癌症肿瘤治疗靶点/生物标志物最新发展（2022年11月）
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">【1】Sci Adv：识别出一种促进乳腺癌<span style="color: black;">出现</span>的特殊调节子</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2022-11-16<span style="color: black;">报告</span>，<span style="color: black;">近期</span>，一篇<span style="color: black;">发布</span>在国际杂志Science Advances上题为“ZMYND8 is a master regulator of 27-hydroxycholesterol that promotes tumorigenicity of breast cancer stem cells”的<span style="color: black;">科研</span>报告中，来自德克萨斯大学西南医学中心等<span style="color: black;">公司</span>的<span style="color: black;">专家</span>们<span style="color: black;">经过</span><span style="color: black;">科研</span>在乳腺癌中识别出了一种致病性的信号通路，其或有望为<span style="color: black;">研发</span>治疗这种<span style="color: black;">平常</span>乳腺癌的新型疗法<span style="color: black;">供给</span>潜在的新型靶点。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">本文<span style="color: black;">科研</span>基于此前<span style="color: black;">科研</span>结果，此前<span style="color: black;">科研</span>中，<span style="color: black;">科研</span>人员识别出了一种名为ZMYND8的基因或能<span style="color: black;">做为</span>乳腺肿瘤生长的调节子，这项<span style="color: black;">科研</span>中，<span style="color: black;">科研</span>人员进一步分析了乳腺癌<span style="color: black;">出现</span>过程中ZMYND8的<span style="color: black;">重要</span>角色以及27-羟基胆固醇的水平，<span style="color: black;">科研</span>者Weibo Luo说道，本文<span style="color: black;">科研</span>确定了诱发乳腺癌的一种<span style="color: black;">原由</span>，乳腺癌是<span style="color: black;">全世界</span>女性因癌症<span style="color: black;">关联</span>死亡的<span style="color: black;">重点</span><span style="color: black;">原由</span>，这项新的<span style="color: black;">科研</span><span style="color: black;">发掘</span><span style="color: black;">表率</span>着<span style="color: black;">科研</span>人员向<span style="color: black;">研发</span>新型有效疗法并尽可能早地确定<span style="color: black;">病人</span>的乳腺癌<span style="color: black;">危害</span>又迈出了<span style="color: black;">要紧</span>的一步。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">原文：DOI: 10.1126/sciadv.abn5295</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">【2】Cancer Discov：细胞竞争或许能<span style="color: black;">帮忙</span>解释癌症复发的分子机制</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2022-11-15<span style="color: black;">报告</span>，<span style="color: black;">近期</span>，一篇<span style="color: black;">发布</span>在国际杂志Cancer Discovery上题为“Cell Competition Shapes Metastatic Latency and Relapse”的<span style="color: black;">科研</span>报告中，来自西南医学中心等<span style="color: black;">公司</span>的<span style="color: black;">专家</span>们<span style="color: black;">经过</span><span style="color: black;">科研</span><span style="color: black;">发掘</span>，细胞竞争或许是癌症<span style="color: black;">病人</span>被宣布机体<span style="color: black;">没</span>癌后数月或数年后癌症<span style="color: black;">出现</span>复发的<span style="color: black;">原由</span>；<span style="color: black;">关联</span><span style="color: black;">科研</span>结果或有望<span style="color: black;">帮忙</span><span style="color: black;">研发</span>更好的<span style="color: black;">办法</span>来治疗<span style="color: black;">乃至</span>预防癌症转移，或<span style="color: black;">控制</span>肿瘤扩散到机体的<span style="color: black;">区别</span>部位。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;"><span style="color: black;">科研</span>者Srinivas Mallad说道，本文<span style="color: black;">科研</span>结果<span style="color: black;">显示</span>，原发性肿瘤内部的细胞竞争会<span style="color: black;">引起</span>适应度不太好的细胞被转移到机体循环中，但并不是所有“<span style="color: black;">没</span>家可归”的细胞都会<span style="color: black;">出现</span>死亡，其中<span style="color: black;">有些</span><span style="color: black;">拥有</span>转移潜能的细胞会在循环中存活下来，并在远端器官中<span style="color: black;">保持</span>存在且开启癌症的转移。转移在大<span style="color: black;">都数</span>癌症中非常<span style="color: black;">平常</span>，在肾透明细胞癌（ccRCC，clear cell renal carcinoma，一种最<span style="color: black;">平常</span>的肾脏癌症形式）中，新的转移病灶<span style="color: black;">一般</span>会在原发性肿瘤切除后很久才会<span style="color: black;">显现</span>，这一过程被<span style="color: black;">叫作</span>之为异时性转移（metachronous metastasis），如今<span style="color: black;">科研</span>人员<span style="color: black;">已然</span><span style="color: black;">晓得</span>，这种转移方式会在几个月或几年后<span style="color: black;">出现</span>，而许多病人和其<span style="color: black;">大夫</span>都认为其机体<span style="color: black;">已然</span><span style="color: black;">处在</span><span style="color: black;">没</span>癌状态，但其是<span style="color: black;">怎样</span><span style="color: black;">出现</span>的，<span style="color: black;">科研</span>人员并不清楚。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">本文<span style="color: black;">科研</span>结果<span style="color: black;">显示</span>，细胞竞争的一个意外性后果或许<span style="color: black;">便是</span>被<span style="color: black;">拥有</span>潜在转移性潜能的细胞所替换，从而塑造癌症的转移潜能和复发特性。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">原文：DOI:10.1158/2159-8290.CD-22-0236</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">【3】晚期肺癌一线免疫治疗！美国FDA<span style="color: black;">准许</span>抗PD-L1疗法Libtayo+化疗：<span style="color: black;">明显</span>延长总<span style="color: black;">存活</span>期!</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2022年11月09日<span style="color: black;">报告</span>，再生元（Regeneron）<span style="color: black;">近期</span><span style="color: black;">颁布</span>，美国食品和<span style="color: black;">药品</span>管理局（FDA）已<span style="color: black;">准许</span>抗PD-1疗法Libtayo（cemiplimab）：联合含铂化疗，一线治疗<span style="color: black;">没</span>EGFR、ALK或ROS1畸变的晚期非小细胞肺癌（NSCLC）成人<span style="color: black;">病人</span>。<span style="color: black;">详细</span>为：有转移性或局部晚期肿瘤、且不适合手术切除或进行根治性放化疗（definitive chemoradiation）的<span style="color: black;">病人</span>，<span style="color: black;">没</span>论肿瘤PD-L1表达水平或组织学<span style="color: black;">怎样</span>。</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">【4】Cancer Res：一种特殊的干细胞蛋白或会促进髓母细胞瘤患儿<span style="color: black;">疾患</span>的复发</p>
<p style="font-size: 16px; color: black; line-height: 40px; text-align: left; margin-bottom: 15px;">2022-11-14<span style="color: black;">报告</span>，<span style="color: black;">近期</span>，一篇<span style="color: black;">发布</span>在国际杂志Cancer Research上题为“Dormant SOX9-positive cells facilitate MYC-driven recurrence of medulloblastoma”的<span style="color: black;">科研</span>报告中，来自乌普萨拉大学等<span style="color: black;">公司</span>的<span style="color: black;">专家</span>们<span style="color: black;">经过</span><span style="color: black;">科研</span><span style="color: black;">发掘</span>，一种特殊的干细胞蛋</p>
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