: black;">危害</span>降低<span style="color: black;">关联</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">【27】Med：感觉神经或会驱动头颈癌的生长</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2024-03-06 <span style="color: black;">报告</span>，<span style="color: black;">近期</span>，一篇<span style="color: black;">发布</span>在国际杂志Med上题为“Sensory nerve release of CGRP increases tumor growth in HNSCC by suppressing TILs”的<span style="color: black;">科研</span>报告中，来自科罗拉多大学等<span style="color: black;">公司</span>的<span style="color: black;">专家</span>们<span style="color: black;">经过</span><span style="color: black;">科研</span>分析了神经和肿瘤微环境之间的相互<span style="color: black;">功效</span>，结果<span style="color: black;">发掘</span>，诸如肉毒杆菌（保妥适，botox）等常用<span style="color: black;">药品</span>或会阻断或减缓某些头颈癌的<span style="color: black;">发展</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">文案</span>中，<span style="color: black;">科研</span>人员分析了肿瘤微环境中的神经<span style="color: black;">怎样</span>影响宿主机体的免疫系统和癌症的生长；<span style="color: black;">科研</span>者Laurel Darragh博士说道，<span style="color: black;">咱们</span>早就<span style="color: black;">晓得</span>，肿瘤微环境中神经相互<span style="color: black;">功效</span>的强度或与头颈鳞状细胞癌<span style="color: black;">病人</span>的预后较差<span style="color: black;">关联</span>，这或许就<span style="color: black;">促进</span><span style="color: black;">科研</span>人员调查这些神经相互<span style="color: black;">功效</span><span style="color: black;">怎样</span>影响机体的适应性免疫系统和肿瘤生长。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">本文<span style="color: black;">科研</span>结果<span style="color: black;">显示</span>，感觉神经活能<span style="color: black;">经过</span>直接<span style="color: black;">功效</span>于机体适应性免疫系统从而减少肿瘤微环境中的Th1 CD4 T细胞和激活CD8 T细胞，从而在加速肿瘤生长中扮演<span style="color: black;">重要</span>角色，<span style="color: black;">关联</span><span style="color: black;">科研</span>数据支持<span style="color: black;">专家</span>们进一<span style="color: black;">步骤</span>查感觉神经在头颈鳞状细胞癌的肿瘤微环境中所扮演的<span style="color: black;">重要</span>角色，并指出，阻断感觉神经的功能或特异性地<span style="color: black;">控制</span>肿瘤微环境中的CGRP的释放或活性从而改善<span style="color: black;">病人</span>的预后或会产生<span style="color: black;">必定</span>的治疗效应。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">原文：DOI:10.1016/j.medj.2024.02.002</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">【28】Nature子刊：华人学者揭开病毒致癌机制，并提出潜在治疗<span style="color: black;">办法</span></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2024-03-06<span style="color: black;">报告</span>，<span style="color: black;">近期</span>，美国克利夫兰医学中心 Jun Zhao 团队在 Nature Communications 期刊<span style="color: black;">发布</span>了题为：Hijacking of nucleotide biosynthesis and deamidation-mediated glycolysis by an oncogenic herpesvirus 的<span style="color: black;">科研</span>论文。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">该<span style="color: black;">科研</span><span style="color: black;">发掘</span>，KSHV<span style="color: black;">经过</span><span style="color: black;">操作</span>两种人类酶——细胞分裂蛋白激酶6（CDK6）及氨甲酰磷酸合成酶2，天冬氨酸氨甲酰转移酶和二氢乳清酸酶（CAD，嘧啶从头合成的<span style="color: black;">重要</span>酶），重塑人类细胞产生新核苷酸和处理葡萄糖的方式。感染细胞生长和KSHV<span style="color: black;">连续</span>存在的方式的变化使细胞形成肿瘤的<span style="color: black;">危害</span>大大<span style="color: black;">加强</span>，并在<span style="color: black;">引起</span>癌症方面发挥了至关<span style="color: black;">要紧</span>的<span style="color: black;">功效</span>。而<span style="color: black;">运用</span>FDA<span style="color: black;">准许</span>的乳腺癌<span style="color: black;">药品</span>CDK6<span style="color: black;">控制</span>剂来<span style="color: black;">控制</span>该过程，可减少KSHV复制，阻止原发性渗出性淋巴瘤（PEL）<span style="color: black;">发展</span>，缩小并清除已有肿瘤。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">该<span style="color: black;">科研</span>揭示了支持KSHV<span style="color: black;">关联</span>肿瘤<span style="color: black;">出现</span>的病毒代谢重编程机制，为治疗KSHV<span style="color: black;">关联</span>恶性肿瘤和其他<span style="color: black;">疾患</span><span style="color: black;">供给</span>了新策略和新靶点。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">论文通讯作者、克利夫兰医学中心佛罗里达<span style="color: black;">科研</span>与创新中心的 Jun Zhao 博士<span style="color: black;">暗示</span>，这些<span style="color: black;">发掘</span><span style="color: black;">拥有</span>重大<span style="color: black;">道理</span>：病毒<span style="color: black;">引起</span><span style="color: black;">全世界</span>10%-20%的癌症，<span style="color: black;">实质</span>上，这个数字还在<span style="color: black;">持续</span><span style="color: black;">增多</span>。<span style="color: black;">运用</span>标准的癌症治疗<span style="color: black;">办法</span>治疗病毒诱发的癌症<span style="color: black;">能够</span><span style="color: black;">帮忙</span>缩小<span style="color: black;">已然</span>存在的肿瘤，但这并<span style="color: black;">不可</span><span style="color: black;">处理</span>病毒的<span style="color: black;">基本</span>问题，<span style="color: black;">认识</span>病原体<span style="color: black;">怎样</span>将健康细胞转化为癌细胞，揭示了可利用的漏洞，使<span style="color: black;">咱们</span>能够<span style="color: black;">研发</span>新型<span style="color: black;">药品</span>、重新利用现有<span style="color: black;">药品</span>，以有效治疗病毒<span style="color: black;">关联</span>的恶性肿瘤。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">科研</span>团队<span style="color: black;">暗示</span>，病毒和癌症都<span style="color: black;">能够</span>劫持细胞代谢，<span style="color: black;">经过</span><span style="color: black;">科研</span>这些代谢重编程机制，<span style="color: black;">目的</span>是找到致癌病毒和非病毒性癌症的致命弱点，<span style="color: black;">从而</span>改进当前的实验<span style="color: black;">药品</span>组合，以用于临床<span style="color: black;">实验</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">【29】Cancer Cell：<span style="color: black;">专家</span>有望利用生物标志物来预测免疫疗法的成功</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2024-03-05<span style="color: black;">报告</span>，<span style="color: black;">近期</span>，一篇<span style="color: black;">发布</span>在国际杂志Cancer Cell上题为“Interferon-stimulated neutrophils as a predictor of immunotherapy response”的<span style="color: black;">科研</span>报告中，来自以色列理工学院等<span style="color: black;">公司</span>的<span style="color: black;">专家</span>们<span style="color: black;">经过</span><span style="color: black;">科研</span><span style="color: black;">发掘</span>了一种能预测免疫疗法成功的血细胞亚群，这些<span style="color: black;">科研</span><span style="color: black;">发掘</span>或有望<span style="color: black;">帮忙</span>简化将免疫疗法与特定<span style="color: black;">病人</span>相互匹配的过程，<span style="color: black;">由于</span>提前确定<span style="color: black;">那些</span>病人会对某种疗法产生反应是非常<span style="color: black;">要紧</span>的。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">科研</span>人员推测，检测<span style="color: black;">病人</span>血液中的Ly6Ehi中性粒细胞的水平或能<span style="color: black;">做为</span>一种有效的生物标志物来预测<span style="color: black;">病人</span>对免疫疗法所产生的反应，随后<span style="color: black;">科研</span>人员在肺癌和黑色素瘤<span style="color: black;">病人</span>机体中测试了这种基于临床前<span style="color: black;">科研</span>的<span style="color: black;">发掘</span>；这些<span style="color: black;">发掘</span>与对1237名接受基于抗体的免疫疗法的癌症<span style="color: black;">病人</span>的现有数据的分析结果一致，<span style="color: black;">因此呢</span>，<span style="color: black;">她们</span>阐明了中性粒细胞或能以高度的准确性来预测人类对免疫疗法的反应。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">科研</span>者Yuval Shaked教授等人所<span style="color: black;">研发</span>的技术<span style="color: black;">日前</span><span style="color: black;">已然</span>申请了专利，且正在与OncoHost<span style="color: black;">机构</span>进行技术转让从而促进其继续<span style="color: black;">研发</span>，<span style="color: black;">科研</span>者指出，这项技术<span style="color: black;">能够</span>与<span style="color: black;">没</span>处不在的流式细胞仪<span style="color: black;">一块</span><span style="color: black;">运用</span>，而流式细胞仪几乎能在每家医院中找到且得到了监管<span style="color: black;">公司</span>的<span style="color: black;">准许</span>。综上，本文<span style="color: black;">科研</span>识别出了一种功能活跃的生物标志物，其或能用于小鼠和人类<span style="color: black;">科研</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">》》》</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">复制链接，加入实验技术交流群，找到志同道合的人：</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">https://wizard.kuaizhan.com/21/76/p1004595033e462f</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><a style="color: black;"><span style="color: black;">返回<span style="color: black;">外链论坛：http://www.fok120.com/</span>，查看<span style="color: black;">更加多</span></span></a></p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">责任编辑：网友投稿</span></p>
外链论坛的成功举办，是与各位领导、同仁们的关怀和支持分不开的。在此，我谨代表公司向关心和支持论坛的各界人士表示最衷心的感谢！ 期待更新、坐等、迫不及待等。 期待更新、坐等、迫不及待等。 谢谢、感谢、感恩、辛苦了、有你真好等。 seo常来的论坛，希望我的网站快点收录。
页:
[1]